Results 131 to 140 of about 668,632 (409)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Correlation Between U/Th and Pb/Os Abundance Ratios and its Application in Nuclear Cosmochronology

The Astrophysical Journal
The abundance ratios of radioactive elements U/Th and stable elements Pb/Os from the r -process are found to have a strong correlation. This correlation is quite robust with respect to astrophysical conditions.
Y. Y. Huang, Q. Q. Cui, X. H. Wu, S. Q. Zhang   +3 more
doaj   +1 more source

First U–Pb LA-ICP-MS Radioisotopic Ages of the Devonian–Carboniferous Boundary Black Shales (Domanik Facies) in the Kama–Kinel Trough System, Volga–Ural Petroleum Province, East European Platform

Georesursy
For the first time, zircons from thin volcanic ash layers contained within organic-rich black shales (Domanik facies) at the Devonian–Carboniferous boundary have been dated using the U–Pb LA-ICP-MS method.
V. V. Silantiev, D. K. Nurgaliev, G. M. Sungatullina, D. N. Miftakhutdinova, A. V. Kulikova, N. G. Nourgalieva, Ya. Ya. Saetgaleeva, A. S. Vandin   +7 more
doaj   +1 more source

U-Pb isotopic characteristics of lunar meteorites Yamato-793274 and Yamato-86032 [PDF]

, 1991
U-Pb data from lunar meteorites Yamato (Y)-86032 and Y-793274 confirm that they are of lunar origin, but also indicate that they are not from the same source region on the Moon and experienced different events while residing as lunar regolith.
Premo,Wayne R., Tatsumoto,Mitsunobu
core   +1 more source

Methodological aspects of U/Pb dating of zircons using multicollector mass spectrometer with inductively coupled plasma NEPTUNE PLUS with NWR 213 attachment for laser ablation [PDF]

, 2016
Представлена методика анализа изотопного состава Pb и U в цирконах и процедура обработки данных, реализованные на масс-спектрометре с индуктивно-связанной плазмой Neptune Plus (фирма Thermo Scientific), оборудованном одним центральным неподвижным ...
Pupyshev, A. A., Shchapova, J. V., Votyakov, S. L., Zaitceva, M. V., Вотяков, С. Л., Зайцева, М. В., Пупышев, А. А., Щапова, Ю. В.   +7 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Turning Trash Into Treasure: Extracting Meaning From Discordant Data via a Dedicated Application

Geochemistry, Geophysics, Geosystems
Zircon U–Pb geochronology is a vital tool for dating geological events, but interpreting discordant zircon ages—often the result of Pb loss due to fluid‐rock interactions—remains challenging.
Lucy M. Mathieson, C. L. Kirkland, M. L. Daggitt   +2 more
doaj   +1 more source

Simultaneous determination of zircon U-Pb age and titanium concentration using LA-ICP-MS: Analysis data and crystallization temperature. [PDF]

Data Brief, 2020
Yuguchi T, Ishibashi K, Sakata S, Yokoyama T, Itoh D, Ogita Y, Yagi K, Ohno T.   +7 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source