Results 21 to 30 of about 996,321 (170)

A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice. [PDF]

, 2023
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated upon endoplasmic reticulum (ER) stress.
Xavier, Guillory, Luc, Negroni, Eric, Chevet, Dimitrios, Doultsinos, Leif A., Eriksson, Raphael, Pineau, Elena, Gkotsi, Aristotelis, Chatziioannou, Thodoris, Koutsandreas, Tony, Avril, Antonio, Carlesso, Diana, Pelizzari-Raymundo, Chloé, Sauzay   +12 more
core   +2 more sources

Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

Frontiers in Pharmacology, 2022
Backgroud: Ferroptosis is a form of regulated cell death in ischemia-reperfusion (I/R) injury models. Acute kidney injury (AKI) induced by I/R injury can result in cell death, and subcellular structural changes, including expansion of the endoplasmic ...
Yan Liang, Yan Liang, Yan Liang, Zhenjie Liu, Zhenjie Liu, Lingyun Qu, Lingyun Qu, Yingzi Wang, Yali Zhou, Lulu Liang, Lulu Liang, Lulu Liang, Yanhong Guo, Lin Tang, Lin Tang   +14 more
doaj   +1 more source

Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression

EMBO Molecular Medicine, 2022
Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs.
Zehra Yildirim, Sabyasachi Baboo, Syed M Hamid, Asli E Dogan, Ozlem Tufanli, Sabrina Robichaud, Christina Emerton, Jolene K Diedrich, Hasan Vatandaslar, Fotis Nikolos, Yanghong Gu, Takao Iwawaki, Elizabeth Tarling, Mireille Ouimet, David L Nelson, John R Yates, Peter Walter, Ebru Erbay   +17 more
doaj   +1 more source

Effect of hypoxia on the expression of genes that encode some IGFBP and CCN proteins in U87 glioma cells depends on IRE1 signaling [PDF]

The Ukrainian Biochemical Journal, 2015
We have studied hypoxic regulation of the expression of different insulin-like growth factor binding­ protein genes in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress ...
O. H. Minchenko, A. P. Kharkova, D. O. Minchenko, L. L. Karbovskyi   +3 more
doaj   +1 more source

Inhibition of IRE1 modifies hypoxic regulation of G6PD, GPI, TKT, TALDO1, PGLS and RPIA genes expression in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2017
We have studied the effect of hypoxia on the expression level of mRNA of the basic enzymes of pentose-phosphate cycle (G6PD, TKT, TALDO1, PGLS and RPIA) and glucose-6-phosphate isomerase (GPI) in U87 glioma cells in relation to inhibition of IRE1 ...
O. H. Minchenko, I. A. Garmash, D. O. Minchenko, A. Y. Kuznetsova, O. O. Ratushna   +4 more
doaj   +1 more source

Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 Infection

Viruses, 2020
Bovine herpesvirus 1 (BoHV-1) is an alphaherpesvirus that causes great economic losses in the cattle industry. Herpesvirus infection generally induces endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in infected cells.
Song Wang, Xiaomei Ma, Hongmei Wang, Hongbin He   +3 more
doaj   +1 more source

OVEREXPRESSION OF DOMINANT-NEGATIVE IRE1 ENZYME IN H1299-shE6AP CELLS INCREASES HEAT SHOCK ELEMENT-DEPENDENT TRANSCRIPTION [PDF]

Biotechnologia Acta, 2015
To investigate IRE1-dependent branch of endoplasmic reticulum stress pathway in various cancer cells we created cDNA-constructs for expression of dominant-negative inositol-requiring enzyme – 1 IRE1 and cytosolic domain of IRE1 fused on a C-terminus with
D. O. , О. H.
doaj   +1 more source

Distinct roles of the IRE1α arm and PERK arm of unfolded protein response in arachidonic acid-induced ferroptosis in hepatocytes

Food Innovation and Advances, 2023
Ferroptosis is a distinct form of cell death that is driven by iron-dependent phospholipid peroxidation. Polyunsaturated fatty acids (PUFAs), particularly arachidonic acid (AA) and adrenal acid (AdA), are most prone to lipid peroxidation, which induces ...
Han Zhang, Kai Han, Shutao Yin, Lihong Fan, Hongbo Hu, Chong Zhao   +5 more
doaj   +1 more source

The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs

iScience, 2020
Summary: Dysregulation of inositol-requiring enzyme 1 (IRE1), the primary transducer of Unfolded Protein Response (UPR), has been observed in tumor initiation and progression, but the underlying mechanism remains to be further elucidated.
Kezhong Zhang, Hui Liu, Zhenfeng Song, Yuanyuan Jiang, Hyunbae Kim, Lobelia Samavati, Hien M. Nguyen, Zeng-Quan Yang   +7 more
doaj   +1 more source

Human cDC1s display constitutive activation of the UPR sensor IRE1 [PDF]

, 2022
The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune‐related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein ...
Osorio, Fabiola, Gutiérrez, Diane, Mauro Parra‐Cordero, Dominique Fernández, Osorio Olivares, Fabiola, Fabiola Osorio, Gutiérrez Cabrera, Diane, García González, Paulina, García‐González, Paulina, Parra‐Cordero, Mauro, Paulina García‐González, Fernández, Dominique, Parra Cordero, Mauro, Diane Gutiérrez   +13 more
core   +1 more source