Results 41 to 50 of about 996,321 (170)
The role of the TNF receptors and apoptosis inducing ligands in tumor growth [PDF]
The Ukrainian Biochemical Journal, 2016 Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth.
O. H. Minchenko1 +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
EXPRESSION OF UBIQUITIN SPECIFIC PEPTIDASE GENES IN IRE1 KNOCKDOWN U87 GLIOMA CELLS UPON GLUCOSE DEPRIVATION [PDF]
Biotechnologia Acta, 2016 We have studied the effect of glucose deprivation on the expression of genes encoding for ubiquitin specific peptidases — USP and autophagy related 7 ATG7 in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. H. Minchenko +5 more
doaj +1 more source
Advanced Science, EarlyView.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source
IRE1 functions and inhibition by M50 and UL50.
, 2013 Accumulation of unfolded proteins in the ER leads to recruitment of chaperones such as BiP and activation of ER stress sensors such as IRE1. (A) IRE1 dimerizes, autophosphorylates itself, and activates an endoribonuclease activity, which mediates Xbp1 ...
Julia M. Burkhart (443213) +9 more
core +1 more source
Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. [PDF]
PLoS Pathogens, 2012 Ubiquitin (Ub) is a vital regulatory component in various cellular processes, including cellular responses to viral infection. As obligate intracellular pathogens, viruses have the capacity to manipulate the ubiquitin (Ub) cycle to their advantage by ...
Jeffrey W Perry +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression.
Zihao Li +6 more
doaj +1 more source
Advanced Science, EarlyView.Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng +19 more
wiley +1 more source
Lipotoksik stres yanıtında IRE1'in yeni substratinin tanımlanması
, 2022 Cataloged from PDF version of article.Includes bibliographical references (leaves 98-107).Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is a ribonucleic acid (RNA)-binding protein (RBP ...
Yıldırım, Zehra
core
PLoS BiologyEndoplasmic-reticulum resident inositol-requiring enzyme 1α (IRE1) supports protein homeostasis via its cytoplasmic kinase-RNase module. Known cancer dependency on IRE1 entails its enzymatic activation of the transcription factor XBP1s and of regulated ...
Iratxe Zuazo-Gaztelu +20 more
doaj +1 more source