Results 11 to 20 of about 119,648 (139)

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

Endocrine Regulations, 2023
Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H.   +8 more
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ERN1 knockdown modifies the effect of glucose deprivation on homeobox gene expressions in U87 glioma cells

Endocrine Regulations, 2020
Objective. The aim of the present investigation was to study the expression of genes encoding homeobox proteins ZEB2 (zinc finger E-box binding homeobox 2), TGIF1 (TGFB induced factor homeobox 1), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1),
Tsymbal Dariia O., Minchenko Dmytro O., Khita Olena O., Rudnytska Olha V., Viletska Yulia M., Lahanovska Yulia O., He Qiuxia, Liu Kechun, Minchenko Oleksandr H.   +8 more
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Expression of hexokinase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase genes in ERN1 knockdown glioma U87 cells: effect of hypoxia and glutamine or glucose deprivation [PDF]

Біологічні студії, 2011
Endoplasmic reticulum stress, as well as hypoxia and ischemia, are important factors for tumor neovascularization and growth. Cancer cells preferentially utilize glycolysis in order to satisfy their increased energetic and biosynthetic requirements. High
D. O. Minchenko, R. Y. Marunych, E. V. Khomenko, T. V. Bakalets, O. H. Minchenko   +4 more
doaj   +2 more sources

ERN1 modifies the effect of glutamine deprivation on tumor growth related factors expression in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2018
The expression of a subset of genes encoding important tumor growth related factors in U87 glioma cells with ERN1 (endoplasmic reticulum to nucleus signaling 1) loss of function as well as upon glutamine deprivation was studied.
O. H. Minchenko, A. P. Kharkova, O. S. Hnatiuk, O. Y. Luzina, I. V. Kryvdiuk, A. Y. Kuznetsova   +5 more
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ERN1 dependent impact of glucose and glutamine deprivations on PBX3, PBXIP1, PAX6, MEIS1, and MEIS2 genes expression in U87 glioma cells

Endocrine Regulations, 2023
Objective. Homeobox genes play a fundamental role in the embryogenesis, but some of them have been linked to oncogenesis. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of homeobox genes such ...
Krasnytska Dariia O., Viletska Yuliia M., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Cherednychenko Anastasiia A., Kozynkevych Halyna E., Oksiom Nataliia S., Minchenko Oleksandr H.   +8 more
doaj   +2 more sources

Endoplasmic reticulum–nuclei signaling enzyme-1 knockdown modulates effect of hypoxia and ischemia on the expression of circadian genes in glioma cells [PDF]

Біологічні студії, 2011
The main molecular components of circadian clock system are proteins which play a significant role in the control of both metabolism and malignant tumor growth.
L. L. Karbovskyi, D. O. Minchenko, S. V. Danylovsky, M. Moenner, O. H. Minchenko   +4 more
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Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner

Endocrine Regulations, 2020
Objective. The aim of this investigation was to study the expression of genes encoding cAMP-activated protein kinase catalytic and regulatory A subunits (PRKACA and PRKAR1A) and related proteins such as cAMP-dependent protein kinase inhibitors A and G ...
Ratushna Oksana O.
doaj   +2 more sources

Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation

Endocrine Regulations, 2020
Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition of ...
Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Danilovskyi Serhij V., Rudnytska Olha V., Halkin Oleh V., Kryvdiuk Iryna V., Smeshkova Maria V., Yakymchuk Mykhailo M., Bezrodnyi Borys H., Minchenko Oleksandr H.   +10 more
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Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells

Endocrine Regulations, 2019
Objective. The aim of the present investigation was to study the effect of hypoxia on the expression of genes encoding endothelin-1 (EDN1) and its cognate receptors (EDNRA and EDNRB) as well as endothelin converting enzyme 1 (ECE1) in U87 glioma cells in
Minchenko Dmytro O., Tsymbal Daria O., Riabovol Olena O., Viletska Yuliia M., Lahanovska Yuliia O., Sliusar Myroslava Y., Bezrodnyi Borys H., Minchenko Oleksandr H.   +7 more
doaj   +2 more sources

The ERN1 signaling pathway of unfolded protein controls the expression of EDEM1 and its hypoxic regulation in glioblastoma cells

Endocrine Regulations
Objective. For the effective growth of malignant tumors, including glioblastoma, the necessary factors involve endoplasmic reticulum (ER) stress, hypoxia, and the availability of nutrients, particularly glucose.
Minchenko Oleksandr H., Hrebennykova Vita O., Viletska Yuliia M., Hnatiuk Oksana S., Sliusar Myroslava Y., Kozynkevych Halyna E., Minchenko Dmytro O.   +6 more
doaj   +2 more sources