Results 1 to 10 of about 4,884,325 (258)

GLUTAMINE DEPRIVATION AFFECTS THE EXPRESSION OF GENES WHICH CONTROL PYRUVATE DEHYDROGENASE ACTIVITY: THE IMPACT OF ERN1 KNOCKDOWN [PDF]

Biotechnologia Acta, 2022
The aim of the current investigation was to study the expression of genes encoded pyruvate dehydrogenase subunits (PDHA1, PDHB, PDHX, DLAT, and DLD) in U87 glioma cells in response to glutamine deprivation in U87 glioma cells in relation to knockdown of ...
M. Sliusar, H. Shatokhina, A. Cherednychenko, O. Minchenko   +3 more
doaj   +1 more source

The impact of glutamine deprivation on the expression of MEIS3, SPAG4, LHX1, LHX2, and LHX6 genes in ERN1 knockdown U87 glioma cells

Endocrine Regulations, 2022
Objective. The aim of the current study was to investigate the expression of genes encoded homeobox proteins such as MEIS3 (Meis homeobox 3), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1), LHX2, and LHX6 in U87 glioma cells in response to ...
Krasnytska Dariia A., Khita Olena O., Tsymbal Dariia O., Luzina Olha Y., Cherednychenko Anastasiia A., Kozynkevich Halyna E., Bezrodny Borys H., Minchenko Dmytro O.   +7 more
doaj   +1 more source

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

OncoImmunology, 2021
Immune checkpoint blockade (ICB) expands the therapeutic options for metastatic lung cancer nowadays representing a standard frontline strategy as monotherapy or combination therapy, as well as an option in oncogene-addicted NSCLC after exhaustion of ...
Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Stefan Fröhling, Solange Peters, Barbara Seliger, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger   +18 more
doaj   +1 more source

Effect of all-trans retinoic acid on casein and fatty acid synthesis in MAC-T cells [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective Caseins and fatty acids of milk are synthesized and secreted by the epithelial cells of the mammary gland. All-trans retinoic acid (ATRA), an active metabolite of vitamin A, has been shown to promote mammary development.
Xian-Dong Liao, Chang-Hai Zhou, Jing Zhang, Jing-Lin Shen, Ya-Jing Wang, Yong-Cheng Jin, Sheng-Li Li   +6 more
doaj   +1 more source

Expression of the VEGF, Glut1 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4 in human cancers of the lung, colon and stomach

Біологічні студії, 2009
Expression of vascular endothelial growth factor (VEGF), glucose transporter Glut1 and two members of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase family (PFKFB-3 and PFKFB-4) in lung, colon and gastric cancers was studied.
D. O. Minchenko, A. Y. Bobarykina, T. Y. Senchenko, O. V. Hubenya, K. Tsuchihara, A. Ochiai, M. Moenner, H. Esumi, O. H. Minchenko   +8 more
doaj   +1 more source

The role of three heat shock protein genes in the immune response to Aeromonas hydrophila challenge in marbled eel, Anguilla marmorata [PDF]

Royal Society Open Science, 2016
Heat shock proteins (HSPs) are highly conserved molecular chaperones that play critical roles in both innate and adaptive immunity. However, little information about HSPs from marbled eel Anguilla marmorata is known.
Fenfei Liang, Guosong Zhang, Shaowu Yin, Li Wang   +3 more
doaj   +1 more source

Down-regulation of zinc levels in children patients with pityriasis simplex: association with the oxidative stress pathway?

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To assess serum levels of zinc in children patients with pityriasis alba (PA) and study mRNA expression profile of oxidative stress pathway by bioinformatics technology to investigate the relationship between oxidative stress and PA.
Xianhua TANG, Chao CHEN, Longmao WU, Huotao LI, Xia XU, Yuqiong DENG   +5 more
doaj   +1 more source

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes

Nature Communications, 2017
The BioID approaches takes advantage of the promiscuous biotinylation enzyme (BirA*) to identify proteins that closely interact. Here the authors improve the resolution of BioID using a protein fragment complementation approach that allows the assignment
Isabel Myriam Schopp, Cinthia Claudia Amaya Ramirez, Jerneja Debeljak, Elisa Kreibich, Merle Skribbe, Klemens Wild, Julien Béthune   +6 more
doaj   +1 more source

Chinese herbal Jin-Ying-Tang attenuates the inflammatory response by inhibiting the activation of TLR4/MyD88/TRAF-6/NIK pathway at the mRNA level in LPS-stimulated mouse mammary epithelial cells

Journal of Veterinary Research, 2016
Introduction: The effects of Jin-Ying-Tang (JYT) on Toll-like Receptor 4 (TLR4) signalling transduction of lipopolysaccharide (LPS)-stimulated mouse mammary epithelial cells (MECs) in vitro were examined.
Yi Qiong, Li Xin, Li Yuan-Fang, Yang Hang, Zhang Xiao-Yi, Ma Zhe, Wang Lu   +6 more
doaj   +1 more source

cDNA Cloning and mRNA Expression of Androgen Receptor in Male Japanese Quail (Coturnix coturnix japonica)

The Journal of Poultry Science, 2006
The biological activities of androgen are largely mediated via androgen receptor (AR). Although a partial sequence AR cDNA was revealed in canaries and zebra finch, AR cDNA has not been cloned in quail and chickens.
Shusei Mizushima, Noboru Saito, Kiyoshi Shimada   +2 more
doaj   +1 more source