Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
P-T-t path for the Archean Pikwitonei Granulite Domain and Cross Lake Subprovince, Manitoba, Canada [PDF]
The rationale was outlined for constructing pressure-temperature-time (P-T-t) paths by using U-Pb dating of garnet produced in thermobarometrically sensitive reactions. In an example from the Pikwitonei granulites of the Northwestern Superior Province of
Bohlen, S. R., Hanson, G. N., Mezger, K.
core +1 more source
New insights from U–Pb zircon dating of Early Ordovician magmatism on [PDF]
, 2008 The Central Iberian–Ossa-Morena transition zone (SW Iberian Massif) represents a segment of the northern Gondwana margin with a long geodynamic evolution, characterized by the superposition of Cadomian and Variscan events.
Bea, Fernando +7 more
core
Neoproterozoic subduction along the Ailaoshan zone, South China : geochronological and geochemical evidence from amphibolite [PDF]
, 2014 This study was supported by China Natural Science Foundation (41190073 and 41372198), National Basic Research Program of China (2014CB440901) and Natural Environment Research Council (grant NE/J021822/1).Lenses of amphibolites occur along the Ailaoshan ...
Cai, Yongfeng +6 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Pace of passive margin tectonism revealed by U-Pb dating of fracture-filling calcite. [PDF]
Nat Commun, 2022 Amidon WH +4 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Problem on baddeleyite U-Pb dating using SHRIMP II [PDF]
, 2016 第4回極域科学シンポジウム個別セッション：[OG] 地圏11月14日（木）〜11月15日（金） 国立極地研究所 ３階 ...
堀江 憲路 +3 more
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Electron microprobe dating of lunar zirconolite
Journal of Analytical Science and TechnologyZirconolite is an accessary mineral occurred in the lunar basaltic and granitic rocks and contains relatively high contents of U, Th, and Pb, which is attractive for age dating.
Changkun Park, Hwayoung Kim
doaj +1 more source
Gemological and Chemical Characterization of Gem-Quality Titanite from Morocco
CrystalsTitanite is a widespread accessory mineral in igneous, metamorphic, and hydrothermal rocks, but few comply with gem-grade requirements. Previous studies on Moroccan titanite focused on elementary composition and U-Pb dating.
Yu Yuan +5 more
doaj +1 more source