Combinatorial strategy using protein kinase inhibitors and a cytotoxic compound for highly resistant glioblastoma cells : "in vitro studies" [PDF]
, 2007 Glioblastoma multiforme (GBM) is the most frequent and the most aggesssive malignant neoplasm of the human central nervous system (CNS), with a median survival of less than one year. These neoplasms are radio- and chemo-resistant, and are highly invasive,
Failly, Mike
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Acta Neuropathologica Communications, 2023 Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. The exact mechanisms of glioblastoma oncogenesis, including the identification of the glioma-initiating cell, are yet to be discovered.
F. Ah-Pine +6 more
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The Role of NKT Cells in Glioblastoma
Cells, 2021 Glioblastoma is an aggressive and deadly cancer, but to date, immunotherapies have failed to make significant strides in improving prognoses for glioblastoma patients.
Emily E. S. Brettschneider +1 more
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Strategies of eradicating glioma cells : a multi-scale mathematical model with miR-451-AMPK-mTOR control [PDF]
, 2015 The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of primary brain cancer, depends critically on the migration patterns after surgery and intracellular responses of the individual cancer cells in response to ...
Gibin Powathil +28 more
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Biomedicines, 2021 Up to now, the chemotherapy approaches for glioblastoma were limited. 1-[2-Thiazolylazo]-2-naphthol (named as NSC139021) was shown to significantly inhibit the proliferation of prostate cancer cells by targeting the atypical protein kinase RIOK2.
Min Yu +5 more
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EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice [PDF]
, 2005 Background: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12–14 mo from the time of diagnosis.
Levitzki, Alexander +15 more
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Effects of glioblastoma-derived extracellular vesicles on the functions of immune cells
Frontiers in Cell and Developmental Biology, 2023 Glioblastoma is the most aggressive variant of glioma, the tumor of glial origin which accounts for 80% of brain tumors. Glioblastoma is characterized by astoundingly poor prognosis for patients; a combination of surgery, chemo- and radiotherapy used for
Oxana E. Musatova +2 more
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Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells
BMC Cancer, 2020 Background Glioblastoma is devastating cancer with a high frequency of occurrence and poor survival rate and it is urgent to discover novel glioblastoma-specific antigens for the therapy. Cancer-germline genes are known to be related to the formation and
Fengyu Zhang +5 more
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Identifying the role of Mer receptor tyrosine kinase in glioblastoma multiforme [PDF]
, 2012 GBM is one of the most aggressive human cancers. Primary GBM, which comprises more than 90% of biopsied or resected brain tumors, arises de novo without an antecedent history of low-grade disease.
Yuhua, Wang
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Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]
, 2012 In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Mittelbronn, Michel Guy André +8 more
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