Results 61 to 70 of about 1,657 (154)

RNA therapy for oncogenic NRAS-driven naevi induces apoptosis [PDF]

RAS proteins regulate cell division, differentiation and apoptosis via multiple downstream effector pathways. Oncogenic RAS variants are the commonest drivers in cancers, however they also drive many benign lesions predisposing to malignancy, such as ...
Baird, William, Barberan-Martin, Sara, Bennett, Dorothy C, Bryant, Dale, Demetriou, Charalambos, Hart, Stephen, Jones, Phoebe, Kinsler, Veronica A, Knöpfel, Nicole, Maeshima, Ruhina, Michailidis, Fanourios, Pittman, Alan, Polubothu, Satyamaanasa, Rabii, Mohammad, Riachi, Melissa, Sauvadet, Aimie, Torres, Ignacio Del Valle, Zecchin, Davide   +17 more
core   +4 more sources

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

Cell Proliferation, Volume 58, Issue 5, May 2025.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei, Mengting Wei, Haonan Huang, Ting Fan, Zhichang Zhang, Xiaoyu Song   +5 more
wiley   +1 more source

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis [PDF]

, 2021
Summary DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown.
Asby, R, Barrans, S, Beer, P, Blain, AE, Bornelov, S, Burke, GAA, Burton, C, Campbell, P, Cucco, F, De Los Mozos, IR, Du, M-Q, Forde, S, Gao, J, Giotopoulos, G, Gong, C, Grigoropoulos, NF, Haupl, B, Hodson, DJ, Huntly, BJ, Krupka, JA, Matthews, J, Meng, W, Oellerich, T, Painter, D, Rand, V, Roman, E, Samarajiwa, SA, Screen, M, Sze, SK, Tan, MGK, Tooze, R, Turner, M, Turner, SD, Ule, J, Usheva, Z, Zaini, NBM, Zhou, P   +36 more
core  

Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects

Glia, Volume 73, Issue 3, Page 539-573, March 2025.
Main Point Graphical overview of the literature summarized in this review, spanning glia cells and levels of omics analysis present on Alzheimer's disease. ABSTRACT Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐layered complexity in its molecular etiology.
Özkan İş, Yuhao Min, Xue Wang, Stephanie R. Oatman, Ann Abraham Daniel, Nilüfer Ertekin‐Taner   +5 more
wiley   +1 more source

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Exploration, Volume 5, Issue 1, February 2025.
Within this review, an in‐depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune‐mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs ...
Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun   +10 more
wiley   +1 more source

CCR1 as a therapeutic target in multiple myeloma: preventing tumour dissemination and therapeutic resistance [PDF]

, 2020
Multiple myeloma (MM) is a haematological malignancy characterised by the clonal proliferation of plasma cells (PC) within the bone marrow (BM). While the introduction of novel therapies, such as the proteasome inhibitor bortezomib, has greatly improved ...
Zeissig, Mara Natasha
core  

14‐3‐3σ restricts YY1 to the cytoplasm, promoting therapy resistance, and tumor progression in colorectal cancer

International Journal of Cancer, Volume 156, Issue 3, Page 623-637, 1 February 2025.
What's new? 14‐3‐3σ functions as an oncogene in colorectal cancer and is associated with therapy resistance. However, the underlying mechanisms remain unclear. Here, the authors show that 14‐3‐3σ restricts the localization of the transcription factor YY1 to the cytoplasm, preventing it from repressing genes of the unfolded protein response pathway ...
Amol Lonare, Kumarkrishna Raychaudhuri, Sanket Shah, Gifty Madhu, Anoushka Sachdeva, Sneha Basu, Rahul Thorat, Sanjay Gupta, Sorab N. Dalal   +8 more
wiley   +1 more source

Emerging role of IRE1α in vascular diseases

Journal of Cell Communication and Signaling, Volume 18, Issue 4, December 2024.
The IRE1α signaling pathway plays a critical role in the pathology of various vascular diseases. Abstract A mounting body of evidence suggests that the endoplasmic reticulum stress and the unfolded protein response are involved in the underlying mechanisms responsible for vascular diseases. Inositol‐requiring protein 1α (IRE1α), the most ancient branch
Jia Shi, Fan He, Xiaogang Du
wiley   +1 more source

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Medicinal Research Reviews, Volume 44, Issue 6, Page 2472-2509, November 2024.
Abstract Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response ...
Yuchen He, Yishu Fan, Xenab Ahmadpoor, Yumin Wang, Zhong Alan Li, Weihong Zhu, Hang Lin   +6 more
wiley   +1 more source

Effect of hypoxia and ischemia on the expression of phosphofructokinase-1 and lactate dehydrogenase genes in glioma U87 cells with ERN1 knockdown

Физика живого, 2011
Клітини злоякісних пухлин переважно використовують гліколіз для задоволення своїх підвищених енергетичних та біосинтетичних потреб. Ми досліджували вплив гіпоксії та ішемії, що є важливими факторами неоваскуляризації та росту пухлин, на експресію генів таких ензимів гліколізу як фосфофруктокіназа-1 (PFKL, PFKM і PFKP) та лактатдегідрогеназа (LDHA і ...
Marunych, R., Minchenko, D., Kubaichuk, K., Bakalets, T., Minchenko, O.   +4 more
openaire   +1 more source