Results 31 to 40 of about 996,321 (170)

ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response

Journal of Lipid Research, 2022
The unfolded protein response (UPR) is an elaborate signaling network that evolved to maintain proteostasis in the endoplasmic reticulum (ER) and mitochondria (mt).
Asli D. Yildirim, Mevlut Citir, Asli E. Dogan, Zehra Veli, Zehra Yildirim, Ozlem Tufanli, Alexis Traynor-Kaplan, Carsten Schultz, Ebru Erbay   +8 more
doaj   +1 more source

Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2016
We have studied the effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells under the inhibition of IRE1 (inositol requiring enzyme-1), which controls cell proliferation and tumor growth as a central ...
O. H. Minchenko, О. O. Riabovol, D. O. Tsymbal, D. O. Minchenko, О. O. Ratushna   +4 more
doaj   +1 more source

IRE1 KNOCKDOWN MODIFIES GLUCOSE AND GLUTAMINE DEPRIVATION EFFECTS ON THE EXPRESSION OF PROLIFERATION RELATED GENES IN U87 GLIOMA CELLS [PDF]

Biotechnologia Acta, 2016
We have studied the expression of genes encoding proliferation related factors and enzymes such as IL13RA2, KRT18, CD24, ING1, ING2, MYL9, BET1, TRAPPC3, ENDOG, POLG, TSFM, and MTIF2 in U87 glioma cells upon glucose and glutamine deprivation in relation ...
D. O. Tsymbal, D. O. Minchenko, O. O. Riabovol, O. O. Ratushna, O. H. Minchenko   +4 more
doaj   +1 more source

Structure-Based Drug Discovery of IRE1 Modulators

, 2022
International audienceIRE1α (inositol-requiring enzyme 1 alpha, referred to IRE1 hereafter) is an Endoplasmic Reticulum (ER) resident transmembrane enzyme with cytosolic kinase/RNAse activities.
Xavier Guillory, Eriksson, Leif A,, Pelizzari Raymundo, D., Guillory, X., Leif A. Eriksson, Pelizzari Raymundo, Diana, Diana Pelizzari Raymundo, Eric Chevet, Chevet, Eric, Guillory, Xavier, Chevet, E., Eriksson, Leif A   +11 more
core   +1 more source

IRE1 KNOCKDOWN MODIFIES THE GLUTAMINE AND GLUCOSE DEPRIVATION EFFECT ON THE EXPRESSION OF NUCLEAR GENES ENCODING MITOCHONDRIAL PROTEINS IN U87 GLIOMA CELLS [PDF]

Biotechnologia Acta, 2016
We have studied the glucose and glutamine deprivation effect on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. O. , D. O. , D. O. , O.O. , O. H.
doaj   +1 more source

Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach [PDF]

, 2019
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
Carlesso, Antonio
core   +1 more source

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

, 2012
Free to read at publisher's site.\ud \ud IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated degradation of diverse membrane-bound mRNAs ...
Ron, David, Sadowski, Pawel G., Silverman, Robert H., Goodman, JM, Ron, D, Cross, BCS, Baxendale, Ian R., Zak, Jaroslav, Harding, HP, Jha, Babal Kant, Zak, J, Bond, Peter J., Jha, BK, Goodman, Jonathan M., Neubert, TA, Silverman, RH, Neubert, Thomas A., Baxendale, IR, Sadowski, PG, Cross, Benedict C. S., Bond, PJ, Harding, Heather P.   +21 more
core   +1 more source

IRE1 signaling exacerbates Alzheimer's disease pathogenesis [PDF]

, 2017
Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation.
Claudia Salazar, Claudio Soto, Scheper, Wiep; id_orcid, Danilo B. Medinas, Andrew Foley, Ardiles, Álvaro O, Espinoza, Sandra, Peter Thielen, Foley, Andrew, Durán Aniotz, Claudia, Victor Hugo Cornejo, Sandra Espinoza, Iwawaki, Takao, Hoozemans, Jeroen J M, Takao Iwawaki, Jeroen J. M. Hoozemans, Hetz Flores, Claudio, Duran-Aniotz, Claudia, Soto, Claudio, Gajardo, Ivana, Ivana Gajardo, Hetz, Claudio, Medinas, Danilo B, Ardiles, Alvaro O., Thielen, Peter, Adrian G. Palacios, Medinas Bilches, Danilo, Palacios, Adrian G., Salazar, Claudia, Hoozemans, Jeroen J. M., Claudio Hetz, Cornejo, Victor Hugo, Álvaro O. Ardiles, Wiep Scheper, Claudia Duran-Aniotz, Scheper, Wiep, Palacios, Adrian G   +36 more
core   +1 more source

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

Cells, 2020
Glioblastoma (GBM) is the most prevalent malignant primary brain tumor with a very poor survival rate. Temozolomide (TMZ) is the common chemotherapeutic agent used for GBM treatment. We recently demonstrated that simvastatin (Simva) increases TMZ-induced
Sanaz Dastghaib, Shahla Shojaei, Zohreh Mostafavi-Pour, Pawan Sharma, John B. Patterson, Afshin Samali, Pooneh Mokarram, Saeid Ghavami   +7 more
doaj   +1 more source

Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response. [PDF]

PLoS ONE, 2013
Cadmium (Cd) causes generation of reactive oxygen species (ROS) that trigger renal tubular injury. We found that rapamycin, an inhibitor of mTORC1, attenuated Cd-induced apoptosis in renal tubular cells.
Hironori Kato, Ryohei Katoh, Masanori Kitamura   +2 more
doaj   +1 more source