Results 121 to 130 of about 23,643 (220)
The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo [PDF]
, 2012 Background: Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior
Ding, Jianbo +8 more
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Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells
Cellular & Molecular Biology Letters, 2017 Background Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are involved in the development of glioma,
Jian Ge +5 more
doaj +1 more source
ACSVL3 depletion in U87 glioma cells affects both fatty acid and cholesterol homeostasis
The FASEB Journal, 2010 Human malignant gliomas overexpress ACSVL3, a member of the very long‐chain fatty acyl‐CoA synthetase family. Depletion of ACSVL3 in cultured human U87 glioma cells by RNA interference decreased both their malignant growth properties in vitro and their ability to produce tumors in mice ...
Paul Watkins +2 more
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MiR-320 inhibits the growth of glioma cells through downregulating PBX3
Biological Research, 2017 Background MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been
Cuicui Pan +5 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2016 Objective To investigate whether Rac1 inhibitor has a synergistic effect on temozolomide (TMZ) in inhibiting the proliferation, migration and invasiveness of glioma cells. Methods Human glioma cell lines U87 and U251 were cultured by Rac1 inhibitor,
Xiao-yong HAN +5 more
doaj
Predictive effect of γH2AX expression on the radiosensitivity of glioma
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 Objective To observe the expression changes of γH2AX in high-grade glioma cell lines (U87, U251 and LN229) and to investigate the relationship between the expression of γ H2AX and the radiosensitivity of high-grade glioma cells in vitro. Methods The
Jun-wei WANG +4 more
doaj
Activation of PTGS2/NF‐κB signaling pathway enhances radiation resistance of glioma
Cancer Medicine, 2019 Objective We focused on the effects of PTGS2/NF‐κB signaling pathway on the radiation resistance of glioma in the study. Methods We downloaded the microarray data from the Gene Expression Omnibus (GEO) database.
Cheng Tan +7 more
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Abstract 1234: Untargeted Lipidomics in U87-MG Glioma Cells
Journal of Biological Chemistry, 2023 Grace Chao +3 more
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Promising fusion protein design to target the U87 MG glioma cell line.
Asian Pacific journal of cancer prevention : APJCP, 2012 Gliomas, with a poor clinical course, account for 30% to 40% of all intracranial tumors. Immunotherapy with monoclonal antibodies has emerged as a promising area of investigation and recently it has been shown that antibodies utilize complementarity-determining regions (CDRs) of their variable domains to bind to antigens with high affinity and ...
Chen, Jing +6 more
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Metalloproteases involved in the Temozolomide (TMZ) resistance of U87-MG glioma cells
, 2013 Glioblastoma multiforme (GBM) is the most malignant type of brain tumours bearing a grim prognosis with a median survival of 14.8 months. Despite therapeutic advances over the past decades, GBM treatment remains ineffective with temozolomide (TMZ) as a standard chemotherapeutic agent. Even using TMZ combined with surgical
openaire +3 more sources