Results 61 to 70 of about 129,362 (255)
Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4. [PDF]
mBioPrevious studies have shown that E6 interacts with the E6-associated protein (E6AP) ubiquitin-protein ligase and directs its ubiquitylation activity toward several specific cellular proteins, one of the most important of which is p53. Interestingly, E6AP
Vats A +7 more
europepmc +2 more sources
The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming [PDF]
Cell Death & Disease, 2020 AbstractDirect reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires a resetting of the epigenome in order to facilitate a cell fate transition. Previous studies have shown that epigenetic modifying enzymes play a central role in controlling induced pluripotency and the generation of iPSC.
Wanhua Xie +3 more
openaire +4 more sources
70 MW-level picosecond mid-infrared radiation generation by difference frequency generation in AgGaS2, BaGa4Se7, LiGaSe2, and LiGaS2 [PDF]
IEEE Photonics Journal ( Volume: 17, Issue: 2, April 2025)Comparative study of nonlinear crystals for picosecond difference frequency generation in mid-IR is presented. Nonlinear crystals of AgGaS$_2$, BaGa$_4$Se$_7$, LiGaSe$_2$, and LiGaS$_2$ were studied. Samples of AgGaS$_2$, BaGa$_4$Se$_7$, LiGaSe$_2$, and LiGaS$_2$ were tested in thee sets having lengths of 2, 4, or 8 mm.
arxiv +1 more source
Reinforcement Learning-Driven Linker Design via Fast Attention-based Point Cloud Alignment [PDF]
arXiv, 2023 Proteolysis-Targeting Chimeras (PROTACs) represent a novel class of small molecules which are designed to act as a bridge between an E3 ligase and a disease-relevant protein, thereby promoting its subsequent degradation. PROTACs are composed of two protein binding "active" domains, linked by a "linker" domain.
arxiv
eLife, 2020 Legionella pneumophila extensively modulates the host ubiquitin network to create the Legionella-containing vacuole (LCV) for its replication. Many of its virulence factors function as ubiquitin ligases or deubiquitinases (DUBs).
Shuxin Liu +5 more
doaj +1 more source
Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. [PDF]
PLoS ONE, 2018 We identified 37 ubiquitin ligases containing RING-finger and transmembrane domains. Of these, we found that RNF183 is abundantly expressed in the kidney. RNF183 predominantly localizes to the endoplasmic reticulum (ER), Golgi, and lysosome.
Yan Wu +9 more
doaj +1 more source
Biomolecules, 2021 Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteasome ...
Rebeca Ibarra +4 more
doaj +1 more source
Poly(dA:dT)-rich DNAs are highly flexible in the context of DNA looping [PDF]
PLOS ONE 8(10): e75799, 2013 Large-scale DNA deformation is ubiquitous in transcriptional regulation in prokaryotes and eukaryotes alike. Though much is known about how transcription factors and constellations of binding sites dictate where and how gene regulation will occur, less is known about the role played by the intervening DNA. In this work we explore the effect of sequence
arxiv +1 more source
Computational and Structural Biotechnology Journal, 2022 Protein ubiquitination plays a vital role in controlling the degradation of intracellular proteins and in regulating cell signaling pathways. Functionally, E3 ubiquitin ligases control the transfer of ubiquitin to the target substrates. As a major family
Xiaohua Lou +7 more
doaj
Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase* [PDF]
Journal of Biological Chemistry, 2010 The related RING domain proteins MdmX and Mdm2 are best known for their role as negative regulators of the tumor suppressor p53. However, although Mdm2 functions as a ubiquitin ligase for p53, MdmX does not have appreciable ubiquitin ligase activity.
Iyappan, Saravanakumar +6 more
openaire +4 more sources