Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease
Aging Cell, Volume 23, Issue 10, October 2024.MEIS2 promotes amyloid cleavage of β amyloid precursor protein through transcriptional regulation of BACE1. Abstract Amyloid plaques, a major pathological hallmark of Alzheimer's disease (AD), are caused by an imbalance between the amyloidogenic and non‐amyloidogenic pathways of amyloid precursor protein (APP).
Yuting Cui +10 more
wiley +1 more source
Ire1α Rnase-Dependent Lipid Homeostasis Promotes Survival In Myc-Transformed Cancers [PDF]
, 2018 Myc family activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting that Myc-dependent downstream effectors may be more tractable therapeutic targets. Here,
Xie, Hong
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Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus [PDF]
金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：Cellular and Molecular Gastroenterology and Hepatology 16(2) pp.263-286 2023. Elsevier. 共著者：Masashi Nishikawa, Hikari Okada, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Tatsuya Yamashita, Motoko ...
NISHIKAWA MASASHI, 西川 昌志
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Endocrine RegulationsObjective. For the effective growth of malignant tumors, including glioblastoma, the necessary factors involve endoplasmic reticulum (ER) stress, hypoxia, and the availability of nutrients, particularly glucose.
Minchenko Oleksandr H. +6 more
doaj +1 more source
THP-1ヒト単球細胞においてツニカマイシン誘発小胞体ストレスはPERK-ATF4-CHOP経路を介してレジスチンmRNAを増加させる [PDF]
甲医博第806号Ehime University (愛媛大学)Doctral(includes post-doctral)博士 ...
濱田, 淳平
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REGULATION OF CALCIUM INFLUX AND REACTIVE OXYGEN SPECIES PRODUCTION DURING INFECTION OF LEGUMES BY RHIZOBIA [PDF]
, 2014 Nod factor (NF) can induce two separate calcium responses in legume root hairs. Nuclear-associated calcium spiking is central to the symbiosis signalling (Sym) pathway, which is necessary for the activation of genes required for nodule formation and ...
Shailes, Sarah
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Chaperones, protein homeostasis & protein aggregation diseases [PDF]
, 2014 Eiwitten zijn de werkzame moleculen van cellen en moeten in een specifieke driedimensionale structuur zijn gevouwen. Niet gevouwen eiwitten zijn niet alleen niet-functioneel, maar kunnen samenklonteren en aggregaten vormen die ziektes kunnen veroorzaken (
Minoia, Melania
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Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells [PDF]
, 2014 BACKGROUND: Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on.
Ling Su, Xiangguo Liu, Xiaofei Zhao
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Endocrine RegulationsObjective. Nanographene oxide (nGO) nanoparticles (NPs) have unique properties and are widely used in various fields, including biomedicine. These NPs, however, also exhibit toxic effects and therefore, the understanding of the molecular mechanism of ...
Minchenko Oleksandr +6 more
doaj +1 more source
Characterisation and expression of Receptor-like Cytoplasmic Kinases in Medicago truncatula during Rhizobial and Arbuscular Mycorrhizal symbioses [PDF]
, 2015 Legume plants have evolved the ability to form a mutualistic symbiosis with nitrogen-fixing bacteria known as rhizobia. Studies using mutant Medicago truncatula and Lotus japonicus have identified many genes that are necessary for this mutualism. Some of
Jackson, Kirsty
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