Results 111 to 120 of about 23,643 (220)

Systemic Propagation of STING Signalling via Generation of Large Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Large extracellular vesicles (EVs) derived from tumour cells play important roles in tumour formation and progression. However, it remains unclear why malignant cells produce these EVs and how they act in vivo. We employ a well‐characterized Drosophila tumour model and demonstrate that large EV biogenesis from malignant cells is an ...
Jiae Lee, Annabel Vernon, Hyung Joon Park, Young V. Kwon   +3 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Curcumin Enhances the Radiosensitivity of U87 Cells by Inducing DUSP-2 Up-Regulation

Cellular Physiology and Biochemistry, 2015
Objective: Glioblastoma multiforme (GBM), an aggressive primary brain tumor, is radioresistant and recurs despite aggressive surgery, chemotherapy, and radiotherapy.
Yu Qian, Jianfen Ma, Xiaoyi Guo, Jun Sun, Yongtao Yu, Boqiang Cao, Lei Zhang, Xiaopeng Ding, Jin Huang, Jun Fei Shao   +9 more
doaj   +1 more source

Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest. [PDF]

Evid Based Complement Alternat Med, 2022
Alharthy SA, Alharthy SA, Tabrez S, Mirza AA, Zughaibi TA, Firoz CK, Dutta M.   +6 more
europepmc   +1 more source

The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley   +1 more source

L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells

Cancer Science, Volume 117, Issue 5, Page 1380-1396, May 2026.
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma, Daisuke Kanematsu, Yukako Handa, Tomoko Shofuda, Atsuyo Yamamoto, Kayo Nishitani, Zhize Xiao, Daisuke Kawauchi, Kentarou Baba, Naoyuki Inagaki, Yonehiro Kanemura   +10 more
wiley   +1 more source

GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway

Frontiers in Genetics
BackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie, Shao Xie, Jiahai Ding, Zhaohao Wang, Hengliang Shi, Zheng-Quan Yu   +5 more
doaj   +1 more source

TAS102 selectively inhibits proliferation of α-thalassemia mental retardation X-linked gene-deficient glioma cells

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of TAS102 on the proliferation of α-thalassemia mental retardation X-linked (ATRX)-deficient U87 glioma cells in vitro and explore the mechanism. Methods Wild-type glioma U87 cells and ATRX knockout U87 cells (U87ATRX-/
WANG Long, JIANG Hang, CHEN Tunan, LI Xuegang, HUANG Suna   +4 more
doaj   +1 more source

In Vitro Evaluation of PARP1 Inhibitor Olaparib‐Cyanine Dye Conjugate for the Treatment of Glioblastoma

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo, Faheem, Peter J. Choi, Nicholas J. Pederson, Yuge Liu, Mike Dragunow, Thomas I‐H. Park, Katharine L. Diehl, Jiney Jose   +8 more
wiley   +1 more source

Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells

International Journal of Molecular Medicine, 2018
Photodynamic therapy (PDT) is a relatively novel type of tumor therapy method with low toxicity and limited side‑effects. The aim of the present study was to investigate the underlying mechanism and potential microRNAs (miRNAs) involved in the treatment of glioma by PDT with hematoporphyrin, a clinical photosensitizer.
Shi-Xiang, Yuan, Jun-Liang, Li, Xin-Ke, Xu, Wei, Chen, Cheng, Chen, Kun-Qi, Kuang, Fang-Yu, Wang, Kai, Wang, Fang-Cheng, Li   +8 more
openaire   +3 more sources