Results 1 to 10 of about 1,657 (154)

ERN1 KNOCKDOWN AFFECTS THE EXPRESSION OF PDHA1, PDHB, PDHX, DLD, AND DLAT GENES AND MODIFIES THEIR HYPOXIC REGULATION [PDF]

Biotechnologia Acta
Hypoxia and endoplasmic reticulum stress are critical factors affecting tumor growth. Inhibition of ERN1 protein has the ability to suppress glioma cell proliferation and growth. Pyruvate dehydrogenase complex is a important factor for glioma cell growth
Y.P. KHIKHLO, O.V. HALKIN, Y.M. VILETSKA, O.H. MINCHENKO   +3 more
exaly   +5 more sources

GLUTAMINE DEPRIVATION AFFECTS THE EXPRESSION OF GENES WHICH CONTROL PYRUVATE DEHYDROGENASE ACTIVITY: THE IMPACT OF ERN1 KNOCKDOWN [PDF]

Biotechnologia Acta, 2022
The aim of the current investigation was to study the expression of genes encoded pyruvate dehydrogenase subunits (PDHA1, PDHB, PDHX, DLAT, and DLD) in U87 glioma cells in response to glutamine deprivation in U87 glioma cells in relation to knockdown of ...
M. Sliusar, H. Shatokhina, A. Cherednychenko, O. Minchenko   +3 more
exaly   +3 more sources

ERN1 knockdown modifies the hypoxic regulation of TP53, MDM2, USP7 and PERP gene expressions in U87 glioma cells [PDF]

Ukrainian Biochemical Journal, 2014
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly ...
S. V. Danilovskyi, D. O. Minchenko,, О. S. Moliavko, O. V. Kovalevska, L. L. Karbovskyi, O. H. Minchenko   +5 more
exaly   +4 more sources

Endoplasmic Reticulum Stress and Unfolded Protein Response Sensor ERN1 Regulates Organic Dust Induction of Lung Inflammation [PDF]

FASEB BioAdvances
Inhalation of organic dust increases the risk for respiratory symptoms and respiratory diseases, with chronic inflammation playing a major role in their development.
Shilpa Kusampudi, Velmurugan Meganathan, Vijay Boggaram   +2 more
doaj   +3 more sources

Effect of hypoxia on the expression of CCN2, PLAU, PLAUR, SLURP1, PLAT and ITGB1 genes in ERN1 knockdown U87 glioma cells [PDF]

Ukrainian Biochemical Journal, 2014
The endoplasmic reticulum stress is an important factor of tumor growth and is induced in cancer cells. We have studied the effect of ERN1 knockdown as well as hypoxia on the expression of genes encoding­ factors, which control cell proliferation, in U87
O. H. Minchenko, A. P. Kharkova, K. I. Kubaichuk, D. O. Minchenko, N. A. Hlushchak, O. V. Kovalevska   +5 more
exaly   +4 more sources

Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress [PDF]

Ukrainian Biochemical Journal, 2014
Activation of pentose phosphate pathway is an important factor of enhanced cell proliferation and tumor growth. Phosphoribosyl pyrophosphate synthetase (PRPS) is a key enzyme of this pathway and plays a central role in the synthesis of purines and ...
O. H. Minchenko, I. A. Garmash, O. V. Kovalevska, D. O. Tsymbal, D. O. Minchenko   +4 more
exaly   +4 more sources

The impact of glutamine deprivation on the expression of MEIS3, SPAG4, LHX1, LHX2, and LHX6 genes in ERN1 knockdown U87 glioma cells [PDF]

Endocrine Regulations, 2022
Objective. The aim of the current study was to investigate the expression of genes encoded homeobox proteins such as MEIS3 (Meis homeobox 3), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1), LHX2, and LHX6 in U87 glioma cells in response to ...
Krasnytska Dariia A., Khita Olena O., Tsymbal Dariia O., Luzina Olha Y., Cherednychenko Anastasiia A., Kozynkevich Halyna E., Bezrodny Borys H., Minchenko Dmytro O.   +7 more
doaj   +3 more sources

ERN1 knockdown modifies the impact of glucose and glutamine deprivations on the expression of EDN1 and its receptors in glioma cells [PDF]

Endocrine Regulations, 2021
Objective. The aim of the present investigation was to study the impact of glucose and gluta-mine deprivations on the expression of genes encoding EDN1 (endothelin-1), its cognate receptors (EDNRA and EDNRB), and ECE1 (endothelin converting enzyme 1) in ...
Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Sliusar Myroslava Y., Yefimova Yuliia V., Levadna Liudmyla O., Krasnytska Dariia A., Minchenko Oleksandr H.   +8 more
doaj   +3 more sources

ERN1 knockdown modifies the effect of glucose deprivation on homeobox gene expressions in U87 glioma cells

Endocrine Regulations, 2020
Objective. The aim of the present investigation was to study the expression of genes encoding homeobox proteins ZEB2 (zinc finger E-box binding homeobox 2), TGIF1 (TGFB induced factor homeobox 1), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1),
Tsymbal Dariia O., Minchenko Dmytro O., Khita Olena O., Rudnytska Olha V., Viletska Yulia M., Lahanovska Yulia O., He Qiuxia, Liu Kechun, Minchenko Oleksandr H.   +8 more
doaj   +3 more sources

Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells [PDF]

Endocrine Regulations, 2019
Objective. The aim of the present investigation was to study the effect of hypoxia on the expression of genes encoding endothelin-1 (EDN1) and its cognate receptors (EDNRA and EDNRB) as well as endothelin converting enzyme 1 (ECE1) in U87 glioma cells in
Minchenko Dmytro O., Tsymbal Daria O., Riabovol Olena O., Viletska Yuliia M., Lahanovska Yuliia O., Sliusar Myroslava Y., Bezrodnyi Borys H., Minchenko Oleksandr H.   +7 more
doaj   +3 more sources