Results 61 to 70 of about 4,461,121 (140)
Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest. [PDF]
Evid Based Complement Alternat Med, 2022 Alharthy SA +6 more
europepmc +1 more source
Advanced Healthcare Materials, Volume 15, Issue 33, 4 September 2026.This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang +17 more
wiley +1 more source
Blockade of AREG from THP1 macrophages during U87 glioma invasion.
, 2021 THP1 macrophages differentiated with PMA were cocultured with U87 cells stained with Cell Tracker Dye CMFDA (Green) on Matrigel-coated invasion with control IgG antibody or AREG blocking antibody. Representative images are shown.
Salvatore J. Coniglio (11767263) +1 more
core +1 more source
Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma
Advanced Science, Volume 13, Issue 53, 24 September 2026.ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba +25 more
wiley +1 more source
, 2015 Background: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that mediate neuronal excitability and synaptic plasticity in the central nervous system, and emerging evidence suggests a role of mGluRs in the biology of cancer ...
Zi-jin Zhao +8 more
core +1 more source
IRE1 knockdown modifies hypoxic regulation of cathepsins and LONP1 genes expression in U87 glioma cells [PDF]
, 2017 We have studied the effect of hypoxia on the expression of genes encoding for LONP1/PRSS15 and cathepsins in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
О. O. Ratushna +4 more
core +2 more sources
Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley +1 more source
Modulação do sistema glutamatérgico por cisplatina em células de glioma humano e astrócitos corticais de ratos [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Neurociências, Florianópolis, 2013.Gliomas malignos constituem um grupo heterogêneo de tumores, com origem em precursores ...
Oliveira, Karen Andrinéia de
core
, 2019 Objective. The aim of the present investigation was to study the effect of hypoxia on the expression of genes encoding endothelin-1 (EDN1) and its cognate receptors (EDNRA and EDNRB) as well as endothelin converting enzyme 1 (ECE1) in U87 glioma cells in
Riabovol Olena O. +7 more
core +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.Nanomaterials integrate radiotherapy and immunotherapy by enhancing radiosensitivity, remodeling the immunosuppressive tumor microenvironment, and promoting systemic antitumor immunity. This review summarizes the latest strategies of nanomaterial‐mediated combinations (RT, immunotherapy, IRT) and highlights future directions for overcoming clinical ...
Peijie Li, Xiangqin Wang, Sisi He, Hu Ma
wiley +1 more source