Results 91 to 100 of about 53,014 (266)

A database of detrital zircon geochronology ages of Cambrian to Paleogene deposits in South China

Geoscience Data Journal
Complications of detrital zircons databases provide a means for statistically analysing a variety of significant geological problems. In this work, we tried to collect a database about the South China Phanerozoic detrital zircon geochronology data.
Tianle Xia, Kuizhou Li, Lisha Hu, Zilin Zhao, Yu Huang, Qianli Ma, Liang Qi   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

First U–Pb LA-ICP-MS Radioisotopic Ages of the Devonian–Carboniferous Boundary Black Shales (Domanik Facies) in the Kama–Kinel Trough System, Volga–Ural Petroleum Province, East European Platform

Georesursy
For the first time, zircons from thin volcanic ash layers contained within organic-rich black shales (Domanik facies) at the Devonian–Carboniferous boundary have been dated using the U–Pb LA-ICP-MS method.
V. V. Silantiev, D. K. Nurgaliev, G. M. Sungatullina, D. N. Miftakhutdinova, A. V. Kulikova, N. G. Nourgalieva, Ya. Ya. Saetgaleeva, A. S. Vandin   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

A database of detrital zircon U–Pb ages and Hf isotope of Precambrian strata in South China

Geoscience Data Journal
Detrital zircon U–Pb chronology database of Precambrian deposits provides a context for the interpretation of the origin and evolution of ancient crust.
Chengzhang Luo, Liang Qi, Tianle Xia
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

U-Pb dating of niobium minerals from the pyrochlore group (Ilmeny-Vishnevogorsky carbonatite-miaskite complex, South Urals)

Литосфера, 2020
The article covers the U-Pb dating of minerals belonging to the pyrochlore group from the rare-metal ore deposits of Ilmeny-Vishnevogorsky carbonatite-miaskite complex (South Urals). Individual pyrochlore crystals were dated through a new technique of in-
I. L. Nedosekova, V. A. Koroteev, B. V. Belyatsky, V. V. Sharygin, Е. N. Lepechinа, S. V. Pribavkin   +5 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source