Results 261 to 270 of about 3,429,300 (308)

PDLIM2 acts as a central regulator of ubiquitination, immune signaling, and mitochondrial metabolism in lung cancer suppression (Review). [PDF]

Int J Oncol
Chuang TH, Guo JH, Yang JX, Tseng JC, Wang HJ, Lai CY.   +5 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Comparative analysis of Cdc48-dependent proteolysis at the ER, mitochondria and chloroplasts. [PDF]

Nat Commun
Lau AS, Nellaepalli S, Jarvis RP.
europepmc   +1 more source

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +1 more source

SCF^JFK regulates osteoblast differentiation through targeting RUNX2. [PDF]

Signal Transduct Target Ther
Shang Z, Zhang Y, Liu Y, Yuan X, Wang J, Fan D, Zou D, Tie D, Pei F, Zhao H, Zheng S, Tang X, Li W, He L.   +13 more
europepmc   +1 more source

The Nuclear Interactome of ATR7 Implicates a Chromatin-Based Repression Mechanism Controlling Oxidative Stress Tolerance and Programmed Cell Death in Arabidopsis. [PDF]

Int J Mol Sci
Qureshi MK, Gechev T.
europepmc   +1 more source

Ubiquitin-elongating enzyme Ufd2 confers resistance to hygromycin B in <i>Saccharomyces cerevisiae</i>. [PDF]

MicroPubl Biol
Paxton KM, Avaala JA, Creviston CS, Gumina J, True JD, Rubenstein EM.   +5 more
europepmc   +1 more source

Photocross-linking activity-based probes to capture the dynamics of ubiquitin RING E3 ligase interactions. [PDF]

Biochem J
Chandler SF, Tatham MH, Branigan E, Nakasone MA, Makukhin N, Ciulli A, Hay RT.   +6 more
europepmc   +1 more source

Ubiquitination-dependent regulation of ferroptosis in ischemic heart and brain. [PDF]

Redox Biol
Zhang YY, Long XY, Tian J, Luo XJ, Peng J.   +4 more
europepmc   +1 more source