Results 41 to 50 of about 1,657 (154)

Inhibition of ERN1 signaling enzyme affects hypoxic regulation of the expression of E2F8, EPAS1, HOXC6, ATF3, TBX3 and FOXF1 genes in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2015
Hypoxia as well as the endoplasmic reticulum stress are important factors of malignant tumor growth and control of the expression of genes, which regulate numerous metabolic processes and cell proliferation.
O. H. Minchenko, D. O. Tsymbal, D. O. Minchenko, O. V. Kovalevska, L. L. Karbovskyi, A. Bikfalvi   +5 more
doaj   +1 more source

Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer. [PDF]

, 2022
BACKGROUND Oncogenic KRAS mutations are prevalent in human cancers, but effective treatment of KRAS-mutant malignancies remains a major challenge in the clinic.
Chen, Chun, Dorn, Patrick, Gao, Yanyun, Hegedüs, Balazs, Kocher, Gregor J, Marti, Thomas M, Peng, Ren-Wang, Schmid, Ralph A, Shun-Qing, Liang, Wang, Wenxiang, Yang, Haitang, Yang, Zhang, Zhao, Liang, Zheng, Bin   +13 more
core   +1 more source

THE MULTIFACETED ROLE OF ENDOPLASMIC RETICULUM STRESS IN THE REGULATION OF GENE EXPRESSION IN NORMAL ASTROCYTES AND GLIOBLASTOMA CELLS [PDF]

Biotechnologia Acta
Aim. To determine the role of the endoplasmic reticulum (ER) in regulating gene expression in normal astrocytes and glioblastoma cells under the application of carbon nanoparticles as anti-tumor agents. Methods.
O.V. Rudnytska
doaj   +1 more source

Fucoxanthin Ameliorates MASLD by Directly Targeting GRP78 to Restore ER Homeostasis and Activate AMPK Signaling

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Proposed model of fucoxanthin in ameliorating MASLD via the GRP78‐AMPK axis. In MASLD, excessive lipid accumulation (FFA, TG, DNL) leads to ER stress activation (upregulation of CHOP, ATF6, IRE1) and GRP78 dysfunction, promoting hepatic lipid droplet (LD) formation. Fucoxanthin directly binds to GRP78, which in turn activates AMPK signaling.
Lin Zhang, Ruifen Zhang, Yu Wu, Binbin Chen, Chao Wang, Cheng Wang, Zhengshun Wen, Jingui Zhang, Haibin Tong, Liang Hong   +9 more
wiley   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Reprogramming of root cells during nitrogen-fixing symbiosis involves dynamic polysome association of coding and noncoding RNAs [PDF]

, 2020
Translational control is a widespread mechanism that allows the cell to rapidly modulate gene expression in order to provide flexibility and adaptability to eukaryotic organisms.
Bailey Serres, Julia, Blanco, Flavio Antonio, Hobecker, Karen Vanesa, Hummel, Maureen, Lancia, Marcos, Reynoso, Mauricio Alberto, Rosen, Benjamin, Town, Christopher, Traubenik, Laura Soledad, Zanetti, María Eugenia   +9 more
core   +2 more sources

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways [PDF]

, 2022
Macroautophagy (autophagy) has been a highly conserved process throughout evolution and allows cells to degrade aggregated/misfolded proteins, dysfunctional or superfluous organelles and damaged macromolecules, in order to recycle them for biosynthetic ...
Brogi S., Calderone V., Citi V., da Silva Rosa S. C., Ghavami S., Grabarek B. O., Klionsky D. J., Lorzadeh S., Los M. J., Martelli A., Mehrbod P., Nabavi S. F., Nabavi S. M., Omrani M., Staszkiewicz R., Sureda A., Zarghooni M.   +16 more
core   +1 more source

The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis‐Related Inflammation and Lipid Accumulation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Endoplasmic reticulum stress (ER stress) is closely related to the pathogenesis of atherosclerosis through various mechanisms, including inflammatory responses and foam cell formation. However, the mechanisms by which ER stress contributes to atherosclerosis require further elucidation. In this study, we investigate the impact of the inositol‐requiring
Mariam Bagheri Ekta, Natalia Elizova, Stanislav Antonov, Alexander Orekhov, Vasily Sukhorukov, Coman Cristin   +5 more
wiley   +1 more source

Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer [PDF]

, 2022
Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and is important for prostate cancer viability.
Cheung, Kathleen, Duxfield, Adam, Elliott, David, Garnham, Rebecca, Munkley, Jennifer, Scott, Emma   +5 more
core   +3 more sources