Results 1 to 10 of about 4,624,933 (258)

The adaptive transition of glioblastoma stem cells and its implications on treatments

Signal Transduction and Targeted Therapy, 2021
Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time
Zeyu Wang, Hao Zhang, Shengchao Xu, Zhixiong Liu, Quan Cheng   +4 more
doaj   +2 more sources

Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands

OncoImmunology, 2022
Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand–receptor interactions between γδ T ...
Haeyoun Choi, Yunkyung Lee, Soon A Park, Ji Hyeon Lee, Junseong Park, Jang Hyun Park, Heung Kyu Lee, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn   +9 more
doaj   +3 more sources

Pharmacological Investigation of CC-LAAO, an L-Amino Acid Oxidase from Cerastes cerastes Snake Venom

Toxins, 2021
Snake venom proteins, which are responsible for deadly snakebite envenomation, induce severe injuries including neurotoxicity, myotoxicity, cardiotoxicity, hemorrhage, and the disruption of blood homeostasis.
Zaineb Abdelkafi-Koubaa, Ines ELBini-Dhouib, Soumaya Souid, Jed Jebali, Raoudha Doghri, Najet Srairi-Abid, Khadija Essafi-Benkhadir, Olivier Micheau, Naziha Marrakchi   +8 more
doaj   +1 more source

Microfluidic Lab-on-a-Chip Based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells

Biosensors, 2021
Glioblastoma (GBM) is one of the most aggressive solid tumors, particularly due to the presence of cancer stem cells (CSCs). Nowadays, the characterization of this cell type with an efficient, fast and low-cost method remains an issue.
Elisa Lambert, Rémi Manczak, Elodie Barthout, Sofiane Saada, Elena Porcù, Francesca Maule, Barbara Bessette, Giampietro Viola, Luca Persano, Claire Dalmay, Fabrice Lalloué, Arnaud Pothier   +11 more
doaj   +1 more source

Can ECIS Biosensor Technology Be Used to Measure the Cellular Responses of Glioblastoma Stem Cells?

Biosensors, 2021
Glioblastoma is considered the most aggressive and lethal form of brain cancer. Glioblastoma tumours are complex, comprising a spectrum of oncogenically transformed cells displaying distinct phenotypes.
Laverne Diana Robilliard, Jane Yu, Sung-Min Jun, Akshata Anchan, Graeme Finlay, Catherine E. Angel, Euan Scott Graham   +6 more
doaj   +1 more source

Glioblastoma Microenvironment: From an Inviolable Defense to a Therapeutic Chance

Frontiers in Oncology, 2022
Glioblastoma is an aggressive tumor and is associated with a dismal prognosis. The availability of few active treatments as well as the inexorable recurrence after surgery are important hallmarks of the disease.
Vincenzo Di Nunno, Enrico Franceschi, Alicia Tosoni, Lidia Gatto, Stefania Bartolini, Alba Ariela Brandes   +5 more
doaj   +1 more source

TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells

Redox Biology, 2022
Objective: Glioblastoma is one of the most common intracranial malignant tumors with an unfavorable prognosis, and iron metabolism as well as ferroptosis are implicated in the pathogenesis of glioblastoma.
Kaiqiang Li, Bingyu Chen, Aibo Xu, Jinglan Shen, Kaixuan Li, Ke Hao, Rongrong Hao, Wei Yang, Wanli Jiang, Yongfa Zheng, Feihang Ge, Zhen Wang   +11 more
doaj   +1 more source

Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis

Journal of Translational Medicine, 2022
Background Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells.
Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen, Hu Wang   +8 more
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What is the role of CRP in glioblastoma?

Cancer Treatment and Research Communications, 2021
Background: Glioblastoma is the most common primary malignant brain tumor in adults. Previous studies have suggested that CRP (C-reactive protein) could serve as a biomarker candidate as well as a prognostic factor in glioblastoma patients, and we here ...
Karolina Förnvik, Aida Maddahi, Emma Liljedahl, Kurt Osther, Leif G. Salford, Henrietta Nittby Redebrandt   +5 more
doaj   +1 more source

Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. [PDF]

PLoS ONE, 2012
A major challenge in cancer research field is to define molecular features that distinguish cancer stem cells from normal stem cells. In this study, we compared microRNA (miRNA) expression profiles in human glioblastoma stem cells and normal neural stem ...
Ming-Fei Lang, Su Yang, Chunnian Zhao, Guoqiang Sun, Kiyohito Murai, Xiwei Wu, Jinhui Wang, Hanlin Gao, Christine E Brown, Xiaoxuan Liu, Jiehua Zhou, Ling Peng, John J Rossi, Yanhong Shi   +13 more
doaj   +1 more source