Results 61 to 70 of about 119,648 (139)

Orchestrating Neural Development Through mRNA Translation Regulation

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review provides an overview of mRNA translation mechanisms that control prenatal brain development, including cortical lamination, progenitor differentiation, and axon guidance, and identifies significant knowledge gaps. Specifically, we focus on mRNA translation regulation through signaling cascades such as the mammalian/mechanistic target of ...
Brandon Rodrigue, Mathew Sajish, Natalina Salmaso, Argel Aguilar‐Valles   +3 more
wiley   +1 more source

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers [PDF]

, 2018
Background Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials.
Tonći Šuštić, Beijersbergen, Roderick L., Bosdriesz, Evert, Evert Bosdriesz, Bosdriesz, Evert; id_orcid, van Wageningen, Sake, Wessels, Lodewyk F. A., Bernards, René, John Dittmar, Wessels, Lodewyk F A, Dittmar, John, Sake van Wageningen, Roderick L. Beijersbergen, René Bernards, Robert J. D. Reid, Cor Lieftink, Reid, Robert J D, Šuštić, Tonći, Rothstein, Rodney, Reid, Robert J. D., Lodewyk F. A. Wessels, Beijersbergen, Roderick L, Lieftink, Cor, Rodney Rothstein   +23 more
core   +1 more source

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

Cell Proliferation, Volume 58, Issue 5, May 2025.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei, Mengting Wei, Haonan Huang, Ting Fan, Zhichang Zhang, Xiaoyu Song   +5 more
wiley   +1 more source

TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study

, 2020
Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
core   +1 more source

Lentivirus-mediated knockdown of P27RF-Rho inhibits hepatocellular carcinoma cell growth [PDF]

, 2017
Aim of the study: To investigate the effects of P27RF-Rho on hepatocellular carcinoma (HCC) cell growth and explore the possibility of using it as a novel therapeutic target for liver cancer treatment.
Guofu Chen, Guoyue Lv, Shuli Xie, Mingguang Zhu, Guangyi Wang   +4 more
core   +1 more source

ERN1 inhibition modifies hypoxic regulation of EGLN1 expression in U87MG glioblastoma cells

Objective. Glioblastomas are the most common and highly aggressive malignant brain tumors that are difficult to treat. Hypoxia is a significant factor in glioblastoma growth.
Olena O. Khita, Myroslava Y. Sliusar, Oleksandr H. Minchenko, Oleh V. Halkin, Dmytro O. Minchenko, Yuliia M. Viletska, Taia V. Feldman   +6 more
core   +1 more source

ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells

Endocrine Regulations
Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2)
Krasnytska Daria A., Khita Olena O., Viletska Yuliia M., Minchenko Dmytro O., Halkin Oleh V., Rudnytska Olha V., Hoian Sofiia L., Minchenko Oleksandr H.   +7 more
doaj   +1 more source

Analysis of the Troenan-induced effect in HCT116 cells containing a doxycycline-sensitive OR51B4-knockdown-sequence.

, 2017
(A) Confirmation of knockdown functionality by qRT-PCR and calcium imaging experiments. M = Marker. Stimulation of HCT116/EV (left) and HCT116/10F1 cells (right) with Troenan (100 μM/ 300 μM).
Stephan Hahn (534868), Janine Altmüller (120887), Juliane Ebbert (3821188), Hanns Hatt (120893), Günter Gisselmann (120878), Peter Jägers (3726508), Christian Becker (49615), Lea Weber (279365), Klaudia Al-Refae (3821185)   +8 more
core   +1 more source

Експресія генів синтезу серину в нормальних і пухлинних клітинах при інгібуванні ERN1 [PDF]

Методами молекулярної біології було проаналізовано роль пригнічення ферментативних активностей протеїна ERN1 у експресії генів синтезу серину, а також її взаємодію з сенсорно-сигнальним шляхом стресу ендоплазматичного ретикулума ERN1 у культурі клітин ...
Хіхло, Євген
core  

The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells

Endocrine Regulations
Objective. Nanographene oxide (nGO) nanoparticles (NPs) have unique properties and are widely used in various fields, including biomedicine. These NPs, however, also exhibit toxic ef­fects and therefore, the understanding of the molecular mechanism of ...
Minchenko Oleksandr, Kulish Yuliia V., Viletska Yuliia M., Khita Olena O., Rudnytska Olha V., Kozynkevych Halyna E., Minchenko Dmytro O.   +6 more
doaj   +1 more source