Results 51 to 60 of about 119,648 (139)

The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis‐Related Inflammation and Lipid Accumulation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Endoplasmic reticulum stress (ER stress) is closely related to the pathogenesis of atherosclerosis through various mechanisms, including inflammatory responses and foam cell formation. However, the mechanisms by which ER stress contributes to atherosclerosis require further elucidation. In this study, we investigate the impact of the inositol‐requiring
Mariam Bagheri Ekta, Natalia Elizova, Stanislav Antonov, Alexander Orekhov, Vasily Sukhorukov, Coman Cristin   +5 more
wiley   +1 more source

Hypoxic regulation of the expression of anti-angiogenic genes in U87 glioma cells with loss of function of ern1 signaling enzyme [PDF]

, 2012
The angiogenesis is an important component of tumor growth and tightly associated with hypoxia. The expression level of genes related to regulation of angiogenesis (BAI2, SPARC, TIMP1, TIMP2, TIMP3, TIMP4, THBS1, THBS2, ADAMTS5 and FGF2) in glioma ...
A. Y. Kuznetsova, K. I. Kubaichuk, D. O. Minchenko, A. K. Jassim, S. V. Danilovskyi, O. H. Minchenko   +5 more
core   +1 more source

Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules

Journal of Integrative Plant Biology, Volume 67, Issue 10, Page 2624-2642, October 2025.
A 3D genomic map of peanut nodules revealed that the nodules exhibit chromatin reorganization, with 2% of regions transitioning to active states, altered topologically associating domains and enhanced cis interactions. The identification of chromatin loops that regulate nodulation genes links 3D genome dynamics to symbiotic nitrogen fixation.
Lixiang Wang, Chunhai Mai, Suqin He, Bingjie Niu, Gaiya Jia, Tao Yang, Yiwei Xu, Meng Ren, Xiaorui Zhao, Xin Liu, Zhaosheng Kong   +10 more
wiley   +1 more source

Dasatinib treatment causes TRAIL expression on the mRNA level and proteasome inhibitor treatment leads to ERN1/XBP1 expression.

, 2022
Ph+ ALL cells TOM-1 and BV-173 were treated with dasatinib, proteasome inhibitor bortezomib or ixazomib and the combination of dasatinib and proteasome inhibitor. qPCR was performed after 24h of treatment. (A) Dasatinib induces a significant upregulation
Margherita Vieri (3482504), Mirle Schemionek (151019), Azam Salimi (13003755), Kema Marlen Schroeder (13003758), Behzad Kharabi Masouleh (13003770), Steffen Koschmieder (106779), Saskia Maletzke (13003764), Tim H. Brümmendorf (9263733), Iris Appelmann (365795)   +8 more
core   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma

The Journal of Pathology, Volume 266, Issue 3, Page 247-257, July 2025.
Abstract The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were associated with chordomas and with the variant rs2305089 A‐allele with enrichment of the AA ...
Inga Usher, Paul O'Donnell, Lorena Ligammari, Dorothee Harder, Wendy Brown, David Choi, Paul Cool, Lucia Cottone, Adrienne M Flanagan   +8 more
wiley   +1 more source

Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes

FEBS Open Bio, 2014
The fatty acid binding protein 4 (FABP4), one of the most abundant proteins in adipocytes, has been reported to have a proinflammatory function in macrophages. However, the physiological role of FABP4, which is constitutively expressed in adipocytes, has
Kazuaki Kajimoto, Yoshitaka Minami, Hideyoshi Harashima   +2 more
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, Volume 19, Issue 6, Page 1687-1706, June 2025.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Metabolomics in ERN1 and ERN1-DeltaR liver samples

ERN1 and ERN1-DeltaR High fat diet (HFD) liver samples (WT (ND :normal diet), KO (ND: normal diet), WT (HFD) and KO (HFD): & samples in each group) ERN1 and ERN1-DeltaR High fat diet (CCl4 treatment) liver samples (WT (Olive oil), KO (Olive oil), WT ...
Hazari, Younis
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source