Results 51 to 60 of about 1,657 (154)

Endoplasmic reticulum stress-dependent regulation of carboxypeptidase E expression in glioblastoma cells

Endocrine Regulations
Objective. Carboxypeptidase E (CPE) plays an important role in the biosynthesis of neurotransmitters and peptide hormones including insulin. It also promotes cell proliferation, survival, and invasion of tumor cells.
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khita Olena O., Sliusar Myroslava Y., Viletska Yuliia M., Minchenko Dmytro O.   +5 more
doaj   +1 more source

Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules

Journal of Integrative Plant Biology, Volume 67, Issue 10, Page 2624-2642, October 2025.
A 3D genomic map of peanut nodules revealed that the nodules exhibit chromatin reorganization, with 2% of regions transitioning to active states, altered topologically associating domains and enhanced cis interactions. The identification of chromatin loops that regulate nodulation genes links 3D genome dynamics to symbiotic nitrogen fixation.
Lixiang Wang, Chunhai Mai, Suqin He, Bingjie Niu, Gaiya Jia, Tao Yang, Yiwei Xu, Meng Ren, Xiaorui Zhao, Xin Liu, Zhaosheng Kong   +10 more
wiley   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma

The Journal of Pathology, Volume 266, Issue 3, Page 247-257, July 2025.
Abstract The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were associated with chordomas and with the variant rs2305089 A‐allele with enrichment of the AA ...
Inga Usher, Paul O'Donnell, Lorena Ligammari, Dorothee Harder, Wendy Brown, David Choi, Paul Cool, Lucia Cottone, Adrienne M Flanagan   +8 more
wiley   +1 more source

NIPK, a protein pseudokinase that interacts with the C subunit of the transcription factor NF-Y, is involved in rhizobial infection and nodule organogenesis [PDF]

, 2022
Heterotrimeric Nuclear Factor Y (NF-Y) transcription factors are key regulators of the symbiotic program that controls rhizobial infection and nodule organogenesis.
Battaglia, Marina Esther, Blanco, Flavio Antonio, Clua, Joaquin, Roda, Carla Lucía, Rípodas, Carolina, Zanetti, María Eugenia   +5 more
core   +1 more source

Endoplasmic reticulum stress-dependent regulation of the expression of serine hydroxymethyltransferase 2 in glioblastoma cells

Endocrine Regulations
Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis).
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O.   +6 more
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, Volume 19, Issue 6, Page 1687-1706, June 2025.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes

FEBS Open Bio, 2014
The fatty acid binding protein 4 (FABP4), one of the most abundant proteins in adipocytes, has been reported to have a proinflammatory function in macrophages. However, the physiological role of FABP4, which is constitutively expressed in adipocytes, has
Kazuaki Kajimoto, Yoshitaka Minami, Hideyoshi Harashima   +2 more
doaj   +1 more source

Orchestrating Neural Development Through mRNA Translation Regulation

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review provides an overview of mRNA translation mechanisms that control prenatal brain development, including cortical lamination, progenitor differentiation, and axon guidance, and identifies significant knowledge gaps. Specifically, we focus on mRNA translation regulation through signaling cascades such as the mammalian/mechanistic target of ...
Brandon Rodrigue, Mathew Sajish, Natalina Salmaso, Argel Aguilar‐Valles   +3 more
wiley   +1 more source