Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Regional zircon U-Pb geochronology for the Maniitsoq region, southwest Greenland. [PDF]
Sci Data, 2021 Olierook HKH +11 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Zircon U-Pb geochronology and trace element dataset from the Southern Rocky Mountain Volcanic Field, Colorado, USA. [PDF]
Data Brief, 2022 Sliwinski JT +5 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
U-Pb SHRIMP dating of uraniferous opals
, 2005 U-Pb and U-series analyses of four U-rich opal samples using sensitive high-resolution ion microprobe (SHRIMP) demonstrate the potential of this technique for the dating of opals with ages ranging from several tens of thousand years to millions of years.
Alexander Nemchin (23302264) +2 more
core
Large-number detrital zircon U-Pb ages reveal global cooling caused the formation of the Chinese Loess Plateau during Late Miocene. [PDF]
Sci Adv, 2022 Zhang H +10 more
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Pb(Ⅱ)和Cd(Ⅱ)在长根菇菌丝体中的富集及其对SOD、CAT酶活的影响
四川大学学报. 自然科学版, 2011 以长根菇菌丝体为材料,测定其对Pb(Ⅱ)和Cd(Ⅱ)的富集能力,以及不同浓度的Pb(Ⅱ)和Cd(Ⅱ)对茵丝体超氧化物歧化酶(SOD)和过氧化氢酶(CAT)酶活的影响.研究发现:低浓度Pb(Ⅱ)(100mg/L)明显刺激长根菇茵丝体的生长,而高浓度的Pb(Ⅱ)和Cd(Ⅱ)则抑制其生长;Pb(Ⅱ)和Cd(Ⅱ)的浓度越大,菌丝体对其富集能力越强,其最大富集量可分别达1.2132×10～4mg/kg(Pb(Ⅱ))和1.99872×10～3mg/kg(Cd(Ⅱ)).此外,研究还发现,Pb(Ⅱ)和Cd(Ⅱ ...
陈兰, 陈玉霞, 冯军, 徐恒
doaj