Results 11 to 20 of about 1,657 (154)

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways [PDF]

Advanced Science
Multiple myeloma (MM) pathogenesis is closely associated with aberrant epigenetic regulation and resulting modifications, such as dimethylation of lysine 36 in histone H3 (H3K36me2).
Jiaxuan Xu, Xiaoqing Dong, Yue Peng, Jie Yan, Peipei Xu, Feiyu Li, Suwen Zhang, Lanxin Chen, Xingjun Meng, Kangning Wang, Mengying Xing, Wenyang Li, David C. S. Huang, Quan Zhao, Bing Chen   +14 more
doaj   +3 more sources

Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation

Endocrine Regulations, 2020
Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition of ...
Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Danilovskyi Serhij V., Rudnytska Olha V., Halkin Oleh V., Kryvdiuk Iryna V., Smeshkova Maria V., Yakymchuk Mykhailo M., Bezrodnyi Borys H., Minchenko Oleksandr H.   +10 more
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Hypoxic regulation of MYBL1, MEST, TCF3, TCF8, GTF2B, GTF2F2 and SNAI2 genes expression in U87 glioma cells upon IRE1 inhibition [PDF]

The Ukrainian Biochemical Journal, 2016
We investigated the impact of IRE1/ERN1 (inositol requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) knockdown on hypoxic regulation of the expression of a subset of proliferation and migration-related genes in U87 glioma cells.
O. H. Minchenko, D. O. Tsymbal, D. O. Minchenko, O. O. Kubaychuk   +3 more
doaj   +4 more sources

Expression of hexokinase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase genes in ERN1 knockdown glioma U87 cells: effect of hypoxia and glutamine or glucose deprivation

Біологічні студії, 2011
Endoplasmic reticulum stress, as well as hypoxia and ischemia, are important factors for tumor neovascularization and growth. Cancer cells preferentially utilize glycolysis in order to satisfy their increased energetic and biosynthetic requirements. High
D. O. Minchenko, R. Y. Marunych, E. V. Khomenko, T. V. Bakalets, O. H. Minchenko   +4 more
doaj   +3 more sources

ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells

Endocrine Regulations
Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2)
Krasnytska Daria A., Khita Olena O., Viletska Yuliia M., Minchenko Dmytro O., Halkin Oleh V., Rudnytska Olha V., Hoian Sofiia L., Minchenko Oleksandr H.   +7 more
doaj   +3 more sources

Effect of hypoxia and glutamine or glucose deprivation on the expression of retinoblastoma and retinoblastoma-related genes in ERN1 knockdown glioma U87 cell line

American Journal of Molecular Biology, 2012
The expression of retinoblastoma and several retinoblastoma-related genes was studied in glioma cell line U87 and its subline with knockdown of ERN1 (endoplasmic reticulum—nuclei-1), the main endoplasmic reticulum stress sensing and signaling enzyme.
Dmytro O. Minchenko, Leonid L. Karbovskyi, Serhii V. Danilovskyi, Michel Moenner, Oleksandr H. Minchenko   +4 more
exaly   +3 more sources

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson’s disease [PDF]

Cell Death and Disease
The core pathological hallmark of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc), driven by misfolding and aggregation of a-synuclein (aSyn) into Lewy bodies.
Pablo Ahumada-Montalva, Francisco Muñoz-Carvajal, Sara Bórquez-Macaya, Nohela Arévalo-Ramírez, Marisol Cisternas-Olmedo, Carolina Jerez, Valentina Urbina-Muñoz, Wileidy Gomez, Pamela J. Urrutia, Etienne C. Hirsch, Manuel Ahumada, Pablo Barrias, Camila Muñoz-Yañez, Ariel Herrera-Vásquez, Gloria Arriagada, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza, Rene L. Vidal, Diego Rojas-Rivera   +19 more
doaj   +2 more sources

Effect of glucose deprivation on the expression of genes encoding glucocorticoid receptor and some related factors in ERN1-knockdown U87 glioma cells

Endocrine Regulations, 2019
Objective. The aim of the present study was to examine the effect of glucose deprivation on the expression of genes encoded glucocorticoid receptor (NR3C1) and some related proteins (NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3) in U87 glioma cells ...
Riabovol Olena O., Tsymbal Dariia O., Minchenko Dmytro O., Lebid-Biletska Kateryna M., Sliusar Myroslava Y., Rudnytska Olha V., Minchenko Oleksandr H.   +6 more
doaj   +3 more sources

Glucose-dependent control of insulin like growth factor 2 mRNA binding protein 2 and other gene expressions in ERN1 knockdown glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum stress and glucose supply are significant factors in glioblastoma growth. The present study aims to investigate the impact of glucose-dependent control of IGF2BP2, TOB1, HBEGF, TWIST1, CCNH, and E2F1 gene expression in ...
Minchenko Oleksandr H., Viletska Yuliia M., Sliusar Myroslava Y., Hnatiuk Oksana S., Ratushna Oksana O., Feldman Taia V., Kozynkevych Halyna E., Bezrodnyi Borys H., Minchenko Dmytro O.   +8 more
doaj   +2 more sources

THE IMPACT OF GRAPHENE OXIDE NANOPARTICLES ON THE EXPRESSION OF ENDOPLASMIC RETICULUM STRESS-DEPENDENT GENES IS MORE PRONOUNCED IN NORMAL HUMAN ASTROCYTES THAN GLIOBLASTOMA CELLS [PDF]

Biotechnologia Acta
Aim. The purpose of the study was to investigate the impact of graphene oxide nanoparticles on the expression of a subset of ER stress-dependent genes in normal human astrocytes in comparison with glioblastoma cells depending on the knockdown of ERN1.
O.V. RUDNYTSKA, Y.V. KULISH, O.O. KHITA, Y. M. VILETSKA   +3 more
doaj   +3 more sources