Hypoxic regulation of MYBL1, MEST, TCF3, TCF8, GTF2B, GTF2F2 and SNAI2 genes expression in U87 glioma cells upon IRE1 inhibition [PDF]
The Ukrainian Biochemical Journal, 2016 We investigated the impact of IRE1/ERN1 (inositol requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) knockdown on hypoxic regulation of the expression of a subset of proliferation and migration-related genes in U87 glioma cells.
O. H. Minchenko +3 more
doaj +4 more sources
Inhibition of IRE1 modifies the hypoxic regulation of GADD family gene expressions in U87 glioma cells [PDF]
The Ukrainian Biochemical Journal, 2016 We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNA damage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), which controls cell proliferation and tumor ...
O. H. Minchenko +5 more
doaj +3 more sources
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD [PDF]
Cell Reports, 2014 An evolutionarily conserved unfolded protein response (UPR) component, IRE1, cleaves XBP1/HAC1 introns in order to generate spliced mRNAs that are translated into potent transcription factors.
Arvin B. Tam +2 more
doaj +2 more sources
IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells
Biomolecules, 2020 While the role of hypoxia and the induction of the hypoxia inducible factors (HIFs) and the unfolded protein response (UPR) pathways in the cancer microenvironment are well characterized, their roles and relationship in normal human endothelium are less ...
Adrianna Moszyńska +2 more
doaj +2 more sources
Hypoxic regulation of the expression of cell proliferation related genes in U87 glioma cells upon inhibition of IRE1 signaling enzyme [PDF]
The Ukrainian Biochemical Journal, 2017 We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and a controller of cell proliferation and tumor growth, on hypoxic regulation of the expression of different ...
O. H. Minchenko +5 more
doaj +3 more sources
IRE1 RNase controls CD95-mediated cell death
EMBO ReportsSignalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of the DR CD95/Fas, and its cell ...
Diana Pelizzari-Raymundo +11 more
doaj +2 more sources
Ire1 inhibitors attenuate Candida albicans pathogenicity and demonstrate potential for application in antifungal therapy [PDF]
Frontiers in MicrobiologyIntroductionCandida albicans is a common opportunistic pathogen responsible for both superficial and invasive infections. The unfolded protein response, triggered by endoplasmic reticulum stress, plays a crucial role in its survival and pathogenicity ...
Hua Wang +8 more
doaj +2 more sources
Dual IRE1 targets: Determinants of the cell fate? [PDF]
FEBS JInternational audienceIRE1α (hereafter referred to as IRE1) is one of the sensors implicated in the unfolded protein response that controls the ER protein homeostasis (also known as proteostasis).
Billat E, Legrand L, Avril T, Lafont E.
europepmc +2 more sources
Diverse Sphingolipid Species Harbor Different Effects on Ire1 Clustering [PDF]
, 2022 Endoplasmic reticulum (ER) function is dedicated to multiple essential processes in eukaryotes, including the processing of secretory proteins and the biogenesis of most membrane lipids.
Robert F. L. Steuart (23534725) +5 more
core +2 more sources
P11.61 Development of a novel preclinical GBM model and therapeutic impact of IRE1 inhibition [PDF]
Neuro Oncol, 2019 International audienceGlioblastoma Multiforme (GBM) is the most severe primary brain tumor and represents more than 15% of all brain tumors. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient’s survival post ...
Le Reste P +9 more
europepmc +2 more sources