Circulating Tumor Cells for Glioma [PDF]
Frontiers in Oncology, 2021 Liquid biopsy has entered clinical applications for several cancers, including metastatic breast, prostate, and colorectal cancer for CTC enumeration and NSCLC for EGFR mutations in ctDNA, and has improved the individualized treatment of many cancers, but relatively little progress has been made in validating circulating biomarkers for brain ...
Huikai Zhang +4 more
openaire +3 more sources
Multiscale rheology of glioma cells [PDF]
Biomaterials, 2021 Cells tend to soften during cancer progression, suggesting that mechanical phenotyping could be used as a diagnostic or prognostic method. Here we investigate the cell mechanics of gliomas, brain tumors that originate from glial cells or glial progenitors.
Alibert, Charlotte +6 more
openaire +2 more sources
Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles
Cell Reports, 2020 Summary: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors ...
Xiaofei Gao +20 more
doaj +1 more source
Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]
, 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher +3 more
core +3 more sources
KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment [PDF]
, 2016 Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent ...
Catalano, Myriam +13 more
core +3 more sources
Glioma-derived ADAM10 induces regulatory B cells to suppress CD8+ T cells. [PDF]
PLoS ONE, 2014 CD8+ T cells play an important role in the anti-tumor activities of the body. The dysfunction of CD8+ T cells in glioma is unclear. This study aims to elucidate the glioma cell-derived ADAM10 (A Disintegrin and metalloproteinase domain-containing protein
Zhuo-peng Ye +6 more
doaj +1 more source
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]
, 2016 Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M +11 more
core +2 more sources
The role of glioma stem cells in glioma tumorigenesis
Frontiers in Bioscience, 2014 Malignant gliomas, the most common type of primary brain tumor, account for 80% of malignant tumors in the central nervous system (CNS). There are three principal types of glioma: astrocytomas, oligodendrogliomas, and oligoastrocytomas. Glioma stem cells (GSCs) have been found in all types; however, many fundamental questions about GSCs remain ...
Chang-lin, Yin +3 more
openaire +2 more sources
Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature [PDF]
, 2017 The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression ...
Bush, Erin C +6 more
core +2 more sources
Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. [PDF]
PLoS ONE, 2008 While neurosphere- as well as xenograft tumor-initiating cells have been identified in gliomas, the resemblance between glioma cells and neural stem/progenitor cells as well as the prognostic value of stem/progenitor cell marker expression in glioma are ...
Johan Rebetz +7 more
doaj +1 more source