Results 41 to 50 of about 119,648 (139)

Bioinformatics analysis of missense SNPs in the ERN1 and TRAF2 genes associated with huntington's disease [PDF]

, 2023
Huntington hastalığı, kromozomun 4ncü kolundaki HTT geni içerisindeki CAG trinükleotitlerinin tekrarlanmasından kaynaklanan, beyin nöronlarında ağır dejenerasyona neden olan ve ölümle sonuçlanabilen bir hastalıktır.
TANRIVERDİ, Nurbanu
core  

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, Volume 13, Issue 42, 28 July 2026.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

THE IMPACT OF GRAPHENE OXIDE NANOPARTICLES ON THE EXPRESSION OF ENDOPLASMIC RETICULUM STRESS-DEPENDENT GENES IS MORE PRONOUNCED IN NORMAL HUMAN ASTROCYTES THAN GLIOBLASTOMA CELLS [PDF]

Biotechnologia Acta
Aim. The purpose of the study was to investigate the impact of graphene oxide nanoparticles on the expression of a subset of ER stress-dependent genes in normal human astrocytes in comparison with glioblastoma cells depending on the knockdown of ERN1.
O.V. RUDNYTSKA, Y.V. KULISH, O.O. KHITA, Y. M. VILETSKA   +3 more
doaj   +1 more source

Endoplasmic reticulum stress-dependent regulation of the expression of serine hydroxymethyltransferase 2 in glioblastoma cells

Endocrine Regulations
Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis).
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O.   +6 more
doaj   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Endoplasmic reticulum stress-dependent regulation of carboxypeptidase E expression in glioblastoma cells

Endocrine Regulations
Objective. Carboxypeptidase E (CPE) plays an important role in the biosynthesis of neurotransmitters and peptide hormones including insulin. It also promotes cell proliferation, survival, and invasion of tumor cells.
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khita Olena O., Sliusar Myroslava Y., Viletska Yuliia M., Minchenko Dmytro O.   +5 more
doaj   +1 more source

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer

, 2016
Cancers are heterogeneous by nature. While traditional oncology screens commonly use a single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal alternative targets that regulate cellular growth by processes other ...
Castro, David J., Au, Qingyan, Bronsert, Peter, Boerries, Melanie, Strietz, Juliane, Maurer, Jochen, Heynen-Genel, Susanne, Preca, Bogdan-Tiberius, Busch, Hauke, Stepputtis, Stella S., Oshima, Robert G., Kim, Mihee M., Aza-Blanc, Pedro, Vannier, Corinne, Brabletz, Thomas, Stickeler, Elmar, Kuster, Bernhard   +16 more
core   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Transplacental innate immune training via maternal microbial exposure: role of XBP1-ERN1 axis in dendritic cell precursor programming [PDF]

, 2020
We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional ...
Strickland, Deborah H, Scott, N.M., Stumbles, P.A., Bodinier, Marie, Mincham, K.T., Bosco, A., Bosco, Anthony, Holt, P.G., Jones, Anya C, Holt, Patrick G, Lauzon-Joset, J-F, Scott, Naomi M, Bodinier, M., Lauzon-Joset, Jean-Francois, Jones, A.C., Stumbles, Philip A, Mincham, Kyle T, Strickland, D.H.   +17 more
core   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source