Results 1 to 10 of about 11,924 (139)

The IRE1-XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5-HT Dependent Endogenous Anti-Autophagy Mechanism. [PDF]

Adv Sci (Weinh)
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Yang P, Zhu B, He Y, Tian Y, Kang H, Hu S, Wang P, Xu Y, Lei Z, Qi P, Yang H, Lin Y, Dong Y, Li F, Guan H.   +14 more
europepmc   +2 more sources

IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes [PDF]

Arthritis Research & Therapy
Background Rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) exhibit chronic endoplasmic reticulum stress with activation of the IRE1/phospho‑JNK arm of the unfolded protein response; yet, they remain resistant to apoptosis. Although ferroptosis
Jiaxi Liu, Wenhui Xie, Yongping Cao, Liang Zhang, Yan Geng, Zhuoli Zhang   +5 more
doaj   +2 more sources

The mannosyltransferase DPM1 regulates the activity of ER-stress sensor IRE1 in colorectal cancer [PDF]

Nature Communications
Most colorectal cancer (CRC) patients exhibit resistance to immune checkpoint blockade (ICB), limiting treatment efficacy. Activating the unfolded protein response sensor IRE1α in cancer cells can induce anticancer immune responses, yet its regulation ...
Hussein Issaoui, Lina Zawil, Lola Bellone, Diogo Goncalves, Rachel Paul, Léa Di Mascio, Sonia Núñez-Vázquez, Sandrine Marchetti, Johanna Chiche, Nicolas Nottet, Simon Le Goupil, Hadrien Laprade, Lucile Bansard, Yourae Hong, Rebecca Wall, Sabine Tejpar, Caroline Truntzer, François Ghiringhelli, Suresh Poudel, Helen M. Beere, Douglas R. Green, Julie Pannequin, Eric Chevet, Jean-Ehrland Ricci   +23 more
doaj   +2 more sources

A Specific tRNA Half, 3'tiRNA-GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf-Mediated Endoplasmic Reticulum Stress. [PDF]

Cell Prolif
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Zhang L, Guan X, Zhu X, Hao Y, Xu Y, Yuan H, Gao D, Du H, Li J, Cao W, Ma C, Wang X.   +11 more
europepmc   +2 more sources

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Nature Communications, 2018
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to ...
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali   +18 more
doaj   +2 more sources

Free Fatty Acids Induce Endoplasmic Reticulum Stress-Mediated Apoptosis of Macrophages in Dairy Cows with Ketosis [PDF]

Animals
Dairy cows with ketosis display immune dysfunction and a high incidence of infectious diseases, which may partly be attributed to excessive endoplasmic reticulum stress (ERS) and apoptosis in macrophages.
Hongdou Jia, Xinyuan Sun, Wantong Cheng, Yue Yu, Yutong Wu, Jiayi Yan, Yunhui Fan, Qiushi Xu, Juan J. Loor, Chuang Xu, Shixin Fu, Xudong Sun   +11 more
doaj   +2 more sources

Oncoprotein CYB561, acting in IRE1-XBP1-SREBF1 and FAK-ERK pathway, promotes breast cancer lipogenesis and progression [PDF]

Cell Death Discovery
Breast cancer (BC) heterogeneity, particularly in triple-negative (TNBC) and HER2-positive subtypes, underpins therapeutic challenges and cancer-related mortality worldwide.
Xiaochen Yang, Yukai Tao, Yan Xu, Qixiang Shao, Guoqin Jiang   +4 more
doaj   +2 more sources

BvrR From Brucella abortus Induces Neuroinflammation Through IRE1‐Mediated Activation of ATF2 and NF‐κB [PDF]

MicrobiologyOpen
Brucella‐induced neuroinflammation represents a key mechanism in the development of neurobrucellosis. The objective of this investigation was to clarify the molecular pathways through which the BvrR contributes to neuroinflammation and cognitive ...
Zhao Wang, Xinwen Yu, Boyu Liu, Dongni Ren   +3 more
doaj   +2 more sources

Expression of IGFBP6, IGFBP7, NOV, CYR61, WISP1 and WISP2 genes in U87 glioma cells in glutamine deprivation condition [PDF]

The Ukrainian Biochemical Journal, 2016
We have studied gene expression of insulin-like growth factor binding proteins in U87 glioma cells upon glutamine deprivation depending on the inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress.
O. H. Minchenko, A. P. Kharkova, D. O. Minchenko, L. L. Karbovskyi   +3 more
doaj   +1 more source

Inhibition of IRE1 modifies effect of glucose deprivation on the expression of TNFα-related genes in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2015
Inhibition of IRE1 (inositol requiring enzyme-1), the major signaling pathway of endoplasmic reticulum stress, significantly decreases glioma cell proliferation and tumor growth.
I. V. Kryvdiuk, D. O. Minchenko, N. A. Hlushchak, O. O. Ratushna, L. L. Karbovskyi, O. H. Minchenko   +5 more
doaj   +1 more source