Results 121 to 130 of about 189,480 (262)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

U-Pb zircon geochronology: A report for Novo Resources, January 2018 P482

, 2018
Aim: To determine the age of three samples by U-Pb ...
Sebastien Meffre (14744152), Stepanov, S (15890081)   +1 more
core  

A database of detrital zircon geochronology ages of Cambrian to Paleogene deposits in South China

Geoscience Data Journal
Complications of detrital zircons databases provide a means for statistically analysing a variety of significant geological problems. In this work, we tried to collect a database about the South China Phanerozoic detrital zircon geochronology data.
Tianle Xia, Kuizhou Li, Lisha Hu, Zilin Zhao, Yu Huang, Qianli Ma, Liang Qi   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

U-Pb zircon and baddeleyite geochronology: A report to Novo Resources, May 2018 P541

, 2018
Aim: To determine the age of 12 basalts and 2 breccia using U-Pb ...
Sebastien Meffre (14744152), Stepanov, S (15890081)   +1 more
core  

A low U/Pb souce in the Moon: U-Th-Pb systematics of lunar meteorite Yamato-793169

, 1993
P(論文)U-Th-Pb isotopic data were determined on mineral separates of the diabasic lunar meteorite, Yamato-793169,in order to define its age and characterize its magma source.
Torigoye,Noriko, Tatsumoto,Mitsunobu, Misawa,Kenji   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A new method integrating high-precision U–Pb geochronology with zircon trace element analysis (U–Pb TIMS-TEA)

, 2010
Increased precision in isotope-dilution thermal ionization mass spectrometry (ID-TIMS) U-Pb geochronology has revealed age complexities in zircon populations that require new tools for understanding how the growth of zircon is related to geologic ...
Latkoczy, C., B. Schoene, D. Günther, U. Schaltegger, Schaltegger, Urs, Günther, D., C. Latkoczy, Schoene, B.   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source