Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin b1 receptor agonist in a glioma rat model [PDF]
, 2012 Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of ...
Neugebauer Witold +47 more
core +2 more sources
MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation
Cellular Physiology and Biochemistry, 2018 Background/Aims: Glioma causes significant human mortalities annually. Molecularly-targeted therapy is a focus of glioma research. Methods: Grb2-associated binding 1 (Gab1) expression and microRNA-29a-3p (“miR-29a-3p”) expression in human glioma cells ...
Nai-yuan Shao +7 more
doaj +1 more source
Hypoxia helps glioma to fight therapy [PDF]
, 2009 Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena +1 more
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Drug Design, Development and Therapy, 2022 Peizhang Wu,1,2 Jun Guo,2 Hongwei Yang,2 Debin Yuan,2 Chaoxiang Wang,2 Zhong Wang1 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China; 2Department of Neurosurgery, Yancheng First ...
Wu P +5 more
doaj
PUMA mediated afatinib-induced apoptosis in glioma cells
, 2021 Introduction Afatinib exhibits a tumor-inhibiting effect in different cancers by inducing apoptosis; however, its pro-apoptosis role in glioma cells is still not fully understood. Material and methods In the current study, two glioma cell lines (U373-MG
Xinyue Sun +3 more
core +1 more source
DUSP10 upregulation is a poor prognosticator and promotes cell proliferation and migration in glioma
Frontiers in Oncology, 2023 Dual-specificity phosphatase 10 (DUSP10) correlates with inflammation, cytokine secretion, cell proliferation, survival, and apoptosis. However, its role in glioma is unclear.
Fang Zhou +17 more
doaj +1 more source
Expression of RECK in endothelial cells of glioma: comparison with CD34 and VEGF expressions [PDF]
, 2012 Angiogenesis is thought to be involved in the progression of glioma grades, and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) has been said to be involved in maturation of vessels.
Rahmah, Nunung Nur +3 more
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YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]
, 2013 Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Mittelbronn, Michel Guy André +19 more
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Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy [PDF]
, 2009 Background: Glioblastoma is the most frequent and most malignant primary brain tumor with a poor prognosis. The translation of therapeutic strategies for glioblastoma from the experimental phase into the clinic has been limited by insufficient animal ...
Oleg Tsinkalovsky +23 more
core +2 more sources
Drug Delivery, 2018 Development of safe, efficient nanocomplex for targeted imaging and therapy of cancer stem cells in brain glioma has become a great challenge. Herein, a low-density lipoprotein receptor-related protein and a RNA aptamer bound CD133 were used as dual ...
Xiyang Sun +7 more
doaj +1 more source