Results 41 to 50 of about 265,026 (309)

Glioma cells on the run – the migratory transcriptome of 10 human glioma cell lines [PDF]

BMC Genomics, 2008
Abstract Background Glioblastoma multiforme (GBM) is the most common primary intracranial tumor and despite recent advances in treatment regimens, prognosis for affected patients remains poor. Active cell migration and invasion of GBM cells ultimately lead to ubiquitous tumor recurrence and patient death ...
Holz David, McDonough Wendy S, Henrichs Amanda N, Anderson Eric M, Nakada Satoko, Beaudry Christian, Nakada Mitsutoshi, Reavie Linsey B, Hoelzinger Dominique B, Rennert Jessica L, Demuth Tim, Joy Anna, Lin Richard, Pan Kuang H, Lih Chih J, Cohen Stan N, Berens Michael E   +16 more
openaire   +3 more sources

Tumor Microenvironment in Glioma Invasion

Brain Sciences, 2022
A major malignant trait of gliomas is their remarkable infiltration capacity. When glioma develops, the tumor cells have already reached the distant part. Therefore, complete removal of the glioma is impossible.
Sho Tamai, Toshiya Ichinose, Taishi Tsutsui, Shingo Tanaka, Farida Garaeva, Hemragul Sabit, Mitsutoshi Nakada   +6 more
doaj   +1 more source

Environmental stimuli shape microglial plasticity in glioma [PDF]

, 2017
In glioma, microglia and infiltrating macrophages are exposed to factors that force them to produce cytokines and chemokines, contributing to tumor growth and maintaining a pro-tumorigenic, immunosuppressed microenvironment.
Alboni, Armaiz-Pena, Bisht, Branchi, Butovsky, Cao, Chabry, Coniglio, Coughlin, Duluc, Dunn, Ehninger, Ehninger, Gabrusiewicz, Garofalo, Goldszmid, Graeber, Guillerey, Hambardzumyan, Haynes, Jung, Kaplan, Kmiecik, Kmiecik, Koka, Lauro, Mantovani, Markovic, Markovic, Mathios, Mieczkowski, Morrison, Murray, Nachat-Kappes, Nguyen, Ohsawa, Pagani, Parker, Pyonteck, Quail, Rattazzi, Richter, Rodríguez, Sale, Schmittgen, Sica, Sierra, Song, Stabile, Strengell, Szulzewsky, Szulzewsky, Tremblay, Tremblay, Van Rooijen, Vivier, Waldmann, Westwood, Yu, Zhu   +59 more
core   +2 more sources

Glioma Stemlike Cells Enhance the Killing of Glioma Differentiated Cells by Cytotoxic Lymphocytes

PLOS ONE, 2016
Glioblastoma multiforme, the most aggressive primary brain tumor, is maintained by a subpopulation of glioma cells with self-renewal properties that are able to recapitulate the entire tumor even after surgical resection or chemo-radiotherapy. This typifies the vast heterogeneity of this tumor with the two extremes represented on one end by the glioma ...
Bassoy, Esen Yonca, Chiusolo, Valentina, Jacquemin, Guillaume, Riccadonna, Cristina, Walker, Paul R., Martinvalet, Denis   +5 more
openaire   +6 more sources

Co-culture models for investigating cellular crosstalk in the glioma microenvironment

Cancer Pathogenesis and Therapy
Glioma is the most prevalent primary malignant tumor in the central nervous system (CNS). It represents a diverse group of brain malignancies characterized by the presence of various cancer cell types as well as an array of noncancerous cells, which ...
Xiaodong Niu, Yan Zhang, Yuan Wang
doaj   +1 more source

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]

, 2014
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Alonso, Daniel Fernando, Cardama, Georgina Alexandra, Ciarlantini, Matias Sebastián, Comin, Maria Julieta, Gandolfi Donadío, Lucía, Gomez, Daniel Eduardo, González, Nazareno, Lorenzano Menna, Pablo   +7 more
core   +2 more sources

Promotive effects of capillary morphogenetic protein 2 on glioma cell invasion and the molecular mechanism

Folia Neuropathologica, 2019
We aimed to explore the role of capillary morphogenetic protein 2 (CMG2) in glioma cell invasion and the possible molecular mechanism. Glioma cells U87 and U251 stably overexpressing CMG2 were constructed by lentiviral transfection.
Yifan Xu, Yuxin He, Wu Xu, Tianyu Lu, Weibang Liang, Wei Jin   +5 more
doaj   +1 more source

Impact of Human Immunodeficiency Virus in the Pathogenesis and Outcome of Patients with Glioblastoma Multiforme. [PDF]

, 2016
BackgroundImprovement in antiviral therapies have been accompanied by an increased frequency of non-Acquired Immune Deficiency Syndrome (AIDS) defining malignancies, such as glioblastoma multiforme.
Bui, Timothy T, Choy, Winward, Lagman, Carlito, Lee, Seung J, Safaee, Michael, Yang, Isaac   +5 more
core   +1 more source

Osmosignalling in C6 glioma cells

FEBS Letters, 1997
The influence of aniso‐osmolarity on the activity of the MAP kinases Erk‐1 and Erk‐2 was studied in C6 glioma cells. Hypo‐osmotic treatment (205 mosmol/l) led to an increased activity of Erk‐1 and Erk‐2 within 3 min, which became maximal at 10 min and returned to basal level within 120 min.
Sinning, Ralf, Schliess, Freimut, Kubitz, Ralf, Häussinger, Dieter   +3 more
openaire   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source