Results 91 to 100 of about 189,480 (262)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

U-Pb age of rare-element pegmatites at Stora Vika, SE Sweden

open access: yes, 1997
Rare-element pegmatites at Stora Vika are emplaced in gneisses and a metamorphosed carbonate layer. Earlier geochronologic investigations gave a U-Pb zircon age of 1854±5 Ma (2ω), which originally was interpreted to be the age of emplacement, and a Rb-Sr
Romer, Rolf L.,
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

(Table 2) U-Pb monazite results of diatexite G8-57.4 from Mt. Blowaway, northern Oates Coast

open access: yes, 2004
No 1-9: Session 1, calibration error of reference monazite: Pb/U 1.03%; Pb/Th 1.27% (n=9).
Fletcher, I R   +7 more
core   +1 more source

Apatite U-Pb Thermochronology: A Review

open access: yes, 2021
The temperature sensitivity of the U-Pb apatite system (350–570 °C) makes it a powerful tool to study thermal histories in the deeper crust. Recent studies have exploited diffusive Pb loss from apatite crystals to generate t-T paths between ~350–570 °C ...
David M. Chew, Richard A. Spikings
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

(Table 4) U-Pb monazite results of metatexite G8-58.1 from Mt. Dalton, northern Oates Land

open access: yes, 2004
No 1-12: Session 1, calibration error of reference monazite: Pb/U 1.03%; Pb/Th 1.27% (n=9).
Fletcher, I R   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An improved U-Pb age dating method for detrital zircon by LA-MC-ICP-MS

open access: yes, 2018
Detrital zircon U-Pb dating is a powerful tool to trace sources for sedimentary basin and to understand of geological history in structurally complex areas.
Ren, Zhong-Yuan   +4 more
core   +1 more source

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