Results 61 to 70 of about 23,643 (220)

Bmi-1 induces radioresistance by suppressing senescence in human U87 glioma cells

Oncology Letters, 2014
Radiotherapy is the main locoregional control modality for a number of types of malignant tumors, including glioblastoma. However, radiotherapy fails to prevent recurrence in numerous patients due to the intrinsic radioresistance of cancer cells.
YE, LAN, WANG, CUIHONG, YU, GUANYING, JIANG, YUHUA, SUN, DIANSHUI, ZHANG, ZAIYUN, YU, XIAOMING, LI, XIAOMEI, WEI, WEI, LIU, PING, CHENG, JIAN, DU, BIN, HU, LIKUAN   +12 more
openaire   +3 more sources

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

Immediate early gene IEX‐1 induces astrocytic differentiation of U87‐MG human glioma cells [PDF]

Journal of Cellular Biochemistry, 2006
AbstractThe immediate early response gene IEX‐1 is involved in the regulation of apoptosis and cell growth. In order to increase the apoptotic sensitivity to chemotherapeutic drugs and γ‐ray, we attempted to establish U87‐MG human glioma cell line expressing IEX‐1.
Fukka, You, Yosuke, Osawa, Shin-ichiro, Hayashi, Shigeru, Nakashima   +3 more
openaire   +2 more sources

Dexamethasone in glioblastoma multiforme therapy : mechanisms and controversies [PDF]

, 2019
Glioblastoma multiforme (GBM) is the most common and malignant of the glial tumors. The world-wide estimates of new cases and deaths annually are remarkable, making GBM a crucial public health issue.
Luigi Sforna, Maria Cristina D’Adamo, Mario Valentino, Marta Cenciarini, Mauro Pessia, Mauro Pessia, Paolo Rosa, Silvia Belia, Simona Ronchetti   +8 more
core   +2 more sources

Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas

Molecular Therapy: Oncolytics, 2017
Malignant glioma, the most common malignant brain tumor in adults, is difficult to treat due to its aggressive invasive nature. Enzyme/prodrug suicide gene therapy based on the herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) system is an ...
Tomohiro Yamasaki, Shohei Wakao, Hiroshi Kawaji, Shinichiro Koizumi, Tetsuro Sameshima, Mari Dezawa, Hiroki Namba   +6 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer [PDF]

