Results 151 to 160 of about 11,479,816 (281)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Neocirkumfleks u čakavskom narječju

, 2017
U ovoj se knjizi analizira fenomen neocirfkumfleksa u čakavskom. Dva su njezina temeljna cilja. Prvi se odnosi na nastojanje da se precizno definiraju kategorije u kojima u sjeverozapadnom čakavskom dolazi mlađi neocirkumfleks i da se one rasloje na ...
Zubčić, Sanja
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Opatovina-tragovi povijesti izgubljene u sadašnjosti

, 2006
rilikom rekonstrukcije i uređenja Ulice Opatovina 2002. godine pred zapadnim ulazom u crkvu sv. Franje stručnjaci Arheološkog muzeja u Zagrebu otkrili su ostatke kasnosrednjovjekovnog groblja i proveli arheološko iskopavanje.
Demo, Željko
core  

Three positive solutions for m-point boundary-value problems with one-dimensional p-Laplacian

Electronic Journal of Differential Equations, 2011
In this article, we study the multipoint boundary value problem for the one-dimensional p-Laplacian $$ (phi_p(u'))'+ q(t)f(t,u(t),u'(t))=0,quad tin (0,1), $$ subject to the boundary conditions $$ u(0)=sum_{i=1}^{m-2} a_iu(xi_i),quad u'(1)=eta u'(0)
Donglong Bai, Hanying Feng
doaj  

Predicting structure-dependent Hubbard U parameters via machine learning

Materials Futures
DFT + U is a widely used treatment in the density functional theory (DFT) to deal with correlated materials that contain open-shell elements, whereby the quantitative and sometimes even qualitative failures of local and semi-local approximations can be ...
Guanghui Cai, Zhendong Cao, Fankai Xie, Huaxian Jia, Wei Liu, Yaxian Wang, Feng Liu, Xinguo Ren, Sheng Meng, Miao Liu   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source