Results 161 to 170 of about 11,479,816 (281)

Infinitely many solutions for a fourth-order boundary-value problem

open access: yesElectronic Journal of Differential Equations, 2012
In this article we consider the existence of infinitely many solutions to the fourth-order boundary-value problem $$displaylines{ u^{iv}+alpha u''+eta(x) u=lambda f(x,u)+h(u),quad xin]0,1[cr u(0)=u(1)=0,cr u''(0)=u''(1)=0,.
Seyyed Mohsen Khalkhali   +2 more
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Bifurcation from infinity and multiple solutions for first-order periodic boundary-value problems

open access: yesElectronic Journal of Differential Equations, 2011
In this article, we study the existence and multiplicity of solutions for the first-order periodic boundary-value problem $$displaylines{ u'(t)-a(t)u(t)=lambda u(t)+g(u(t))-h(t), quad tin (0, T),cr u(0)=u(T). }$$
Zhenyan Wang, Chenghua Gao
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Logistički menadžment u turizmu

open access: yes, 2010
U vremenima dinamičnog razvitka u kojima težnja za što većim profitom jest dominantno mjerilo uspješnosti, ljudi se suočavaju sa spoznajom da su osim tog moguća i potrebna druga mjerila i ciljevi koji ne dovode u pitanje gospodarstveni i društveni ...
Mrnjavac, Edna
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

SISTEM BEZBEDNOSTI: KARAKTER I VREDNOST ZNANJA U NJEGOVIM PROIZVODIMA: STUDIJA REPUBLIKA SRBIJA-THE SECURITY SYSTEM OF THE REPUBLIC OF SERBIA: THE CHARACTER AND VALUE OF KNOWLEDGE IN ITS PRODUCTS

open access: yes
U naučnom, teorijskom, profesionalnom i stvarnom životu sistema bezbednosti u jednom društvu, do sada nismo imali priliku da govorimo o njegovom karakteru–dobrom ili lošim, značajnom ili slabom – i shvatamo o tome kako se značajna vrednost i koliko se ...
Dragan, Manojlović   +3 more
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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