Results 151 to 160 of about 6,714 (194)

Cryo-EM structures reveal the molecular mechanism of SUMO E1-E2 thioester transfer. [PDF]

Nat Struct Mol Biol
Nayak A, Nayak D, Jia L, Ruben EA, Viswanadhapalli S, Dos Santos Bury P, Nassar KM, Yu CH, Tumanova AA, Stratton CM, Ebadi P, Ivanov DN, Sung P, Vadlamudi RK, Wasmuth EV, Olsen SK.   +15 more
europepmc   +1 more source

VEXAS: A review of current understandings and emerging treatment strategies. [PDF]

Front Immunol
Holden R, Jeelal Y, McLean-Tooke A, Pathmanathan K, Nolan D.   +4 more
europepmc   +1 more source

VEXAS syndrome: more than just vacuoles. [PDF]

Hematol Transfus Cell Ther
Barros Pinto MP.
europepmc   +1 more source

Vacuolated Marrow Cytopenias from Copper Deficiency to <i>UBA1</i>-Mutant VEXAS: Molecular Landscape, Systematic Review, and Cost-Efficient Diagnostic Algorithm. [PDF]

Int J Mol Sci
Takami A, Uchino K, Terashima M, Sato S, Kondo Y, Espinoza JL, Enomoto M.   +6 more
europepmc   +1 more source

Recurrent fever and association with severe organ involvement, mortality and treatment outcomes in VEXAS syndrome: data from the AIDA Network. [PDF]

Front Immunol
Caggiano V, Sbalchiero J, Frassi M, Crisafulli F, Cavazzana I, Hinojosa-Azaola A, Martín-Nares E, Guaracha-Basañez GA, Torres-Ruiz J, Wiesik-Szewczyk E, Nowakowska-Plaza A, Sfriso P, Bindoli S, Rizzo S, Hernández-Rodríguez J, Gómez-Caverzaschi V, Araújo O, Mayrink Giardini HA, González-García A, Lopalco G, Viapiana O, Bixio R, Tufan A, Hissaria P, Beecher M, Callisto A, De Paulis A, Dagna L, Campochiaro C, Tomelleri A, Bugatti S, Milanesi A, Ruiz-Irastorza G, Soto-Peleteiro A, Piga M, Cauli A, Conti F, Cardamone C, Triggianese P, Gurnari C, Vitetta R, Prete M, Racanelli V, Talarico R, Ferro F, di Cianni F, Cuccaro MC, Mayo-Juanatey A, Renieri A, Sorrentino V, Ergun MA, Balistreri A, Frediani B, Bocchia M, Fabiani C, Cantarini L, Vitale A.   +56 more
europepmc   +1 more source

Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome. [PDF]

Leukemia
Clough CA, Cunningham C, Philbrook SY, Hueneman KM, Sampson AM, Choi K, Greis KD, Starczynowski D.   +7 more
europepmc   +1 more source

Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism-related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel. [PDF]

Alzheimers Dement
Chen Y, Stevenson TK, Cao Y, Fish LA, Robbins JE, Merrihew GE, Park J, Hohman TJ, MacCoss MJ, Kaczorowski CC.   +9 more
europepmc   +1 more source

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

, 2020
Beck, D, Ferrada, MA, Sikora, KA, Ombrello, AK, Collins, JC, Pei, W, Balanda, N, Ross, DL, Cardona, DO, Wu, Z, Patel, B, Manthiram, K, Groarke, EM, Gutierrez-Rodrigues, F, Hoffmann, P, Rosenzweig, S, Nakabo, S, Dillon, LW, Hourigan, CS, Tsai, WL, Gupta, S, Carmona-Rivera, C, Asmar, AJ, Xu, L, Oda, H, Goodspeed, W, Barron, KS, Nehrebecky, M, Jones, A, Laird, RS, Deuitch, N, Rowczenio, D, Rominger, E, Wells, KV, Lee, C-CR, Wang, W, Trick, M, Wigerblad, G, Brooks, S, Dell’Orso, S, Deng, Z, Chae, JJ, Dulau-Florea, A, Malicdan, MCV, Novacic, D, Colbert, RA, Kaplan, MJ, Gadina, M, Savic, S, Lachmann, HJ, Abu-Asab, M, Solomon, BD, Retterer, K, Gahl, WA, Burgess, SM, Aksentijevich, I, Young, NS, Calvo, KR, Werner, A, Kastner, DL, Grayson, PC   +60 more
openaire   +1 more source

PAXIS: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Phase 2 Study (Part 1) Followed by an Open-Label Period (Part 2) to Assess the Efficacy and Safety of Pacritinib in Patients with VEXAS Syndrome. [PDF]

J Clin Med
Beck DB, Heiblig M, Savic S, Ferrada MA, Mekinian A, Chowdhury O, Hammond D, Weeks LD, Gurnari C, Kirino Y, Georgin-Lavialle S, Buckley SA, Garcha R, Harder BG, Koster MJ.   +14 more
europepmc   +1 more source

Unravelling the Puzzle: Highlighting a Case of VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Mimicker Presented With Inflammatory Symptoms and Pancytopenia. [PDF]

Cureus
Singh A, Yadav A, Singh A.
europepmc   +1 more source