Results 71 to 80 of about 485,931 (261)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A Tactical Conflict Resolution Proposal for U-Space Zu Airspace Volumes. [PDF]
Sensors (Basel), 2021 Jover J, Bermúdez A, Casado R.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Flavored resonant leptogenesis in the U(1)X model
Nuclear Physics BWe study the generation of baryon asymmetry through the flavored resonant leptogenesis in the U(1)X extension of the Standard Model. Being a generalization of the U(1)B-L, U(1)X is an ultraviolet-complete model of the right-handed neutrinos (RHNs), whose
Garv Chauhan
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Double-dual types over the Banach space C(K)
International Journal of Mathematics and Mathematical Sciences, 2005 Let K be a compact Hausdorff space and C(K) the Banach space of all real-valued continuous functions on K, with the sup-norm. Types over C(K) (in the sense of Krivine and Maurey) can be uniquely represented by pairs (ℓ,u) of bounded real-valued functions
Markus Pomper
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
U-space TWICS: A meta U-space service concept to aid developing communications between autonomous uncrewed systems [PDF]
U-space is a regulatory concept for an upcoming air space targeted towards unmanned aerial systems (UAS). It requires an automatic communication of operators with mandatory services in a centralized structure. However, communication directly between UAS also needs to be anticipated.
Krause, Fabian, Nagarajan, Pranav
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source