Results 91 to 100 of about 15,754,334 (318)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Journal of Biological Chemistry, 1999 We have identified a novel gene referred to asactivation-induced deaminase (AID) by subtraction of cDNAs derived from switch-induced and uninduced murine B lymphoma CH12F3-2 cells, more than 80% of which switch exclusively to IgA upon stimulation.
M. Muramatsu +6 more
semanticscholar +1 more source
HaematologicaAzacitidine/venetoclax combination is the standard of care for acute myeloid leukemia (AML) patients deemed unfit for intensive care programs, according to the VIALE-A trial results.
F. Tarantini +22 more
doaj
Reversed S-shaped connected component for a fourth-order boundary value problem
Advances in Difference Equations, 2017 In this paper, we investigate the existence of a reversed S-shaped component in the positive solutions set of the fourth-order boundary value problem { u ′′′′ ( x ) = λ h ( x ) f ( u ( x ) ) , x ∈ ( 0 , 1 ) , u ( 0 ) = u ( 1 ) = u ″ ( 0 ) = u ″ ( 1 ) = 0
Jinxiang Wang, Ruyun Ma
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Studies in Mycology, 2012 A monographic revision of the hyphomycete genus Cladosporium s. lat. (Cladosporiaceae, Capnodiales) is presented. It includes a detailed historic overview of Cladosporium and allied genera, with notes on their phylogeny, systematics and ecology.
K. Bensch +4 more
semanticscholar +1 more source
A general description of Loran-C: Present and potential applications [PDF]
Loran-C is a low frequency (100 kHz) pulse navigation system. The pulse format and phase stability of the system are of paramount importance for both navigation and time synchronization using this system.
Doherty, R. H.
core +1 more source