Results 101 to 110 of about 485,931 (261)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Measuring U-space social and environmental impact

U-space will enable urban air mobility (UAM) on a wide scale, facilitating a variety of use cases (e.g., medical and emergency transport, delivery of goods, passenger transport services). Social acceptance and impact on citizens is not completely understood in this growing scenario.
Baena, Miguel, Kuljanin, Jovana, Legriffon, Ingrid, Ganic, Emir, Barrado Muxí, Cristina, Mocholí, David, Ruaud, Elise, Torre Sangrà, David de la   +7 more
openaire   +3 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Harnack inequality for harmonic functions relative to a nonlinear p-homogeneous Riemannian Dirichlet form

Le Matematiche, 2007
We consider a measure valued map α(u) defined on D where D is a subspace of L^p(X,m) with X a locally compact Hausdorff topological space with a distance under which it is a space of homogeneous type.
Marco Biroli, Paola Vernole
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Bessel-type inequalities in semi-Hilbert spaces with applications to operator tuples

Journal of Inequalities and Applications
Consider a non-zero positive operator A on a complex Hilbert space ( H , 〈 ⋅ , ⋅ 〉 ) $(\mathfrak{H}, \langle \cdot , \cdot \rangle )$ . This operator induces an A-semi-inner product defined by ( u ∣ v ) A : = 〈 A u , v 〉 $(u \mid v)_{\mathbf{A ...
Feryal Aladsani, Asmahan Alajyan, Silvestru Sever Dragomir, Kais Feki   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Notes on the U-Space Iteration for Negative Parameters

  This paper investigates the U-space iteration u_{n+1} = u_n^{1/s} e^{-\pi u_n / s^2} for negative parameters s < 0. Let t = -s. The main results are:   1. The local stability boundary t_c ≈ 2.07060658 is derived from the condition |λ| = 1, leading to the transcendental equation t(t-1) = π e^{-(t-1)/(t+1)}. 2.
openaire   +3 more sources

Correlation between Lunar Surface and Exospheric Sodium: Effects of Albedo-driven Temperature on Multilayer Sodium Reservoirs Rather than Surface Abundance Variations

The Astrophysical Journal
Sodium (Na) is a moderately volatile element in the lunar exosphere, released from the surface through thermal and nonthermal processes. We present a combined analysis of Chandrayaan-2 CLASS surface Na abundance, LADEE Ultraviolet–Visible Spectrometer ...
A. Devaraj, S. Narendranath, Sreeja. S. Kartha, Netra S. Pillai   +3 more
doaj   +1 more source