Results 71 to 80 of about 13,111 (148)

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Harold Bae, Catherine E Costello, Matthew Au, Lingyi Lynn Deng, Mengze Li, Qingyan Xiang, Heeju Noh, Lance Pflieger, Cory Funk, Noa Rappaport, Marianne Nygaard, Meghan I Short, Michael Brent, Stefano Monti, Stacy L Andersen, Thomas T Perls   +20 more
wiley   +1 more source

Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. [PDF]

, 2016
High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine ...
Baechler, Emily C, Balboni, Imelda M, Diep, Vivian K, Haddon, D James, Hall, Drew A, Lee, Jung-Rok, Petri, Michelle, Price, Jordan V, Utz, Paul J, Wand, Hannah E, Wang, Shan X   +10 more
core   +2 more sources

Characterizing amyloid and tau positron emission tomography‐based stages across the clinical continuum

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION We standardized positron emission tomography (PET) data across multiple cohorts and tracers to characterize the frequency of amyloid and tau PET severity along the clinical continuum. METHODS Clinical stage was defined using cohort‐specific criteria and included cognitively unimpaired (CU), mild cognitive impairment (MCI), and ...
Karly A. Cody, Andrzej Sokołowski, Emily Johns, Lucah Medina Guerra, Joseph R. Winer, Christina B. Young, Kyan Younes, Logan Dumitrescu, Derek B. Archer, Alaina Durant, Aditi Sathe, Mary Ellen I. Koran, Jesse Mez, Andrew J. Saykin, Arthur Toga, Michael Cuccaro, Duygu Tosun, Philip S. Insel, Sterling C. Johnson, Theresa M. Harrison, Timothy J. Hohman, Elizabeth C. Mormino   +21 more
wiley   +1 more source

Estimating Mangrove Biophysical Variables Using WorldView-2 Satellite Data: Rapid Creek, Northern Territory, Australia

Journal of Imaging, 2016
Mangroves are one of the most productive coastal communities in the world. Although we acknowledge the significance of ecosystems, mangroves are under natural and anthropogenic pressures at various scales.
Muditha K. Heenkenda, Stefan W. Maier, Karen E. Joyce   +2 more
doaj   +1 more source

Differences in the performance tests of the fast and slow stretch and shortening cycle among professional, amateur and elite youth soccer players [PDF]

, 2015
The purpose of this study was to establish whether physical attributes can differentiate between professional, amateur and elite youth soccer players; such a distinction could aid in the selection process for youth soccer.
Hartmann, Hagen, Keiner, Michael, Sander, Andre, Wirth, Klaus   +3 more
core   +1 more source

Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION “SuperAgers” are oldest‐old adults (ages 80+) whose memory performance more closely resembles middle‐aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non‐Hispanic Black (NHB) and non‐Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases.
Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Brandon S. Klinedinst, Emily H. Trittschuh, Jesse Mez, Lindsay A. Farrer, Katherine A. Gifford, Carlos Cruchaga, Jason Hassenstab, Adam C. Naj, Li‐San Wang, Sterling C. Johnson, Corinne D. Engelman, Walter A. Kukull, C. Dirk Keene, Andrew J. Saykin, Michael L. Cuccaro, Brian W. Kunkle, Margaret A. Pericak‐Vance, Eden R. Martin, David A. Bennett, Lisa L. Barnes, Julie A. Schneider, William S. Bush, Jonathan L. Haines, Richard Mayeux, Badri N. Vardarajan, Marilyn S. Albert, Paul M. Thompson, Angela L. Jefferson, The Alzheimer's Disease Neuroimaging Initiative (ADNI)*Alzheimer's Disease Genetics Consortium (ADGC)The Alzheimer's Disease Sequencing Project (ADSP), Paul K. Crane, Logan Dumitrescu, Derek B. Archer, Timothy J. Hohman, Leslie S. Gaynor   +38 more
wiley   +1 more source

Neuroinflammation demonstrated by 11C‐ER176 PET with amyloid and tau pathology

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Understanding neuroinflammation across the Alzheimer's disease (AD) spectrum is essential to elucidate disease mechanisms and individualize therapy. METHODS Human microglial translocator protein (TSPO) expression under inflammatory stimuli was assessed by immunoblot experiments.
Mahathi Kandimalla, Seokbeen Lim, David N. Jacobson, Jeyeon Lee, Paul H. Min, Marin E. Nycklemoe, Seung Baek Lee, Emily S. Lundt, Hugo Botha, Jonathan Graff‐Radford, David T. Jones, Petrice M. Cogswell, Prashanthi Vemuri, Kejal Kantarci, David S. Knopman, Clifford R. Jack Jr., Ronald C. Petersen, Val J. Lowe   +17 more
wiley   +1 more source

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Adults with Down syndrome (DS) display increased Alzheimer's disease (AD) risk. The cholinergic system declines early in the AD continuum and relates to cognitive and functional decline. We aimed to identify the timeline of cholinergic decline in relation to hippocampal atrophy within the AT(N) framework in DS.
Jason K. Russell, Zinayida Schlachetzki, Alexander C. Conley, Brian D. Boyd, Paul A. Newhouse, Paul S. Aisen, Michael S. Rafii, for the Alzheimer's Biomarker Consortium on Down Syndrome Study   +7 more
wiley   +1 more source

There are Plane Spanners of Maximum Degree 4

, 2014
Let E be the complete Euclidean graph on a set of points embedded in the plane. Given a constant t >= 1, a spanning subgraph G of E is said to be a t-spanner, or simply a spanner, if for any pair of vertices u,v in E the distance between u and v in G is ...
Bonichon, Nicolas, Kanj, Iyad, Perković, Ljubomir, Xia, Ge   +3 more
core   +2 more sources

Gray matter microstructure from in vivo diffusion magnetic resonance imaging reflects post mortem neuropathology severity and clinical progression of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Diffusion‐weighted imaging derived mean diffusivity (MD) correlates with Alzheimer's disease (AD) biomarkers, yet its neuropathological correlates remain unclear. METHODS Diffusion‐weighted imaging, post mortem neuropathology, and cognitive performance data were obtained from the National Alzheimer's Coordinating Center (N = 97 ...
Zaki Alasmar, Cécilia Tremblay, Roqaie Moqadam, Geidy E Serrano, Thomas G Beach, Alireza Atri, Yi Su, for the Alzheimer's Disease Neuroimaging Initiative, Yashar Zeighami, Mahsa Dadar   +9 more
wiley   +1 more source