Results 101 to 110 of about 69,082 (309)

Apatite Triple Dating (Lu–Hf, U–Pb, FT) Constrains Deformation and Cooling in the Coompana and Madura Provinces, Western Australia [PDF]

Lithosphere
Combined apatite Lu–Hf, U–Pb, and fission track (AFT) triple dating affords the opportunity to investigate the ~60 and 730°C thermal history of a study area.
Alejandra Bedoya, Stijn Glorie, Martin Hand, Christopher L. Kirkland, David E. Kelsey, Angus Nixon, Geoff Fraser   +6 more
doaj   +1 more source

Baddeleyite and zircon U-Pb ages of the ultramafic rocks in Chigu Tso area, Southeastern Tibet and their constraints on the timing of Comei Large Igneous Province

China Geology, 2020
: A suite of ultramafic and mafic rocks developed in the Chigu Tso area, eastern Tethyan Himalaya. Baddeleyite and zircon U-Pb ages acquired by SIMS and LA-ICP-MS from olivine pyroxenite rocks in the Chigu Tso area are 138.9±3.0 Ma and 139.0±1.9 Ma ...
Ya-ying Wang, Ling-sen Zeng, Ling-hao Zhao, Li-e Gao, Jia-hao Gao, Zhao-ping Hu, Hai-tao Wang, Guang-xu Li, Ying-long Di, Yu Shen, Qian Xu   +10 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Concordant Rb-Sr and Sm-Nd Ages for NWA 1460: A 340 Ma Old Basaltic Shergottite Related to Lherzolitic Shergottites [PDF]

, 2006
Preliminary Rb-Sr and Sm-Nd ages reported by [1] for the NWA 1460 basaltic shergottite are refined to 336+/-14 Ma and 345+/-21 Ma, respectively. These concordant ages are interpreted as dating a lava flow on the Martian surface.
Irving, A. J., Nyquist, L. E., Reese, Y. D., Shih, C-Y   +3 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

In situ rutile U-Pb dating by laser ablation-MC-ICPMS

GEOCHEMICAL JOURNAL, 2013
Copyright © 2013 by The Geochemical Society of Japan. et al. (2007), Zack et al. (2011) and Kooijman et al. (2010). This method is limited to rutile grains with sufficient U in order to get suitable Pb signal intensity (Zack et al., 2011). It is well known that multi collector ICPMS offers advantages in terms of higher sensitivity, flat top peak shape ...
Ren, Z, Xia, X, Wei, G, Zhang, L, Sun, M, Wang, Y   +5 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Recycling Argon through Metamorphic Reactions: the Record in Symplectites [PDF]

, 2018
The 40Ar/39Ar ages of metamorphic micas that crystallized at high temperatures are commonly interpreted as cooling ages, with grains considered to have lost 40Ar via thermally-driven diffusion into the grain boundary network.
Allaz, Anderson, Anderson, Baxter, Beltrando, Berry, Blundy, Bryhni, Christopher S. McDonald, Clare J. Warren, Connolly, Cuthbert, Dale, Daniele Regis, de Sigoyer, Di Vincenzo, Dodson, Dransfield, Engvik, Eskola, Frost, Fuhrman, Gee, Gilotti, Godard, Groppo, Hacker, Hacker, Hacker, Hacker, Heinrich, Holland, Holland, Holland, Holland, Holland, Holland, Johnson, Kellett, Krogh, Kylander-Clark, Kylander-Clark, Labrousse, Li, Li, Lux, McDonald, Mulch, Peterman, Putlitz, Renne, Roberts, Root, Root, Sarah C. Sherlock, Schmidt, Schärer, Sherlock, Simon P. Kelley, Smith, Spencer, Tajcmanová, Terry, Terry, Tucker, Villa, Villa, Wain, Wain, Walsh, Walsh, Walsh, Warren, Warren, Warren, Watson, Wheeler, White, White, Whitney, Young, Young, Young   +82 more
core   +2 more sources

Coupled Zircon-Rutile U-Pb Chronology: LA ICP-MS Dating, Geological Significance and Applications to Sediment Provenance in the Eastern Himalayan-Indo-Burman Region

Geosciences, 2019
U-Pb dating by LA ICP-MS is one of the most popular and successful isotopic techniques available to the Earth Sciences to constrain timing and rates of geological processes thanks to its high spatial resolution, good precision (absolute U/Pb age ...
Laura Bracciali
doaj   +1 more source