Results 61 to 70 of about 2,299 (157)
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill +4 more
wiley +1 more source
A Novel Use of Anifrolumab for a Novel Disease
ACR Open Rheumatology, Volume 8, Issue 5, May 2026.Objective To explore the potential role of type‐I interferon (IFN‐I) signaling in autoimmune cytopenias outside the context of systemic lupus erythematosus (SLE), and to evaluate the clinical response to off‐label anifrolumab in two patients with fatigue and immune‐mediated cytopenias who did not meet established criteria for SLE.
Zachary Holtz, Adam Schulz, Alexa Meara
wiley +1 more source
The Challenging and Unique Diagnosis of VEXAS Syndrome: A Case Report
Journal of Investigative Medicine High Impact Case ReportsVEXAS syndrome, a myeloid-driven autoinflammatory disorder associated with somatic mutations in the UBA1 gene, was first described in 2020 and presents significant diagnostic challenges due to its complex clinical features, including hematological ...
Jowan Al-Nusair +6 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo +33 more
wiley +1 more source
Rare primary vasculitis: update on multiple complex diseases and the new kids on the block
Advances in RheumatologySystemic vasculitis is a group of rare diseases that share an essential characteristic: inflammation of blood vessel walls. This injury occurs during the disease course, but specific features vary for each entity.
Joao Gabriel Dantas +3 more
doaj +1 more source
Research Progress in VEXAS Syndrome
罕见病研究VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an adult-onset, X-linked clonal autoinflammatory disease caused by somatic mutations in the UBA1 gene, characterized by systemic inflammation accompanied by hematologic clonal ...
JIN Xianghong +4 more
doaj +1 more source
Schnitzler Syndrome as an Autoinflammatory Disease Driven by B‐Cell‐Specific Somatic MYD88 Mutation
Allergy, Volume 81, Issue 8, Page 2969-2971, August 2026.
Yuyi Zhou +10 more
wiley +1 more source
Incidence, Clinical Associations, and Co-Mutation Patterns of UBA1 Mutations in MDS
Blood, 2022 Maria Sirenko +52 more
openaire +2 more sources
Distinct Pattern of Atypical Megakaryocytes in VEXAS Syndrome
International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 713-714, August 2026.
Andrew Y. Sung +4 more
wiley +1 more source