Results 41 to 50 of about 4,126 (198)

Dengue Virus Genome Uncoating Requires Ubiquitination [PDF]

, 2016
The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Byk, Laura Andrea, de Maio, Federico Andres, Gamarnik, Andrea Vanesa, Gebhard, Leopoldo German, Iglesias, Nestor Gabriel, Rossi, Mario   +5 more
core   +13 more sources

Characterization of ubiquitin-activating enzyme Uba1 in the nucleus by its mammalian temperature-sensitive mutant. [PDF]

PLoS ONE, 2014
Temperature-sensitive (ts) CHO-K1 mutant tsTM3 exhibits chromosomal instability and cell-cycle arrest in the S to G2 phases with decreased DNA synthesis at the nonpermissive temperature, 39°C.
Kimihiko Sugaya, Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue, Hideo Tsuji   +4 more
doaj   +1 more source

VEXAS syndrome with cutaneous nodules

Dermatology Reports, 2021
Recently, a rare severe autoinflammatory Vacuoles, E1 enzyme, X-linked, autoinflammatory, Somatic (VEXAS) syndrome caused by somatic variants in the UBA1 gene was discovered.
Yahya Argobi
doaj   +1 more source

VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder

Experimental Hematology & Oncology, 2021
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly-described adult-onset inflammatory syndrome characterized by vacuoles in myeloid and erythroid precursor cells and somatic mutations affecting methionine-41 (p.Met41) in
Huijun Huang, Wenjun Zhang, Wenyu Cai, Jinqin Liu, Huijun Wang, Tiejun Qin, Zefeng Xu, Bing Li, Shiqiang Qu, Lijuan Pan, Gang Huang, Robert Peter Gale, Zhijian Xiao   +12 more
doaj   +1 more source

Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells [PDF]

, 2014
The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational NEDD8 conjugation onto target proteins. MLN4924, a selective NAE inhibitor, has displayed preclinical anti-tumor activity in vitro and in vivo, and promising ...
Aaron D Schimmer, Bruno Medeiros, Carolyn A Goard, G Wei Xu, Julia I Toth, Julie L Lukkarila, Mahadeo A Sukhai, Matthew D Petroski, Neil Maclean, Patrick T Gunning, Rabindra N Bhattacharjee, Rose Hurren, Sara R da Silva, Sirano Dhe-Paganon, Stacey-Lynn Paiva   +14 more
core   +9 more sources

Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome

Experimental Hematology & Oncology, 2022
VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is ...
Valentin Lacombe, Annaelle Beucher, Geoffrey Urbanski, Yannick Le Corre, Laurane Cottin, Anne Croué, Anne Bouvier   +6 more
doaj   +1 more source

VEXAS syndrome: a new discovered systemic rheumatic disorder

Rheumatology, 2023
VEXAS syndrome is an adult-onset autoinflammatory disease associated with hematologic symptoms. The disease affects primarily males, and leads to death of a significant proportion of the patients.
Eugeniusz Józef Kucharz
doaj   +1 more source

Faculty Opinions recommendation of Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2020
Sheng Chih Jin
openalex   +3 more sources

A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome [PDF]

, 2007
E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1.
Amerik A. Y., Babbitt S. E., Bertolaet B. L., Bertolaet B. L., Biggins S., Chen L., Cheng I. H., Ciechanover A., Deshaies R. J., Deveraux Q., Elsasser S., Elsasser S., Elsasser S., Finley D., Funakoshi M., Gandre S., Glickman M. H., Guthrie C., Haas A. L., Haracska L., Hicke L., Hofmann K., Johnson E. S., Kang Y., Kleijnen M. F., Kulka R. G., Lambertson D., Lambertson D., Lowe E. D., Madura K., McGrath J. P., Nazli Ghaboosi, Ortolan T. G., Peng J., Pickart C. M., Raasi S., Raasi S., Rao H., Raymond J. Deshaies, Richly H., Ryu K. S., Saeki Y., Saeki Y., Saeki Y., Salvat C., Schauber C., Schuberth C., Shimada K., Swanson R., Swanson R., van Nocker S., van Nocker S., Verma R., Verma R., Verma R., Walters K. J., Walters K. J., Watkins J. F., Wilkinson C.R.M., William Tansey   +59 more
core   +2 more sources

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy [PDF]

, 2016
Acknowledgments Blood biochemistry analysis and serum analysis were performed by the Easter Bush Pathology Department, University of Edinburgh. Animal husbandry was performed by Centre for Integrative Physiology bio-research restructure technical staff ...
Azzouz, Mimoun, Becker, Catherina G., Boyd, Penelope, Come, Julian, Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Karyka, Evangelina, Martinat, Cecile, Parson, Simon H., Powis, Rachael A., Szunyogova, Eva, Thomson, Derek, Wishart, Thomas M., Zheng, Yinan   +15 more
core   +3 more sources