Glucose deprivation impairs hypoxia-inducible factor-1α synthesis [PDF]
Discover OncologyHypoxia-inducible factors (HIFs) are key transcriptional mediators of the hypoxic response and are implicated in oncogenesis. HIFα is regulated by a well-characterized, oxygen-dependent degradation pathway involving the von Hippel Lindau (VHL) tumor ...
Mia Hubert, Sarah Stuart, Michael Ohh
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Flurbiprofen ameliorates glucose deprivation-induced leptin resistance [PDF]
Frontiers in Pharmacology, 2016 Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi +3 more
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Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation. [PDF]
PLoS ONE, 2018 Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Courtney Sobieski +3 more
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ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation [PDF]
Cell Death DiscoveryMetabolic plasticity sustains glioblastoma (GBM) survival under nutrient stress, yet how fructolytic adaptation compensates for glucose deprivation remains unclear.
Yingping Li +6 more
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Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma. [PDF]
Cancer Res, 2023 Abstract Increased utilization of glucose is a hallmark of cancer. Sodium-glucose transporter 2 (SGLT2) is a critical player in glucose uptake in early-stage and well-differentiated lung adenocarcinoma (LUAD).
Saggese P +14 more
europepmc +4 more sources
Photothermal imaging of cellular responses to glucose deprivation. [PDF]
RSC Chem BiolCellular responses to glucose deprivation in live cancer cells were visualised using multi-wavelength photothermal microscopy without the use of labelling molecules.
Miyazaki J, Wagatsuma R, Okamoto K.
europepmc +3 more sources
Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation [PDF]
Cell Death and DiseaseProtein kinase AKT plays a broad role in promoting energy production in nutrient-rich environments. However, its roles under metabolic stress remain elusive. Herein, we demonstrate a dual mechanism for AKT activation during glucose deprivation.
Guang-xi Yang +8 more
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陆军军医大学学报Objective To investigate the protective effect of oxygen-glucose deprivation preconditioning (OGDPC) on PC12 cells damaged with oxygen-glucose deprivation/reperfusion (OGD/R) and its underlying mechanism.
HUANG Li, HUANG Li, XU Na, YANG Chaoxian
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Effects of daytime food intake on memory consolidation during sleep or sleep deprivation. [PDF]
, 2012 Sleep enhances memory consolidation. Bearing in mind that food intake produces many metabolic signals that can influence memory processing in humans (e.g., insulin), the present study addressed the question as to whether the enhancing effect of sleep on ...
Benedict, Christian +6 more
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Glucose deprivation-induced glycogen degradation and viability are altered in peripheral blood mononuclear cells of type 2 diabetes patients [PDF]
The Ukrainian Biochemical Journal, 2022 The glycogen pathway plays an important role in glucose homeostasis. Impairment of the glycogen pathway has been linked to diabetes mellitus. The aim of the study is to compare the levels of glucose deprivation-induced glycogen degradation and cell ...
K. S. Praveen Kumar +2 more
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