Results 81 to 90 of about 6,714 (194)

Schnitzler Syndrome as an Autoinflammatory Disease Driven by B‐Cell‐Specific Somatic MYD88 Mutation

Allergy, EarlyView.
Yuyi Zhou, Yoko Ueki, Naoya Iwata, Hiroshi Oue, Kentaro Kato, Mengyan Li, Kazushi Izawa, Tomoyasu Jo, Seishi Ogawa, Kenji Kabashima, Naotomo Kambe   +10 more
wiley   +1 more source

VEXAS syndrome : literature review.

Batna Journal of Medical Sciences
VEXAS is an acronym standing for vacuoles, enzyme E1, X-linked, autoinflammatory, and somatic. It designates an autoinflammatory syndrome in adults, first described in 2020, linked to acquired somatic mutations in the UBA1 gene (ubiquitin-activating ...
Abdelhak ABABSA MOUAKI, Ouassila ABBASI
doaj   +1 more source

A new minisatellite-based scheme for the global surveillance of Xanthomonas citri pv. citri, the causal agent of Asiatic Citrus Canker. : S12O12 [PDF]

, 2012
Xanthomonas citri pv. citri (Xcc), the causal agent of Asiatic Citrus Canker, is an internationally major bacterial pathogen currently not reported from countries in the Mediterranean basin, including the EU. Some pathological diversity among strains was
Escalon, Aline, Gagnevin, Lionel, Gordon, Jonathan, Guérin, Fabien, Leduc, Alice, Magne, Maxime, Pruvost, Olivier, Vernière, Christian, Vital, Karine   +8 more
core  

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma:the identification of mechanisms of differential sensitivity [PDF]

, 2018
This study was supported by DEBRA International and funded by DEBRA Austria (Saville-Proby 1). I.M.L and M.K.S were supported by an ERC Advanced Investigator Award (250170, Principal Investigator I.M.L.). C.M.P. and I.M.L.
Anand Subramony, Beheshti Zavareh, Berg, Bright, Chen, Chipuk, Ciechanover, Colomer, DeConti, Duval-Modeste, Fennell, Forslund, Fraga, Garcia, Garcia, Gillingwater, Goldberg, Groettrup, Groettrup, Harousseau, Harper, Harper, Harper, Huang, Ishii, Itin, Jariel-Encontre, Kaufman, Kisselev, Kisselev, Kiyokawa, Kopito, Leigh, Leigh, Leonardi-Bee, Lima, Mager, Magnani, Mao, Maubec, Mayor, McBride, McConkey, Mein, Milhollen, Murrell, Neckers, Nicholson, Nickoloff, Overkleeft, Patil, Proby, Pujol, Rape, Reis, Richardson, Saville, Schindelin, Schmults, Schneider, Schwartz, Schwartz, Soengas, Soengas, South, Suchindran, Sun, Sun, Vij, Wang, Wojcikiewicz, Xiao, Xu, Yewdell, Zonder   +74 more
core   +3 more sources

Distinct Pattern of Atypical Megakaryocytes in VEXAS Syndrome

International Journal of Laboratory Hematology, EarlyView.
Andrew Y. Sung, Jackson W. Douglas, Olga K. Weinberg, Sharon K. Germans, Weina Chen   +4 more
wiley   +1 more source

Comparative Efficacy and Safety of Anakinra and Canakinumab in Patients With VEXAS Syndrome: An International Multicenter Study

Arthritis &Rheumatology, Volume 78, Issue 2, Page 475-482, February 2026.
Objective The aim of this study was to compare differences in clinical response, drug survival, and adverse event rates between anakinra and canakinumab in VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) syndrome. Methods This multicenter international study includes patients with VEXAS from France, Israel, and Italy treated with ...
Tali Eviatar, Dafne Capelusnik, Corrado Campochiaro, Valentin Lacombe, Vincent Jachiet, Michael Zisapel, Iftach Sagy, Oshrat E. Tayer‐Shifman, David Ozeri, Shaye Kivity, Alessandro Tomelleri, Benjamin Terrier, Hagit Peleg, Thibault Comont, Karim Sacre, Pascal Woaye‐Hune, Laurent Arnaud, Estibaliz Lazaro, Vincent Grobost, Francois Lifermann, Maxime Samson, Samuel Ardois, Alice Garnier, Alexandre Maria, Alain Cantagrel, Aurore Meyer, Jean‐David Bouaziz, Mael Heiblig, Lorenzo Dagna, Elisa Diral, Olivier Kosmider, Ori Elkayam, Jérôme Hadjadj, Sophie Georgin‐Lavialle, Olivier Fain, Arsene Mekinian   +35 more
wiley   +1 more source

Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation [PDF]

, 2014
Phosphorylation by the cyclin-dependent kinase 1 (Cdk1) adjacent to nuclear localization signals (NLSs) is an important mechanism of regulation of nucleocytoplasmic transport. However, no systematic survey has yet been performed in human cells to analyze
Bodaen, Mikael, Borsos, Mate, Bozooky, Zoltan, Buday, Laszlo, Christie, Mary, Ellis, Jonathan J., Kobe, Bostjan, Koornyei, Zsuzsanna, Madaraasz, Emilia, Mehdi, Ahmed M., Neubrandt, Mate, Roona, Gergely, Tooth, Judit, Veertessy, Beata G.   +13 more
core   +2 more sources

The ubiquitin system and jasmonate signaling [PDF]

, 2016
The ubiquitin (Ub) system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for ...
Goossens, Alain, Nagels Durand, Astrid, Pauwels, Laurens   +2 more
core   +3 more sources

Successful Treatment of Refractory Sweet's Syndrome With Adalimumab in a Myelodysplastic Syndrome Patient

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT We report a 69‐year‐old man diagnosed as myelodysplastic syndrome and administrated with azacitidine and selinexor treatment. Then he was revealed high fever and multiple tender erythematous papules involving his mouth, back, upper and lower extremities, which were diagnosed as Sweet's syndrome by skin biopsy.
Liya Ma, Yaojia Shen, Jie Chang, Shanshan Suo, Lu Wang, Weifang Zhu, Jianjun Qiao, Hongyan Tong   +7 more
wiley   +1 more source

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]

, 2019
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide, Bard, Bard, Bard, Bashore, Beckwith, Dambacher, de la Peña, Ding, Dong, Eisele, Elsasser, Finley, Glickman, Glickman, Goldstein, Groll, Hershko, Kachroo, Lander, Lasker, Longtine, Matyskiela, Myers, Nemec, Peth, Prakash, Rubin, Smith, Sone, Tomko, Unverdorben, Verma, VerPlank, VerPlank, Wehmer, Wendler, Wenzel, Worden, Worden, Yao, Zhu, Śledź   +42 more
core   +1 more source