TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling [PDF]
Current Issues in Molecular BiologyGlucose deprivation is a major metabolic stress that requires coordinated adaptive responses to maintain cellular homeostasis and survival, yet the role of tripartite motif-containing 24 (TRIM24) in this process remains unclear. To address this question,
Xiaochen Yu +9 more
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ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation [PDF]
Cell Death DiscoveryMetabolic plasticity sustains glioblastoma (GBM) survival under nutrient stress, yet how fructolytic adaptation compensates for glucose deprivation remains unclear.
Yingping Li +6 more
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Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation [PDF]
Cell Death and DiseaseProtein kinase AKT plays a broad role in promoting energy production in nutrient-rich environments. However, its roles under metabolic stress remain elusive. Herein, we demonstrate a dual mechanism for AKT activation during glucose deprivation.
Guang-xi Yang +8 more
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Glucose deprivation impairs hypoxia-inducible factor-1α synthesis [PDF]
Discover OncologyHypoxia-inducible factors (HIFs) are key transcriptional mediators of the hypoxic response and are implicated in oncogenesis. HIFα is regulated by a well-characterized, oxygen-dependent degradation pathway involving the von Hippel Lindau (VHL) tumor ...
Mia Hubert, Sarah Stuart, Michael Ohh
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Glucose deprivation-induced glycogen degradation and viability are altered in peripheral blood mononuclear cells of type 2 diabetes patients [PDF]
The Ukrainian Biochemical Journal, 2022 The glycogen pathway plays an important role in glucose homeostasis. Impairment of the glycogen pathway has been linked to diabetes mellitus. The aim of the study is to compare the levels of glucose deprivation-induced glycogen degradation and cell ...
K. S. Praveen Kumar +2 more
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Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2. [PDF]
PLoS ONE, 2013 Glucose is one of the most important sources of cellular nutrition and glucose deprivation induces various cellular responses. In Schizosaccharomyces pombe, zinc finger protein Rst2 is activated upon glucose deprivation, and regulates gene expression via
Toshiaki Kato, Xin Zhou, Yan Ma
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N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine attenuates oxygen-glucose deprivation and reoxygenation-induced cerebral ischemia-reperfusion injury via regulation of microRNAs [PDF]
Journal of Integrative Neuroscience, 2020 Cerebral ischemia-reperfusion injury is a common complication that occurs during stroke treatment. Increasingly, microRNAs have been found to participate in the modulation of neuron function; however, the role of microRNAs in cerebral ischemia ...
Tiansong Yang, Dongyan Wang, Yuanyuan Qu, Yulin Wang, Yuenan Feng, Yan Yang, Qiang Luo, Xiaowei Sun, Guoqiang Yu, Jia He, Zhongren Sun, Yulan Zhu
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Repeated Glucose Deprivation/Reperfusion Induced PC-12 Cell Death through the Involvement of FOXO Transcription Factor [PDF]
Diabetes & Metabolism Journal, 2016 BackgroundCognitive impairment and brain damage in diabetes is suggested to be associated with hypoglycemia. The mechanisms of hypoglycemia-induced neural death and apoptosis are not clear and reperfusion injury may be involved.
Na Han +13 more
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ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation
Cells, 2020 xCT, also known as solute carrier family 7 member 11 (SLC7A11), the light chain of the cystine/glutamate antiporter, is positively correlated with cancer progression due to antioxidant function.
Mei-Chun Chen +5 more
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Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation. [PDF]
PLoS ONE, 2018 Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Courtney Sobieski +3 more
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