Results 101 to 110 of about 223,344 (207)

The E3 ubiquitin ligase c-IAP1 regulates PCSK9-mediated LDLR degradation: Linking the TNF-α pathway to cholesterol uptake [PDF]

, 2010
Proprotein convertase subtilisin/kexin type 9 (PCSK9), in addition to LDLR (low-density lipoprotein receptor) and APOB (apolipoprotein B), is one of three loci implicated in autosomal dominant hypercholesterolaemia (ADH)^1^.
Lizhi Liu, Weiming Xu
core  

Targeting E3 Ubiquitin Ligases for Cancer Therapy

Cancer Biology & Therapy, 2003
E3 ubiquitin ligases are a large family of proteins that can be classified into three major structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C-Terminus) domain, and E3s with the RING (Really Interesting New Gene) finger, including its derivatives, the U- Box and the PHD (Plant Homeo-Domain).
openaire   +2 more sources

TRIM proteins and CXS chemokines : evolutionary dynamics and functional characterization of two large protein families in teleost fish [PDF]

, 2012
Two large protein families with roles in the immune system were the subject of this thesis. In part one of the thesis, TRIM proteins were studied, which are part of an ancient intracellular immune system. In mammals, TRIM proteins were recently found to
van der Aa, L.M., Aa, L.M., van der
core  

Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells

Molecules
MDM2 and MDM4 are major negative regulators of tumor suppressor p53. Beyond regulating p53, MDM2 possesses p53-independent activity in promoting cell cycle progression and tumorigenesis via its RING domain ubiquitin E3 ligase activity. MDM2 and MDM4 form
Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang   +7 more
doaj   +1 more source

Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase. [PDF]

Cell Chem Biol, 2023
Kim Y, Seo P, Jeon E, You I, Hwang K, Kim N, Tse J, Bae J, Choi HS, Hinshaw SM, Gray NS, Sim T.   +11 more
europepmc   +1 more source

An E3 ubiquitin-proteasome gene signature for predicting prognosis in patients with pancreatic cancer

Frontiers in Immunology
Pancreatic cancer is the seventh leading cause of cancer death worldwide, which is demonstrated with remarkable resistance to radiotherapy and chemotherapy.
Taoyuan Yin, Jingjing Wen, Simiao Xu, Lin Chen, Zhenxiong Zhang, Shutao Pan, Min Zhou, Xingjun Guo, Min Wang, Jun Gong, Hang Zhang, Renyi Qin   +11 more
doaj   +1 more source

Ubiquitination of Sec22b by a novel <i>Legionella pneumophila</i> ubiquitin E3 ligase. [PDF]

mBio, 2023
Ma K, Shu R, Liu H, Fu J, Luo Z-Q, Qiu J.   +5 more
europepmc   +1 more source

Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease. [PDF]

J Virol, 2023
Zang L, Yang X, Chen Y, Huang F, Yuan Y, Chen X, Zuo Y, Miao Y, Gu J, Guo H, Xia W, Peng Y, Tang M, Huang Z, Wang Y, Ma J, Jiang J, Zhou W, Zheng H, Shi W.   +19 more
europepmc   +1 more source

Functional analysis of Arabidopsis thaliana BAH1 in

四川大学学报. 自然科学版, 2017
Protein ubiquitination is one classic type of post-translational modification. The ubiquitin ligase E3 could interact directly with the substrate and mediate in large part the ubiquitination specificity.
LIANG Ke, XU Xi-Bing, NIU Yu-Long, YANG Yi   +3 more
doaj  

Functional Role of RING Ubiquitin E3 Ligase VdBre1 and VdHrd1 in the Pathogenicity and Penetration Structure Formation of Verticillium dahliae. [PDF]

J Fungi (Basel), 2023
Yang X, Hu Z, Yuan J, Zou R, Wang Y, Peng X, Xu S, Xie C.   +7 more
europepmc   +1 more source