Results 261 to 270 of about 81,380 (309)

Identification of Fish Interferon-Stimulated Genes and Their Antiviral Mechanisms. [PDF]

Viruses
Yang E.
europepmc   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

Cis or trans: a puzzle of Parkin activation mechanism. [PDF]

Essays Biochem
Sherawat M, Kumar A, Lenka DR, Kumar A.
europepmc   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

TRIM9 and TRIM26 Interact with UBQLN2^P497H to Modulate Its Proteasomal Degradation. [PDF]

ACS Chem Biol
Chen X, Cao Z, Liang X, Zhao T, Wang Y.
europepmc   +1 more source

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Phytotherapy Research, EarlyView.
Doxorubicin induces cardiac and skeletal muscle atrophy by upregulating E3 ubiquitin ligases, inhibiting myogenic regulatory factors, and activating necroptosis. Cardiac atrophy can further exacerbate cardiotoxicity. 6‐Shogaol negatively regulates these processes and attenuates doxorubicin‐induced cardiac and skeletal muscle atrophy.
Xipeng Sun, Yaxian Wang, Quanjun Yang, Bo Xin, Jinlu Huang, Cheng Guo   +5 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Targeting ubiquitination in disease and therapy. [PDF]

Signal Transduct Target Ther
Yang X, Lan T, Zhang B, Tao X, Qi W, Xie K, Cai Y, Liu C, Han J, Wu H.   +9 more
europepmc   +1 more source

The Role of Ubiquitination and Deubiquitination in the Pathogenesis of Acute Kidney Injury: Progress in Research. [PDF]

Biomedicines
Zhou Y, Tao S, Liu L, Zhang L.
europepmc   +1 more source

Advances in protein ubiquitination modification and immune evasion of breast cancer. [PDF]

Front Cell Dev Biol
Wu Y, Jin J, Cheng X, Fu Z, Xie H.
europepmc   +1 more source