RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy
Advanced Science, EarlyView.This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu +12 more
wiley +1 more source
Cenomanian-? early Turonian minimum age of the Chubut Group, Argentina: SHRIMP U–Pb geochronology
Journal of South American Earth Sciences, 2014 Abstract Four new SHRIMP U–Pb zircon ages older than 93 Ma from samples of the two uppermost formations accumulated in two different depocenters (Golfo de San Jorge and Canadon Asfalto basins) of the Chubut Group in central Argentinean Patagonia, establish a pre-late Cenomanian-? early Turonian age for the group.
Suarez, Manuel +4 more
openaire +6 more sources
Problem on baddeleyite U-Pb dating using SHRIMP II [PDF]
, 2016 第4回極域科学シンポジウム個別セッション：[OG] 地圏11月14日（木）〜11月15日（金） 国立極地研究所 ３階 ...
堀江 憲路 +3 more
core +1 more source
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang +9 more
wiley +1 more source
U-Pb zircon in situ dating with LA-MC-ICP-MS using a mixed detector configuration
Anais da Academia Brasileira de Ciências, 2012 The LA-MC-ICP-MS method applied to U-Pb in situ dating is still rapidly evolving due to improvements in both lasers and ICP-MS. To test the validity and reproducibility of the method, 5 different zircon samples, including the standard Temora-2, ranging ...
Farid Chemale Jr +5 more
doaj
Per os infectivity of white spot syndrome virus (WSSV) in white-legged shrimp (Litopenaeus vannamei) and role of peritrophic membrane [PDF]
, 2016 As earlier observations on peroral infectivity of WSSV in white-legged shrimp are conflicting, here, a standardized peroral intubation technique was used to examine (i) the role of the physical composition of the viral inoculum and (ii) the barrier ...
Bossier, Peter +5 more
core +1 more source
Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks
Advanced Science, EarlyView.This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen +11 more
wiley +1 more source
High- and Ultrahigh-Pressure Metamorphism in the North Qaidam and South Altyn Terranes, Western China [PDF]
, 2007 The North Qaidam and South Altyn terranes extend approximately 1000 km across the northern Tibetan Plateau, and five localities preserve evidence of Early Paleozoic high-pressure (HP) or ultrahigh-pressure (UHP) metamorphism, including the presence of ...
Bird, D. K. +3 more
core +2 more sources
Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots
Advanced Science, EarlyView.Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley +1 more source
Variscan sourcing of Westphalian (Pennsylvanian) sandstones in the Canobie Coalfield, UK [PDF]
, 2010 The zircon age spectrum in a sample from the Canonbie Bridge Sandstone Formation (Asturian) of southern Scotland contains two main peaks. One is Early Carboniferous in age (348– 318 Ma), and corresponds to the age of igneous activity during the ...
ANDREW MORTON +21 more
core +1 more source