Results 41 to 50 of about 179,819 (285)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Challenges in the aviation system caused by the emergence of delivery drones
Acta Technica Jaurinensis, 2023 Using unmanned aerial systems is spreading in several industry sectors. New and previously not seen demands are evolving in the service industry. Due to the continuous technological development in the aviation and drone segment, this equipment can fulfil
Zsolt Sándor
doaj +1 more source
, 2021 Seluruh struktur sosial berkontribusi pada operasi masyarakat. Dua antropologinggris terkemuka Radcliff Brown dan Bronslaw Malinowski, menggambarkan duastandar teori: Struktural fungsionalisme, yang menekankan pada keunggulan darimasyarakat dan menyusun para individu, dan bagaimana berbagai macamelemenfungsi struktur sosial untuk memelihara permintaan ...
openaire +3 more sources
Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
Advanced Science, EarlyView.A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu +5 more
wiley +1 more source
Evaluation of diverse soybean genotypes for seed longevity and its association with seed coat colour
Scientific Reports, 2023 Sixty genotypes with different seed coat colour and seed sizes were evaluated for seed longevity under both natural and accelerated ageing over seasons.
Naflath T. V. +2 more
doaj +1 more source
Newspaper of the university of alaska southeast juneau campus [PDF]
, 1988 UAS/Soviet link sought -- Fish center remains active -- Student Council tables proposed constitution -- Whalesong campus survey: Will you vote for a separate system?
core
CORN SKELETON RECONSTRUCTION BY UAS-BASED STRUCTURE FROM MOTION [PDF]
, 2022 Mónica Herrero-Huerta
openalex +1 more source
Cytoskeleton, EarlyView.ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky +4 more
wiley +1 more source
HeliyonStorage pests, particularly bruchids, are major biotic constraints causing significant storage losses in pulses. Conventional control methods relying on insecticides and fumigants often lead to food contamination due to toxic pesticide residues and a ...
M. Hemalatha +5 more
doaj +1 more source