Results 161 to 170 of about 223,344 (207)
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling. [PDF]
Cell Death DifferHe Y +8 more
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E3 ubiquitin ligases ubiquitinate target proteins
Reactome - a curated knowledgebase of biological pathways, 2016 openaire +1 more source
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Essays in Biochemistry, 2005
The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds).
Helen C, Ardley, Philip A, Robinson
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The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds).
Helen C, Ardley, Philip A, Robinson
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RBR E3 ubiquitin ligases in tumorigenesis
Seminars in Cancer Biology, 2020RING-in-between-RING (RBR) E3 ligases are one class of E3 ligases that is characterized by the unique RING-HECT hybrid mechanism to function with E2s to transfer ubiquitin to target proteins for degradation. Emerging evidence has demonstrated that RBR E3 ligases play essential roles in neurodegenerative diseases, infection, inflammation and cancer ...
Peter, Wang +4 more
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The Role of Ubiquitin E3 Ligase in Atherosclerosis
Current Medicinal Chemistry, 2020Atherosclerosis is a chronic inflammatory vascular disease. Atherosclerotic cardiovascular disease is the main cause of death in both developed and developing countries. Many pathophysiological factors, including abnormal cholesterol metabolism, vascular inflammatory response, endothelial dysfunction and vascular smooth muscle cell proliferation and ...
Zhi-Xiang Zhou +8 more
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E3 ubiquitin ligases for MHC molecules
Current Opinion in Immunology, 2009Recently, novel E3 ubiquitin ligases that target MHC molecules for lysosomal degradation have been discovered by several groups. All these E3s are membrane-bound and possess a variant type RING domain, termed the RING-CH or RING variant (RINGv) domain. They belong to a new E3 family designated Modulator of Immune Recognition (MIR), based on the name of
Satoshi, Ishido +3 more
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Structure of the human UBR5 E3 ubiquitin ligase
Structure, 2022ABSTRACT The human UBR5 (also known as EDD) is a single polypeptide chain HECT-type E3 ubiquitin ligase essential for embryonic development in mammals. Although widely expressed, UBR5 is markedly amplified and overexpressed in breast, ovarian, prostate, gastric and pancreatic ...
Feng Wang +7 more
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Autoantigen Ro52 is an E3 ubiquitin ligase
Biochemical and Biophysical Research Communications, 2006Anti-Ro/SSA antibodies are classic autoantibodies commonly found in patients with Sjögren's syndrome, a chronic autoimmune disease characterized by dryness of the eyes and mouth. The autoantibodies recognize a RING-finger protein, Ro52, whose function is still unknown.
Keiji, Wada, Tetsu, Kamitani
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Ubiquitination on Nonlysine Residues by a Viral E3 Ubiquitin Ligase
Science, 2005Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible for substrate specificity and catalyze the formation of an isopeptide bond between a lysine residue of the substrate (or the N terminus of the ...
Ken, Cadwell, Laurent, Coscoy
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RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination
Biochemical and Biophysical Research Communications, 2010Modification of proteins by ubiquitination plays important roles in various cellular processes. During this process, the target specificity is determined by ubiquitin ligases. Here we identify RNF220 (RING finger protein 220) as a novel ubiquitin ligase for Sin3B. As a conserved RING protein, RNF220 can bind E2 and mediate auto-ubiquitination of itself.
Qinghua, Kong +5 more
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