Results 61 to 70 of about 2,418 (172)

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis [PDF]

Somatic mutations in UBA1 cause VEXAS (Vacuoles, E1 ubiquitin activating enzyme, X-linked, Autoinflammatory Somatic) syndrome, an adult-onset inflammatory disease with an overlap of hematologic manifestations.
Cargo C, Collins JC, Grayson PC, Ombrello AK, Alessi H, Tattersall RS, Wilson L, Savic S, Kumar DBU, Poulter JA, Krause K, Werner A, Duncan CJA, Warrington KJ, Kastner DL, Ferrada MA, Calvo KR, Cowen EW, Beck DB, Young NS, Bonnekoh H, Goodspeed W, Kermani TA, Payne EM, Patel BA, Gutierrez-Rodrigues F, Hoffmann P, Koster MJ, Topilow JS, Paik JJ, Cantor A   +30 more
core   +1 more source

VEXAS syndrome in a female with constitutional monosomy X

EULAR Rheumatology Open
: The VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an autoinflammatory disorder that is caused by an acquired deficiency of the UBA1 gene in haematopoietic progenitor cells and predominantly affects elderly males. However,
Nikolas Ruffer, Simon Melderis, Olaf Determann, Lana Harder, Isabell Haase, Ina Kötter, Anja Lüdemann, Martin Krusche   +7 more
doaj   +1 more source

Vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic syndrome in the intensive care unit: a case report

Journal of Medical Case Reports, 2023
Background Vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic syndrome is a newly discovered inflammatory disease affecting male subjects, for which few data exist in the literature.
Félicie Belicard, Nicolas Belhomme, Simon Bouzy, Clémence Saillard, Fabienne Nedelec, Jean-Baptiste Mear, Samuel Ardois, Cedric Pastoret, Florian Reizine, Christophe Camus, Benoit Painvin   +10 more
doaj   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome

Nature Communications
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is caused by inactivating somatic mutations in the UBA1 gene. Here, we characterize the immunological landscape of VEXAS syndrome by performing multi-omics single-cell RNA analysis,
Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Fernanda Gutierrez-Rodrigues, Massimiliano Bissa, Xingmin Feng, Emma M. Groarke, Haoran Li, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden, Sachiko Kajigaya, Peter C. Grayson, Genoveffa Franchini, Neal S. Young, Bhavisha A. Patel   +15 more
doaj   +1 more source

Post‐Translational Control of TaFT1 by WAPO1 Ubiquitination Shapes Spike Architecture and Yield in Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The florigen protein TaFT1 coordinately regulates heading time and spikelet number per spike (SNS), serving as a key yield determinant in wheat. However, how its stability is post‐translationally controlled in the shoot apical meristem remains unclear.
Yujie Jiang, Xiongtao Li, Yiqing Wang, Haoran Wang, Zhaoyan Chen, Chaoqun Dong, Xiangqing Liu, Xincheng Wang, Sufang Li, Weilong Guo, Yingyin Yao, Mingming Xin, Xingguo Ye, Zhongfu Ni, Qixin Sun, Jie Liu   +15 more
wiley   +1 more source

Ras mutation dominantly rescues the reduced lifespan resulting from heterozygous or homozygous mutation in E1.

, 2013
(A, C) Graphs showing the percentage of (A) male and (C) female flies surviving versus time in days for wild-type (+/+) control flies (open circles), for flies carrying one mutant copy of E1 (Uba1B1/+, open squares), and for flies carrying one mutant ...
Hsiu-Yu Liu (286342), Cathie M. Pfleger (286345)   +1 more
core   +1 more source

Ischemia‐Induced Post‐Translational Modifications of GLT‐1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill, Katelyn Louise Reeb, Max Kroll, Ole V. Mortensen, Andréia C. K. Fontana   +4 more
wiley   +1 more source

A Novel Use of Anifrolumab for a Novel Disease

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective To explore the potential role of type‐I interferon (IFN‐I) signaling in autoimmune cytopenias outside the context of systemic lupus erythematosus (SLE), and to evaluate the clinical response to off‐label anifrolumab in two patients with fatigue and immune‐mediated cytopenias who did not meet established criteria for SLE.
Zachary Holtz, Adam Schulz, Alexa Meara
wiley   +1 more source