, 2012
INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months.
A. A. Hill, A. Altinkaya, A. Baborie, A. Bahl, A. Brodbelt, A. Brodbelt, A. Brodbelt, A. Brodbelt, A. Chalmers, A. Dubocq, A. Eason, A. Elmahdi, A. Frary, A. Frary, A. Gerhard, A. Gullan, A. Hajitou, A. J. Frary, A. Jackson, A. James, A. James, A. Joannides, A. Kia, A. Niranjan, A. O'Brien, A. Shaw, A. Shenoy, A. Shivane, A. Shoakazemi, A. Singh, A. Singleton, A. Sofat, A. Sottoriva, A. Williamson, A. Young, A. Young, B. Hacking, B. Harding, B. Haylock, B. Haylock, B. Haylock, B. Herron, C. Chatelain, C. Crosby, C. Davis, C. Hanemann, C. L. Nigro, C. Lawrence, C. O. Hanemann, C. Romanowski, C. Schmidberger, C. Walker, C. Walker, C. Walker, C. Watts, C. Watts, C. Watts, D. A. Jellinek, D. Bowyer, D. Cavers, D. Conkey, D. Coope, D. Crooks, D. Crooks, D. Crooks, D. du Plessis, D. Elder, D. G. O'Donovan, D. Husband, D. J. Coope, D. Kondziolka, D. Parkinson, D. Sheer, D. Thompson, D. W. Ellison, E. A. Chiocca, E. Clarke, E. Ercolano, E. Goessl, E. Hatzimichael, E. Healy, E. McGrath, E. Murray, F. Harris, F. McKevitt, F. Roncaroli, F. Roncaroli, F. Rowther, F. Rowther, F. Rowther, F. Turkheimer, G. Cruickshank, G. Hall, G. Hall, G. J. Pilkington, G. J. Pilkington, G. Pilkington, G. Pilkington, G. Pilkington, G. Pilkington, G. Thompson, G. Wall, G. Zilidis, H. Coley, H. Dogra, H. Kano, H. Kardooni, H. Wong, I. C. Morley, I. Corbett, I. Craven, I. Nicholl, I. Noorani, I. Qaddoumi, I. R. Whittle, I. Spiteri, J. Alder, J. Baily, J. Bambrough, J. Bambrough, J. Bomalaski, J. Darling, J. Darling, J. Darling, J. Darling, J. Darling, J. Dunn, J. Dunn, J. Harney, J. Holliday, J. Ironside, J. Larsen, J. Leggate, J. Logan, J. M. Przystal, J. N. Jeyapalan, J. Simpson, J. Singh, J. Tavare, K. Ashkan, K. Ashkan, K. Ashton, K. Ashton, K. Ashton, K. Chen, K. Das, K. E. Hatherell, K. Herholz, K. Hopkins, K. Hopkins, K. Janczar, K. Karabatsou, K. Karabatsou, K. Karakoula, K. Karakoula, K. Kroese, K. M. Kurian, K. M. Kurian, K. M. Kurian, K. M. Prise, K. McCarthy, K. O'Neil, K. Phipps, K. Prise, L. Brazil, L. Donovan, L. Evans, L. Lattanzio, L. Lunsford, L. Mohsen, L. Rada, L. Shaw, L. Spinelli, L. Steele, L. Taggart, L. Wallace, L. Zhou, M. A. Mumin, M. Altinkaya, M. Anand, M. Anand, M. Arora, M. Barczyk, M. Boissinot, M. Bradley, M. C. Schmid, M. Diaz, M. Donnelly, M. Frame, M. Jenkinson, M. Jenkinson, M. Jenkinson, M. Keeling, M. Mackinnon, M. McLean, M. Morris, M. R. Morris, M. Williams, N. A. Pullen, N. A. Pullen, N. Burnet, N. Cohen, N. D. Mazarakis, N. Hoggard, N. Marko, N. Nianiaris, N. Potter, N. R. Leslie, N. Rathi, N. Rathi, N. Syed, O. Sansom, O. Thomas, P. Brennan, P. Collins, P. Grundy, P. J. Mintz, P. Metherall, P. Singh, P. Singh, P. Szlosarek, P. Tibarewal, P. Welsby, Q. An, R. Beaney, R. Bhangoo, R. Blake, R. Brock, R. G. Tatevossian, R. Grundy, R. Hamilton, R. Hayward, R. Hinz, R. Jackson, R. Jena, R. Lea, R. McConnell, R. Muirhead, R. P. Pangeni, R. Rahman, S. Al-Rashid, S. Ammoun, S. Ammoun, S. Bell, S. Bell, S. Birks, S. Birks, S. Birks, S. Birks, S. Green, S. Hafizi, S. Hafizi, S. Higgins, S. J. Price, S. J. Price, S. J. Price, S. Jefferies, S. Kokkinos, S. Lawler, S. Leow-Dyke, S. Leow-Dyke, S. Leow-Dyke, S. Mashal, S. McQuaid, S. Price, S. Price, S. Price, S. Price, S. Saini, S. Scott, S. Shepherd, S. Smith, S. T. Al Rashid, S. Tavare, S. Wilkins, S. Williams, S. Williams, T. Crook, T. Dawson, T. Dawson, T. Dawson, T. Flannery, T. Flannery, T. Gaissmaier, T. J. Warr, T. Jacques, T. Jaunky, T. Lawson, T. Smith, T. Van Meter, T. Warr, T. Warr, T. Warr, T. Warr, T. Warr, V. Beckett, V. Berry, V. Bosak, V. Brunton, V. Hurwitz, V. Iyer, V. Iyer, V. Lupson, V. Petinou, W. Harkness, W. Stewart, W. Stewart, Y. Majani, Y. Zhang, Z. Hanzely, Z. Hanzely, Z. Maherally, Z. Su   +312 more
core   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]

, 2017
Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio, D\u2019Avella, Domenico, Denaro, Luca, Mucignat-Caretta, Carla   +3 more
core   +2 more sources

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source