Results 31 to 40 of about 4,624,933 (258)

Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1

Frontiers in Pharmacology, 2021
Brusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is known regarding its role and underlying mechanism in glioblastoma cells.
Zhang’an Dai, Lin Cai, Lin Cai, Yingyu Chen, Silu Wang, Qian Zhang, Chengde Wang, Ming Tu, Zhangzhang Zhu, Qun Li, Xianghe Lu   +10 more
doaj   +1 more source

Adaptive Changes of Glioblastoma Cells Following Exposure to Hypoxic (1% Oxygen) Tumour Microenvironment [PDF]

, 2019
Glioblastoma multiforme is the most aggressive and malignant primary brain tumour, with a median survival rate of between 15 to 17 months. Heterogeneous regions occur in glioblastoma as a result of oxygen gradients which ranges from 0.1% to 10% in vivo ...
Musah-Eroje, Ahmed, Sue Watson, Ahmed Musah-Eroje, Watson, Sue   +3 more
core   +1 more source

Cytotoxic activity and Magnetic Behavior of green synthesized iron oxide nanoparticles on brain glioblastoma cells [PDF]

Nanomedicine Research Journal, 2022
Iron oxide nanoparticles are one of the most applied metal nanoparticles with advantageous properties in biomedicine that can be cost-effectively and rapidly produced through green synthesizing methods. The purpose of this study was to study the toxicity
Majid Reza Akbarizadeh, Mahin Naderifar, Farideh Mousazadeh, Niloofar Zafarnia, Mina Sarani   +4 more
doaj   +1 more source

The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]

, 2011
Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core   +1 more source

Knock-Down of Mucolipin 1 Channel Promotes Tumor Progression and Invasion in Human Glioblastoma Cell Lines

Frontiers in Oncology, 2021
Among cancers that affect the central nervous system, glioblastoma is the most common. Given the negative prognostic significance of transient receptor potential mucolipin 1 (TRPML1) channel reduction in patients with glioblastoma, as discussed in ...
Giorgio Santoni, Consuelo Amantini, Massimo Nabissi, Federica Maggi, Antonietta Arcella, Oliviero Marinelli, Anna Maria Eleuteri, Matteo Santoni, Maria Beatrice Morelli   +8 more
doaj   +1 more source

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]

, 2013
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Mittelbronn, Michel Guy André, Janina Seznec, Michel Mittelbronn, Jürgen Schlegel, Surowiak, Pawel, Ulrike Naumann, Klaus Mantwill, Naumann, Ulrike, Vroni Girbinger, Per Holm, Dagmar Beier, Girbinger, Vroni, Lage, Hermann, Holm, Per Sonne, Pawel Surowiak, Hermann Lage, Schlegel, Jürgen, Beier, Dagmar, Seznec, Janina, Mantwill, Klaus   +19 more
core   +1 more source

NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis

Cell Death Discovery, 2023
Cell fate and proliferation ability can be transformed through reprogramming technology. Reprogramming glioblastoma cells into neuron-like cells holds great promise for glioblastoma treatment, as it induces their terminal differentiation.
Hao Wang, Peiqi Zhao, Ying Zhang, Zhen Chen, Han Bao, Wenqi Qian, Jian Wu, Zhenqiu Xing, Xiaowei Hu, Kunlin Jin, Qichuan Zhuge, Jianjing Yang   +11 more
doaj   +1 more source

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

EMBO Molecular Medicine, 2016
A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor‐initiating cells isolated from patients with glioblastoma.
Suzana Assad Kahn, Silvia Lima Costa, Sharareh Gholamin, Ryan T Nitta, Luiz Gustavo Dubois, Marie Fève, Maria Zeniou, Paulo Lucas Cerqueira Coelho, Elias El‐Habr, Josette Cadusseau, Pascale Varlet, Siddhartha S Mitra, Bertrand Devaux, Marie‐Claude Kilhoffer, Samuel H Cheshier, Vivaldo Moura‐Neto, Jacques Haiech, Marie‐Pierre Junier, Hervé Chneiweiss   +18 more
doaj   +1 more source

Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma

Cell Stress, 2019
Glioblastoma, also known as glioblastoma multiforme, is the most common and deadliest form of high-grade malignant brain tumors with limited available treatments.
Woong-Jai Won, Jessy S. Deshane, Jianmei W. Leavenworth, Claudia R. Oliva, Corinne E. Griguer   +4 more
doaj   +1 more source

A preliminary study on transforming growth factor⁃β combined with CD3+, CD4+, CD8+ T cells in detecting the immune microenvironment of glioblastoma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Objective To analyze the expression of immune cells and immunosuppressive factors in the immune microenvironment of glioblastoma. Methods A total of 30 glioma specimens, all of which were glioblastoma (IDH⁃wildtype), were surgically removed and ...
LIU Min⁃ting, DAI Li⁃jun , ZHANG Zhen⁃bin , SHAO Yuan, LAI Ming⁃yao , ZHANG Xiao⁃tan   +5 more
doaj   +1 more source