Results 31 to 40 of about 181,947 (306)

Glucose deprivation in tuberous sclerosis complex-related tumors [PDF]

Cell & Bioscience, 2011
Abstract Background Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependence in tumors.
Jiang Xiuyun, Kenerson Heidi L, Yeung Raymond S   +2 more
openaire   +3 more sources

Inhibition of IRE1 modifies effect of glucose deprivation on the expression of TNFα-related genes in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2015
Inhibition of IRE1 (inositol requiring enzyme-1), the major signaling pathway of endoplasmic reticulum stress, significantly decreases glioma cell proliferation and tumor growth.
I. V. Kryvdiuk, D. O. Minchenko, N. A. Hlushchak, O. O. Ratushna, L. L. Karbovskyi, O. H. Minchenko   +5 more
doaj   +1 more source

Glucose deprivation neuronal injury in cortical culture

Brain Research, 1989
Murine cortical cell cultures deprived of glucose for 6-8 h developed extensive neuronal degeneration, apparent both morphologically and by efflux of lactate dehydrogenase to the bathing medium. This neuronal damage could be substantially reduced by addition of D-2-amino-5-phosphonovalerate (D-APV), in a concentration-dependent (IC50 about 2 microM ...
H, Monyer, M P, Goldberg, D W, Choi
openaire   +2 more sources

Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation

Neurobiology of Disease, 2012
The use of energy substrates, such as lactate and pyruvate, has been shown to improve synaptic function when administered during glucose deprivation. In the present study, we investigated whether prolonged incubation with monocarboxylate (pyruvate or ...
Pavan K. Shetty, Matthew P. Sadgrove, Francesca Galeffi, Dennis A. Turner   +3 more
doaj   +1 more source

Food after deprivation rewards the earlier eating [PDF]

, 2005
Food intake can be increased by learning to anticipate the omission of subsequent meals. We present here a new theory that such anticipatory eating depends on an associative process of instrumental reinforcement by the nutritional repletion that occurs ...
David A. Booth, Soghra Jarvandi, Louise Thibault, Abizaid, Ackroff, Ackroff, Baker, Baker, Baker, Balleine, Berridge, Birch, Blair, Boggiano, Booth, Booth, Booth, Booth, Booth, Booth, Booth, Booth, Booth, Booth, Brunstrom, Brunstrom, Cameron, Cohen, Conner, Dibsdall, Epstein, Garcia, Garrow, Gerozissis, Gibson, Greenwood, Grice, Herman, Herman, Holman, Jarvandi, Jarvandi, Jarvandi, Jarvandi, Le Magnen, Le Magnen, Mather, Miller, Miller, Nachman, Newman, Olszewski, Pliner, Polivy, Revusky, Revusky, Sclafani, Sclafani, Sclafani, Sclafani, Simmons, Simson, Simson, Stice, Stice, Thibault, Thomas, Tomiyama, Wang, Wansink, Weingarten, White, WHO, Wickelgren, Wise, Woods, Zentall   +76 more
core   +3 more sources

Regulation of brain glucose transporters by glucose and oxygen deprivation

Metabolism, 1999
Brain cells are dependent on glucose and oxygen for energy. We investigated the effects of hypoxia, glucose deprivation, and hypoxia plus glucose deprivation on mRNA and protein levels of glucose transporter (GLUT1) and GLUT3 and 2-deoxyglucose (2-DG) uptake in primary cultures of rat neurons and astroglia.
Departments of Medicine (Division of Endocrinology and Metabolism), Physiology, and Biochemistry and Molecular Biology, University of Florida, College of Medicine, Gainesville, FL, USA ( host institution ), Bruckner, Brian A. ( author ), Ammini, Chandramohan V. ( author ), Otal, Marissa P. ( author ), Raizada, Mohan K. ( author ), Stacpoole, Peter W. ( author )   +5 more
openaire   +3 more sources

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]

, 2017
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel, Christofk, Heather, Clark, Peter M, Ding, Xueqin, Dunham, Christopher, Fu, Kai, Gimzewski, James K, Kurdistani, Siavash K, Lusis, Aldons J, Minami, Itsunari, Morselli, Marco, Nakano, Atsushi, Nakano, Haruko, Nakatsuji, Norio, Pappoe, Herman, Pellegrini, Matteo, Reue, Karen, Ribalet, Bernard, Sagadevan, Addelynn, Stieg, Adam Z, Vergnes, Laurent, Wu, Xiuju   +21 more
core   +2 more sources

Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake. [PDF]

PLoS ONE, 2010
Glucose homeostasis is maintained by a balance between hepatic glucose production and peripheral glucose utilization. In skeletal muscle cells, glucose utilization is primarily regulated by glucose uptake.
Jong Hyun Kim, Ji-Man Park, Kyungmoo Yea, Hyun Wook Kim, Pann-Ghill Suh, Sung Ho Ryu   +5 more
doaj   +1 more source

Prediction of cardiovascular disease risk by cardiac biomarkers in 2 United Kingdom cohort studies: does utility depend on risk thresholds for treatment? [PDF]

, 2016
We tested the predictive ability of cardiac biomarkers N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T, and midregional pro adrenomedullin for cardiovascular disease (CVD) events using the British Regional Heart Study ...
Hart, Carole, McConnachie, Alex, Murray, Heather, Papacosta, Olia, Preiss, David, Ramsay, Sheena, Sattar, Naveed, Upton, Mark, Wannamethee, Goya, Watt, Graham, Welsh, Paul, Whincup, Peter   +11 more
core   +1 more source