Results 1 to 10 of about 1,122 (97)

GLUTAMINE DEPRIVATION AFFECTS THE EXPRESSION OF GENES WHICH CONTROL PYRUVATE DEHYDROGENASE ACTIVITY: THE IMPACT OF ERN1 KNOCKDOWN [PDF]

Biotechnologia Acta, 2022
The aim of the current investigation was to study the expression of genes encoded pyruvate dehydrogenase subunits (PDHA1, PDHB, PDHX, DLAT, and DLD) in U87 glioma cells in response to glutamine deprivation in U87 glioma cells in relation to knockdown of ...
M. Sliusar, H. Shatokhina, A. Cherednychenko, O. Minchenko   +3 more
exaly   +2 more sources

ERN1 knockdown modifies the hypoxic regulation of TP53, MDM2, USP7 and PERP gene expressions in U87 glioma cells [PDF]

Ukrainian Biochemical Journal, 2014
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly ...
S. V. Danilovskyi, D. O. Minchenko,, О. S. Moliavko, O. V. Kovalevska, L. L. Karbovskyi, O. H. Minchenko   +5 more
exaly   +2 more sources

Endoplasmic Reticulum Stress and Unfolded Protein Response Sensor ERN1 Regulates Organic Dust Induction of Lung Inflammation [PDF]

FASEB BioAdvances
Inhalation of organic dust increases the risk for respiratory symptoms and respiratory diseases, with chronic inflammation playing a major role in their development.
Shilpa Kusampudi, Velmurugan Meganathan, Vijay Boggaram   +2 more
doaj   +2 more sources

Effect of hypoxia on the expression of CCN2, PLAU, PLAUR, SLURP1, PLAT and ITGB1 genes in ERN1 knockdown U87 glioma cells [PDF]

Ukrainian Biochemical Journal, 2014
The endoplasmic reticulum stress is an important factor of tumor growth and is induced in cancer cells. We have studied the effect of ERN1 knockdown as well as hypoxia on the expression of genes encoding­ factors, which control cell proliferation, in U87
O. H. Minchenko, A. P. Kharkova, K. I. Kubaichuk, D. O. Minchenko, N. A. Hlushchak, O. V. Kovalevska   +5 more
exaly   +2 more sources

Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress [PDF]

Ukrainian Biochemical Journal, 2014
Activation of pentose phosphate pathway is an important factor of enhanced cell proliferation and tumor growth. Phosphoribosyl pyrophosphate synthetase (PRPS) is a key enzyme of this pathway and plays a central role in the synthesis of purines and ...
O. H. Minchenko, I. A. Garmash, O. V. Kovalevska, D. O. Tsymbal, D. O. Minchenko   +4 more
exaly   +2 more sources

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma [PDF]

Advanced Science
Fatty acids (FAs) create a pro‐metastatic niche in multiple cancers, but how the tumor microenvironment (TME) counteracts FA stress remains unclear.
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
doaj   +2 more sources

IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes [PDF]

Arthritis Research & Therapy
Background Rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) exhibit chronic endoplasmic reticulum stress with activation of the IRE1/phospho‑JNK arm of the unfolded protein response; yet, they remain resistant to apoptosis. Although ferroptosis
Jiaxi Liu, Wenhui Xie, Yongping Cao, Liang Zhang, Yan Geng, Zhuoli Zhang   +5 more
doaj   +2 more sources

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson’s disease [PDF]

Cell Death and Disease
The core pathological hallmark of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc), driven by misfolding and aggregation of a-synuclein (aSyn) into Lewy bodies.
Pablo Ahumada-Montalva, Francisco Muñoz-Carvajal, Sara Bórquez-Macaya, Nohela Arévalo-Ramírez, Marisol Cisternas-Olmedo, Carolina Jerez, Valentina Urbina-Muñoz, Wileidy Gomez, Pamela J. Urrutia, Etienne C. Hirsch, Manuel Ahumada, Pablo Barrias, Camila Muñoz-Yañez, Ariel Herrera-Vásquez, Gloria Arriagada, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza, Rene L. Vidal, Diego Rojas-Rivera   +19 more
doaj   +2 more sources

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways [PDF]

Advanced Science
Multiple myeloma (MM) pathogenesis is closely associated with aberrant epigenetic regulation and resulting modifications, such as dimethylation of lysine 36 in histone H3 (H3K36me2).
Jiaxuan Xu, Xiaoqing Dong, Yue Peng, Jie Yan, Peipei Xu, Feiyu Li, Suwen Zhang, Lanxin Chen, Xingjun Meng, Kangning Wang, Mengying Xing, Wenyang Li, David C. S. Huang, Quan Zhao, Bing Chen   +14 more
doaj   +2 more sources

ERN1 KNOCKDOWN AFFECTS THE EXPRESSION OF PDHA1, PDHB, PDHX, DLD, AND DLAT GENES AND MODIFIES THEIR HYPOXIC REGULATION [PDF]

Biotechnologia Acta
Hypoxia and endoplasmic reticulum stress are critical factors affecting tumor growth. Inhibition of ERN1 protein has the ability to suppress glioma cell proliferation and growth. Pyruvate dehydrogenase complex is a important factor for glioma cell growth
Y.P. KHIKHLO, O.V. HALKIN, Y.M. VILETSKA, O.H. MINCHENKO   +3 more
exaly   +2 more sources