Results 111 to 120 of about 223,344 (207)

Native Mass Spectrometry Analysis of Cullin-RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation. [PDF]

Anal Chem
Sternicki LM, Crowe C, Wieske LHE, Ciulli A, Poulsen SA.   +4 more
europepmc   +2 more sources

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS)

Communications Biology
The ubiquitin system regulates virtually all cellular processes, yet the vast majority of ubiquitylation sites identified in the human proteome cannot be attributed to specific E3 ligases.
Tanner M. Tessier, Matthew E. R. Maitland, Maria Kutera, Joseph M. Dybas, Jonathan St-Germain, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Wei Zhang, Brian Raught, Matthew D. Weitzman   +9 more
doaj   +1 more source

The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy. [PDF]

Autophagy Rep, 2023
Berge AKM, Garcia-Garcia J, Sjøttem E, Lauritz Olsvik H.   +3 more
europepmc   +1 more source

Small molecule inhibitors of Mdm2 E3 ubiquitin ligase activity [PDF]

, 2011
Half of cancers retain wild type p53 but have alterations in the pathways involved in p53 regulation. Murine double minute 2 (Mdm2) regulates p53 by acting as an E3 ubiquitin ligase, which tags p53 for degradation through the proteasome. A small molecule
Dickens, Michael
core  

Multiple ubiquitin E3 ligase genes antagonistically regulate chloroplast-associated protein degradation. [PDF]

Curr Biol, 2023
Mohd Ali S, Li N, Soufi Z, Yao J, Johnson E, Ling Q, Jarvis RP.   +6 more
europepmc   +1 more source

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6. [PDF]

Pharmaceutics, 2022
Deshmukh D, Xu J, Yang X, Shimelis H, Fang S, Qiu Y.   +5 more
europepmc   +1 more source

Ubiquitin E3 ligase activity of Ralstonia solanacearum effector RipAW is not essential for induction of plant defense in Nicotiana benthamiana. [PDF]

Front Microbiol, 2023
Ouyang X, Chen J, Sun Z, Wang R, Wu X, Li B, Song C, Liu P, Zhang M.   +8 more
europepmc   +1 more source

Small molecule inhibitors of Mdm2 E3 ubiquitin ligase activity [PDF]

Half of cancers retain wild type p53 but have alterations in the pathways involved in p53 regulation. Murine double minute 2 (Mdm2) regulates p53 by acting as an E3 ubiquitin ligase, which tags p53 for degradation through the proteasome. A small molecule
Dickens, Michael
core   +2 more sources

Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. [PDF]

Brain, 2023
Cutrupi AN, Narayanan RK, Perez-Siles G, Grosz BR, Lai K, Boyling A, Ellis M, Lin RCY, Neumann B, Mao D, Uesugi M, Nicholson GA, Vucic S, Saporta MA, Kennerson ML.   +14 more
europepmc   +1 more source

The Ubiquitin E3 Ligase PRU2 Modulates Phosphate Uptake in Arabidopsis. [PDF]

Int J Mol Sci, 2022
Sun MM, Tian Y, Chun M, Chen YF.
europepmc   +1 more source