Results 151 to 160 of about 231,680 (303)

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy. [PDF]

Autophagy Rep, 2023
Berge AKM, Garcia-Garcia J, Sjøttem E, Lauritz Olsvik H.   +3 more
europepmc   +1 more source

Data from Figure 2: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner

, 2018
Data from Figure 2: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific ...
Paul A. Roche (322739), Adam Szajman (5892278), Ishido, Satoshi, Michael Whalen (3522905), Szajman, Adam, Truong, Sarah Mai, Joanna Bandola-Simon (5892275), Yann C. Klimentidis (147995), Wertheim, Betsy C., Whalen, Michael, Benjamin J. Renquist (5892284), Klimentidis, Yann C., Renquist, Benjamin J., Bhagwandin, Candida, Lonnie Lybarger (5892287), Ashbeck, Erin L., Bandola-Simon, Joanna, Candida Bhagwandin (5892269), Erin L. Ashbeck (5892272), Sarah Mai Truong (5892281), Lybarger, Lonnie, Roche, Paul A., Betsy C. Wertheim (5146601), Satoshi Ishido (272554)   +23 more
core   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Functional Role of RING Ubiquitin E3 Ligase VdBre1 and VdHrd1 in the Pathogenicity and Penetration Structure Formation of Verticillium dahliae. [PDF]

J Fungi (Basel), 2023
Yang X, Hu Z, Yuan J, Zou R, Wang Y, Peng X, Xu S, Xie C.   +7 more
europepmc   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Native Mass Spectrometry Analysis of Cullin-RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation. [PDF]

Anal Chem
Sternicki LM, Crowe C, Wieske LHE, Ciulli A, Poulsen SA.   +4 more
europepmc   +2 more sources

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Functional analysis of Arabidopsis thaliana BAH1 in

四川大学学报. 自然科学版, 2017
Protein ubiquitination is one classic type of post-translational modification. The ubiquitin ligase E3 could interact directly with the substrate and mediate in large part the ubiquitination specificity.
LIANG Ke, XU Xi-Bing, NIU Yu-Long, YANG Yi   +3 more
doaj  

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS)

Communications Biology
The ubiquitin system regulates virtually all cellular processes, yet the vast majority of ubiquitylation sites identified in the human proteome cannot be attributed to specific E3 ligases.
Tanner M. Tessier, Matthew E. R. Maitland, Maria Kutera, Joseph M. Dybas, Jonathan St-Germain, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Wei Zhang, Brian Raught, Matthew D. Weitzman   +9 more
doaj   +1 more source