Oleanolic acid suppresses migration and invasion of malignant glioma cells by inactivating MAPK/ERK signaling pathway. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases/Extracellular signal-regulated kinase (MAPK/ERK) pathway is essential for migration and invasion of malignant glioma. It is efficient to inhibit migration and invasion of glioma cells by targeting this pathway. Oleanolic
Guocai Guo +3 more
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Ferroptosis inhibits biological behaviors of glioma cells by downregulating Galectin-9 transcriptional level via extracellular Acetyl-HMGB1 [PDF]
Scientific ReportsFerroptosis, the most common programmed cell death process, and immune checkpoints play increasingly prominent roles in glioma. However, the effects of ferroptosis on immune checkpoints on glioma remain unclear.
Yechi Xu, Guofeng Tan, Rusen Zhu
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Investigation of adhesion and mechanical properties of human glioma cells by single cell force spectroscopy and atomic force microscopy. [PDF]
PLoS ONE, 2014 Active cell migration and invasion is a peculiar feature of glioma that makes this tumor able to rapidly infiltrate into the surrounding brain tissue. In our recent work, we identified a novel class of glioma-associated-stem cells (defined as GASC for ...
Laura Andolfi +9 more
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The Role of Myeloid Cells in GBM Immunosuppression
Frontiers in Immunology, 2022 Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the most aggressive glioma type and resistant to immunotherapy, mainly due to its unique immune environment.
Ya-Jui Lin +5 more
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Pathophysiological roles of integrins in gliomas from the perspective of glioma stem cells
Frontiers in Cell and Developmental Biology, 2022 Glioblastoma is the most common primary intracranial tumor and is also one of the most malignant central nervous system tumors. Its characteristics, such as high malignancy, abundant tumor vasculature, drug resistance, and recurrence-prone nature, cause ...
Maoyu Wang +3 more
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Di-san junyi daxue xuebao, 2020 Objective To investigate the effect of exosomes secreted by hypoxia-exposed glioma cells on the migration ability of glioma stem cells in vitro.
CHENG Yue, YE Xiufeng
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Stem Cell Research & Therapy, 2021 Background The tumour microenvironment contributes to chemotherapy resistance in gliomas, and glioma-associated mesenchymal stromal/stem cells (gaMSCs) are important stromal cell components that play multiple roles in tumour progression. However, whether
Bing-zhou Xue +13 more
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Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles
Cell Reports, 2020 Summary: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors ...
Xiaofei Gao +20 more
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Fluorescence imaging analysis of the glioma microenvironment
Journal of Innovative Optical Health Sciences, 2023 Glioma is the most malignant brain cancer. The neurons, macrophages, T cells and other immune cells constitute the glioma immunosuppressive microenvironment.
Xuwen Peng +3 more
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Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. [PDF]
PLoS ONE, 2008 While neurosphere- as well as xenograft tumor-initiating cells have been identified in gliomas, the resemblance between glioma cells and neural stem/progenitor cells as well as the prognostic value of stem/progenitor cell marker expression in glioma are ...
Johan Rebetz +7 more
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