Results 21 to 30 of about 119,648 (139)

Glucose-dependent control of insulin like growth factor 2 mRNA binding protein 2 and other gene expressions in ERN1 knockdown glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum stress and glucose supply are significant factors in glioblastoma growth. The present study aims to investigate the impact of glucose-dependent control of IGF2BP2, TOB1, HBEGF, TWIST1, CCNH, and E2F1 gene expression in ...
Minchenko Oleksandr H., Viletska Yuliia M., Sliusar Myroslava Y., Hnatiuk Oksana S., Ratushna Oksana O., Feldman Taia V., Kozynkevych Halyna E., Bezrodnyi Borys H., Minchenko Dmytro O.   +8 more
doaj   +2 more sources

Effect of glucose deprivation on the expression of genes encoding glucocorticoid receptor and some related factors in ERN1-knockdown U87 glioma cells

Endocrine Regulations, 2019
Objective. The aim of the present study was to examine the effect of glucose deprivation on the expression of genes encoded glucocorticoid receptor (NR3C1) and some related proteins (NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3) in U87 glioma cells ...
Riabovol Olena O., Tsymbal Dariia O., Minchenko Dmytro O., Lebid-Biletska Kateryna M., Sliusar Myroslava Y., Rudnytska Olha V., Minchenko Oleksandr H.   +6 more
doaj   +2 more sources

Fucoxanthin Ameliorates MASLD by Directly Targeting GRP78 to Restore ER Homeostasis and Activate AMPK Signaling. [PDF]

Food Sci Nutr
Proposed model of fucoxanthin in ameliorating MASLD via the GRP78‐AMPK axis. In MASLD, excessive lipid accumulation (FFA, TG, DNL) leads to ER stress activation (upregulation of CHOP, ATF6, IRE1) and GRP78 dysfunction, promoting hepatic lipid droplet (LD) formation. Fucoxanthin directly binds to GRP78, which in turn activates AMPK signaling.
Zhang L, Zhang R, Wu Y, Chen B, Wang C, Wang C, Wen Z, Zhang J, Tong H, Hong L.   +9 more
europepmc   +2 more sources

ERN1 dependent regulation of TMED10, MYL9, SPOCK1, CUL4A and CUL4B genes expression at glucose and glutamine deprivations in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2020
It was shown previously that inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) pathway, a central mediator of the unfolded protein response, leads to suppression of tumor growth through down-regulation of key pro-proliferative and up ...
O. H. Minchenko, O. S. Hnatiuk, D. O. Tsymbal, Y. M. Viletska, S. V. Danilovskyi, O. V. Halkin, I. V. Kryvdiuk, O. V. Rudnytska   +7 more
doaj   +1 more source

RBM39 modulates UPR signaling through alternative splicing of IRE1α/<i>ERN1</i>. [PDF]

Genes Dev
The unfolded protein response (UPR) preserves endoplasmic reticulum proteostasis through coordinated signaling pathways, including the IRE1α–XBP1 axis, which promotes adaptive transcriptional programs via noncanonical XBP1 mRNA ...
Kim JJ, Behera AK, Damodaran AP, Kordale S, Gonatopoulos-Pournatzis T.   +4 more
europepmc   +2 more sources

Identification of an ERN1 target site within EGFP mRNA [PDF]

, 2022
EGFP (enhanced green fluorescent protein) is one of the most common tools used in life sciences, including research focusing on proteostasis. Here we report that ERN1 (endoplasmic reticulum to nucleus signaling 1), which is upregulated by UPR (unfolded ...
Baeken, Marius W., Yokobayashi, Yohei
core   +2 more sources

Ubiquitin-Proteasome System-Related Prognostic Model and Immune Landscape in Glioblastoma. [PDF]

Int J Genomics
Background Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis. This study is aimed at establishing an ubiquitin‐proteasome system (UPS)–related prognostic model and investigating its link to immune infiltration and therapy response. Materials and Methods GBM datasets were obtained from public databases.
Huo D, Feng Y, Yu Z, Xie W, Jin H.
europepmc   +2 more sources

ERN1 dependent impact of glutamine and glucose deprivations on the pyruvate dehydrogenase genes expression in glioma cells

Endocrine Regulations, 2022
Objective. The aim of the present study was to investigate the expression of pyruvate dehydrogenase genes such as PDHA1, PDHB, DLAT, DLD, and PDHX in U87 glioma cells in response to glutamine and glucose deprivations in control glioma cells and ...
Shatokhina Hanna O., Khita Olena O., Minchenko Dmytro O., Tsymbal Dariia O., Luzina Olha R., Danilovskyi Serhiy V., Sliusar Myroslava Y., Levadna Liudmyla O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

ERN1 knockdown modifies the impact of glucose and glutamine deprivations on the expression of EDN1 and its receptors in glioma cells

Endocrine Regulations, 2021
Objective. The aim of the present investigation was to study the impact of glucose and gluta-mine deprivations on the expression of genes encoding EDN1 (endothelin-1), its cognate receptors (EDNRA and EDNRB), and ECE1 (endothelin converting enzyme 1) in ...
Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Sliusar Myroslava Y., Yefimova Yuliia V., Levadna Liudmyla O., Krasnytska Dariia A., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

The impact of glutamine deprivation on the expression of MEIS3, SPAG4, LHX1, LHX2, and LHX6 genes in ERN1 knockdown U87 glioma cells

Endocrine Regulations, 2022
Objective. The aim of the current study was to investigate the expression of genes encoded homeobox proteins such as MEIS3 (Meis homeobox 3), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1), LHX2, and LHX6 in U87 glioma cells in response to ...
Krasnytska Dariia A., Khita Olena O., Tsymbal Dariia O., Luzina Olha Y., Cherednychenko Anastasiia A., Kozynkevich Halyna E., Bezrodny Borys H., Minchenko Dmytro O.   +7 more
doaj   +1 more source