Results 181 to 190 of about 166,341 (292)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

New geological model of the Lagoa Real uraniferous albitites from Bahia (Brazil)

Open Geosciences, 2013
Oliveira Chaves Alexandre
doaj   +1 more source

Method development with LA-ICP-MS in U-Pb geochronology using design of experiment. [PDF]

MethodsX
Caner M, Tunç M, Sunal G, Sarıkaya MA.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Geochemistry and detrital zircon U-Pb-Hf isotopic data reveal the provenance and tectonic setting of the Xujiahe Formation. [PDF]

Sci Rep
Xie F, Xiao W, Sami M, Sanislav IV, Han L, Wang Y, Alhejji SS.   +6 more
europepmc   +1 more source

U-Pb ages of detrital zircons in Cretaceous-Paleogene/Neogene kaolins within Eastern Dahomey and Niger Delta Basins (Nigeria) as provenance indicators. [PDF]

Sci Rep, 2021
Oyebanjo O, Ekosse GI, Odiyo J.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

U-Th and U-Pb geochronology of Quaternary carbonates. [PDF]

Natl Sci Rev
Wang J, Niu X, Kang L, Cheng H.
europepmc   +1 more source

U-Pb возраст плагиогранитов Малыко (Полярный Урал)

Известия Коми научного центра УРО РАН, 2012
First data on the age of plagiogranites spread in the zone of metamorphosed gabbronorites of the Malyksky Complex are given. It is located in the eastern part of the Hadatinsky Ophiolite Massif in the Polar Urals. The concordant U-Pb age of five zircon crystals is 451?b14 Ma and fixes the beginning of granite forming of the Schuchinskaya Zone ...
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source